Suchergebnisse

Abstract. This study develops a model for early warning of snow-caused livestock disasters on a county basis and proposes a method of qualitative risk assessment of snow disasters at 500 m resolution for pastoral areas on the Tibetan Plateau (TP). Data used for the model development include remote sensing data, statistical data of weather, livestock, and social economy, and 45 typical snow disaster cases from 2000 to 2010. The principal component analysis (PCA) approach is used to choose 7 crucial factors that contribute over 85% of information for early warning snow disasters on the TP. They are mean annual probability of snow disaster, number of snow-covered days, livestock stocking rate, continual days of mean daily temperature below −10 °C, grassland burial index, rate of snow-covered grassland, and per livestock gross domestic product. The chosen 411 cases from 2008 to 2010 are used to validate the prediction results from the developed early warning model, with an overall accuracy of 85.64% in predicting snow disasters and no disasters. This suggests that the early warning approach developed in the study has operational potential for predicting snow disasters on the TP.

Mitochondrial dysfunction is linked to pathogenesis of Parkinson's disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria interaction networks (MINs). Here we show that MINs formed nonclassical scale-free supernetworks in colonic ganglia both from healthy controls and PD patients; however, altered network topological patterns were observed in PD patients. These patterns were highly correlated with PD clinical scores and a machine-learning approach based on the MIN features alone accurately distinguished between patients and controls with an area-under-curve value of 0.989. The MINs of midbrain dopaminergic neurons (mDANs) derived from several genetic PD patients also displayed specific changes. CRISPR/CAS9-based genome correction of alpha-synuclein point mutations reversed the changes in MINs of mDANs. Our organelle-interaction network analysis opens another critical dimension for a deeper characterization of various complex diseases with mitochondrial dysregulation. ; F.Q.H. was partially supported by Luxembourg National Research Fund (FNR) CORE programme grant (CORE/14/BM/8231540/GeDES), FNR AFR-RIKEN bilateral programme (TregBAR, F.Q.H. and M.O.), and PRIDE programme grants (PRIDE/11012546/NEXTIMMUNE and PRIDE/10907093/CRITICS). The work was also partially supported through intramural funding of LIH and LCSB through Ministry of Higher Education and Research (MESR) of Luxembourg. The cooperation was achieved through the European Cooperation in Science and Technology (eCOST) Action CA15120 OpenMultiMed. Fibroblasts were obtained from the Neuro-Biobank of the University of Tübingen, Germany. This biobank is supported by the local University, the Hertie Institute, and the DZNE. This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 851255). M.Z. acknowledges the Spanish State Research Agency, through the Severo Ochoa and María de Maeztu Program for Centers and Units of Excellence in R&D (MDM-2017-0711).

Combined with measurements made by very-long-baseline interferometry, the observations of fast TeV gamma-ray flares probe the structure and emission mechanism of blazar jets. However, only a handful of such flares have been detected to date, and only within the last few years have these flares been observed from lower-frequency-peaked BL Lac objects and flat-spectrum radio quasars. We report on a fast TeV gamma-ray flare from the blazar BL Lacertae observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS). with a rise time of ∼2.3 hr and a decay time of ∼36 min. The peak flux above 200 GeV is (4.2 ± 0.6) ×10 photon m s measured with a 4-minute-binned light curve, corresponding to ∼180% of the flux that is observed from the Crab Nebula above the same energy threshold. Variability contemporaneous with the TeV gamma-ray flare was observed in GeV gamma-ray, X-ray, and optical flux, as well as in optical and radio polarization. Additionally, a possible moving emission feature with superluminal apparent velocity was identified in Very Long Baseline Array observations at 43 GHz, potentially passing the radio core of the jet around the time of the gamma-ray flare. We discuss the constraints on the size, Lorentz factor, and location of the emitting region of the flare, and the interpretations with several theoretical models that invoke relativistic plasma passing stationary shocks.© 2018. The American Astronomical Society. All rights reserved. ; VERITAS is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation and the Smithsonian Institution, and by NSERC in Canada. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument. The research at Boston University was supported in part by NASA Fermi Guest Investigator Program grant 80NSSC17K 0694. The VLBA is an instrument of the Long Baseline Observatory (LBO). The LBO is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This research has made use of data from the MOJAVE database that is maintained by the MOJAVE team (Lister et al. 2009) and supported by NASA Fermi grant NNX15AU76G. This work made use of the Swinburne University of Technology software correlator (Deller et al. 2011), developed as part of the Australian Major National Research Facilities Programme and operated under licence. Y.Y.K. and A.B.P. are partly supported by the Russian Foundation for Basic Research (project 17-02-00197), the government of the Russian Federation (agreement 05.Y09.21.0018), and the Alexander von Humboldt Foundation. T.S. was funded by the Academy of Finland projects 274477 and 284495. This research has made use of data from the OVRO 40 m monitoring program (Richards et al. 2011) which is supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G and NSF grants AST-0808050 and AST-1109911. The monitoring of BL. Lacertae and other blazars at the Steward Observatory is supported through NASA Fermi Guest Investigator grant NNX15AU81G. I.A. acknowledges support by a Ramon y Cajal grant of the Ministerio de Economia y Competitividad (MINECO) of Spain. Acquisition and reduction of the MAPCAT data was supported in part by MINECO through grants AYA2010-14844, AYA2013-40825-P, and AYA2016-80889-P, and by the Regional Government of Andalucia through grant P09-FQM-4784. The MAPCAT observations were carried out at the German-Spanish Calar Alto Observatory, which is jointly operated by the Max-Planck-Institut fur Astronomie and the Instituto de Astrofisica de Andalucia-CSIC. The St. Petersburg University team acknowledges support from Russian Science Foundation grant 17-12-01029.