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The article reports on a survey of visual preferences for suburban office buildings. The participants comprised members of the professions involved in the speculative development of these buildings and building users. The survey method used paired comparisons of photographs representing eight different design types for suburban office buildings. The data were processed using a form of conjoint analysis. Differences in the preferences of architects and users were revealed, confirming previous surveys. Analysis of the preferences showed a different weighting of design attributes. Despite these differences, a design type could be identified that would combine the preferences of both architects and users. This finding is generalized in the proposal for an "ordered preference model" to generate designs which reconcile the preferences of both architects and laypersons.

The building stock in Europe accounts for over 40% of the final energy consumption in the European Union. Moreover, the construction sector is one of the largest producers of industrial waste contributing 40-50% of landfill in some EU countries. A common way of creating a forward planning for resource efficiency in construction project is to apply Life Cycle Cost (LCC - cost evaluation) and Life Cycle Assessment (LCA - environmental evaluation) procedures in the decision process. There are, however, difficulties in current LCC and LCA tools and it is challenging to combine data from those two types of tools since there are poor linkages between them. The EU funded 7th framework project CILECCTA sets out to develop a LCCA (Life Cycle Cost and Analysis) that combines life cycle cost with environmental affect and supports the determination of the costing and sustainability of project alternatives.Current LCC software can assist the decision making process in simulating different alternatives for the design, construction, maintenance and demolition of assets - allowing the client, designer and builder to select the most favourable alternative. Through linking LCC and LCA methodologies, the CILECCTA project will go one stage further by enabling an assessment of the impact of the entire project on the environment and by estimating its sustainability. It will also include probabilistic analysis and the recently developed new generation methodology which applies real options principles analysis for construction industry decision making. This paper sets out the strategic that should lead toward establishing a framework for developing a modular LCCA engine integrating asset-related data from price banks and life cycle inventories. ; Godkänd; 2010; 20101214 (andwan)

"By Sir William Fawcett." cf. BMC. ; "His Majesty caused fresh Orders and Regulations to be given to his Officers, especially relating to the Field-Exercise of his Armies; and from a Manuscript Copy in the German Language is the present Translation published, whereby many Articles of the Prussian Service are made public, which have hitherto been kept secret." cf. p. vi. ; Engraved head-piece. ; Mode of access: Internet. ; Military Service Inst.

Earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate Alzheimer's disease (AD), and other centrally acting reversible acetylcholinesterase (AChE) inhibitors can serve as adjunct pretreatments against poisoning by organophosphorus compounds, including the nerve agent soman. The present study was designed to determine whether pretreatment with a clinically relevant oral dose of galantamine HBr mitigates the acute toxicity of 4.0×LD(50) soman (15.08 µg/kg) in Macaca fascicularis posttreated intramuscularly with the conventional antidotes atropine (0.4 mg/kg), 2-pyridine aldoxime methyl chloride (30 mg/kg), and midazolam (0.32 mg/kg). The pharmacokinetic profile and maximal degree of blood AChE inhibition (∼25%–40%) revealed that the oral doses of 1.5 and 3.0 mg/kg galantamine HBr in these nonhuman primates (NHPs) translate to human-equivalent doses that are within the range used for AD treatment. Subsequent experiments demonstrated that 100% of NHPs pretreated with either dose of galantamine, challenged with soman, and posttreated with conventional antidotes survived 24 hours. By contrast, given the same posttreatments, 0% and 40% of the NHPs pretreated, respectively, with vehicle and pyridostigmine bromide (1.2 mg/kg, oral), a peripherally acting reversible AChE inhibitor approved as pretreatment for military personnel at risk of exposure to soman, survived 24 hours after the challenge. In addition, soman caused extensive neurodegeneration in the hippocampi of saline- or pyridostigmine-pretreated NHPs, but not in the hippocampi of galantamine-pretreated animals. To our knowledge, this is the first study to demonstrate the effectiveness of clinically relevant oral doses of galantamine to prevent the acute toxicity of supralethal doses of soman in NHPs. SIGNIFICANCE STATEMENT: This is the first study to demonstrate that a clinically relevant oral dose of galantamine effectively prevents lethality and neuropathology induced by a supralethal dose of the nerve agent soman in Cynomolgus ...