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This paper aims to explore the relationship between the concepts of business model and ecosystem, applied to the creation of cultural cards that generate symbolic, cultural, social and economic value. This is a hybrid study - conceptual and empirical - and exploratory, based on literature review and data analysis collected by 602 questionnaires and 27 interviews. Was conducted a mixed methodology, qualitative and quantitative, and an interpretivist paradigm of constructivist nature. Three main conclusions were drawn. The first suggests that a cultural card is only viable if designed and managed as a business model, with all blocks coherent and articulated with each other and executed in synchronization. The second configures a cultural card as a complex network of interdependent actors functioning in an ecosystem logic that enhances economic growth affirmed by creative competitiveness. The third points out a cultural card as a cultural agent, for the symbolic value it promotes dominated by the discourse of 'now' and 'already', inherent in the access-based economy This paper: (1) perspectives that cultural and creative development involves the creation of a valuable macro ecosystem and a robust national network articulated with local and specific micro ecosystems; (2) evidences the importance of creativity and innovation, inherent to the business model, for the production and diffusion of knowledge, fruition and democratization of culture in the face of the diversity of emerging market segments and (3) provides propositions applicable to the universe of cultural and creative industries that are carriers of new insights that can be explored and knowledge increased. The value of this paper lies in the exploration of a new look at the theme of cultural cards embodied in a logic of an ecosystemic business model. ; info:eu-repo/semantics/publishedVersion

Agriculture is widespread across the EU and has caused considerable impacts on freshwater ecosystems. To revert the degradation caused to streams and rivers, research and restoration efforts have been developed to recover ecosystem functions and services, with the European Water Framework Directive (WFD) playing a significant role in strengthening the progress. Analysing recent peer-reviewed European literature (2009–2016), this review explores 1) the conflicts and difficulties faced when restoring agriculturally impacted streams, 2) the aspects relevant to effectively reconcile agricultural land uses and healthy riverine ecosystems and 3) the effects and potential shortcomings of the first WFD management cycle. Our analysis reveals significant progress in restoration efforts, but it also demonstrates an urgent need for a higher number and detail of restoration projects reported in the peer-reviewed literature. The first WFD cycle ended in 2015 without reaching the goal of good ecological status in many European water-bodies. Addressing limitations reported in recent papers, including difficulties in stakeholder integration and importance of small headwater streams, is crucial. Analysing recent developments on stakeholder engagement through structured participatory processes will likely reduce perception discrepancies and increase stakeholder interest during the next WFD planning cycle. Despite an overall dominance of nutrient-related research, studies are spreading across many important topics (e.g. stakeholder management, land use conflicts, climate change effects), which may play an important role in guiding future policy. Our recommendations are important for the second WFD cycle because they 1) help secure the development and dissemination of science-based restoration strategies and 2) provide guidance for future research needs

Digues maritimes et fluviales de protection contre les submersions - 2ème colloque national - Digues2013, Aix-en-Provence, FRA, 12-/06/2013 - 14/06/2013 ; National audience ; La Loire est un fleuve dont les endiguements sont importants aussi bien en hauteur, qu'en longueur et en population protégée. On dénombre une cinquantaine de systèmes d'endiguements sur les bords du fleuve royal, une grande partie construite depuis le moyen âge ayant été décidée par les rois de France, ces digues sont encore aujourd'hui la propriété de l'État Français et sont gérées par les services des préfectures.Les études de dangers des digues de classe A de la Loire ont été remises pour la fin de l'année 2012 aux services de contrôle. Elles sont au nombre de trois : la levée d'Orléans [1], les levées de Tours [2] et la grande levée de l'Authion [3]. À eux trois, ces systèmes d'endiguements représentent plus de 170 kilomètres de digue et protègent quelques 230 000 habitants.Ces études ont permis de mettre à plat les connaissances hydrauliques, géotechniques, morphodynamiques et géographiques (situation des enjeux et populations) relatives aux ouvrages. Elles ont permis de connaître les tronçons de levée les plus fragiles avec leur probabilité de rupture. Ainsi elles donnent une vision objective des risques encourus par les populations concernées derrière ces digues.Elles produisent des analyses qui vont permettre de mettre en place une politique de réduction du risque. Cette politique sera basée sur plusieurs types d'actions :- sur la gestion (gestion de l'ouvrage - gestion du territoire) - sur les ouvrages (structurelles - fonctionnelles) - sur la connaissance (phénomènes - ouvrages et fondations - historique) Les études débouchent donc sur un programme ambitieux à cours, moyen et long terme.

Purpose of the studyEfficacy of DRV‐containing regimen in antiretroviral‐experienced patients in Brazil is unknown. The aim of this study was to evaluate the prevalence and risk factors associated with virologic failure (VF) to DRV containing salvage regimen in experienced HIV‐infected patients in Sao Paulo and also determine the prevalence of DRV resistance associated mutations (RAM) in this population.MethodsRetrospective study of 131 patients who started a DRV‐containing salvage regimen between 12/2007 to 12/2009 in 2 centers in Sao Paulo. Protease resistance mutations listed by 2011 IAS‐USA panel update were considered. Genotypic sensitivity score (GSS) was calculated for the proposed regimen using the 2008 Rega algorithm. We have assessed VF during 48 weeks of follow up and VF was defined as the failure to achieve viral suppression in 48 weeks or viral rebound after suppression. Stopping the use of DRV for any reason was also considered VF.Summary of resultsWe analysed 131 patients, 71% male, median age 44y. More than half of the patients had a baseline CD4 cell count<200/mm3 (58,9%) although only 21,4% presented a VL ≥100.000 copies/ml. 78,6% had previous used more than 2 PI and more than half of the patients harbored viruses with at least 11 IAS PI resistance mutations (59,5%) The majority of patients had less than 2 DRV RAM (84,7%) and the most prevalent major and minor DRV RAM were respectively I84V (24,4%) and L33F (34,3%). Most patients (79,4%) have received more than 2 active drugs in their regimen. Twenty patients (15,3%) have failure in achieving VL <50copies/ml at 48 weeks. Ten patients were lost of follow up and the remaining 10 were treatment failure. In multivariate analysis, VL≥ 100.000 copies/mL (p=0,002), less than 15 years of HIV diagnosis (p=0,013) and previous fosamprenavir use (p=0,027) were independently predictive of VF.ConclusionsThis study, conducted in routine clinical conditions, is probably the large cohort to evaluate risk factors to VF with DRV containing regimen worldwide and is the first one to evaluate prevalence of VF with DRV containing regimen in Brazil. We found an elevated response rate in this population (84,7%) which couples with the low number of DRV RAM despite the elevated number of previous PI used and by the high GSS. The factors associated with VF were similar to previous reports except for the time of HIV diagnosis, and one can speculate that this correlates with lower adherence in this group.

Solar photovoltaic represent one of the most promising technologies for generating electrical energy from renewable sources. In fact, as a result of the technological advances in the field of microelectronics and power electronics, photovoltaic systems have reached historic lows in terms of costs, surpassing the other types of renewable energy sources. The potential of the solar photovoltaic systems is enormous, being capable of meeting the energy needs of today, without compromising future needs, and allowing a sustainable development. With this in mind, several incentives and, consequently, legislations have been implemented around the world. In the Portuguese case, depending on the type of contract, for photovoltaic solar installations with value of power up to 1500 Wp the production surplus is injected into the power grid without any financial compensation. Considering the high investment, particularly regarding the photovoltaic panels, the support structure and the power electronics converters, it could be interesting to implement a system capable of storing the surplus energy for later use by the owner of the photovoltaic installation. This paper presents a study on the viability of energy storage systems in photovoltaic installations up to 1500 Wp. For this study, different consumer profiles, types of installations and geographic locations were considered, in order to perceive the technological and economic viability of this solution. ; This work has been supported by FCT -Fundancao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2019. This work is financed by the ERDF COMPETE 2020 Programme, and FCT within project SAICTPAC/0004/2015-POCI-01-0145-FEDER-016434 and FCT within project PTDC/EEI-EEE/28813/2017. Mr. Luis A. M. Barros is supported by the doctoral scholarship PD/BD/143006/2018 granted by the Portuguese FCT ...

A revisão da literatura aponta que a sexualidade é entendida como algo inerente, sendo constituída ao longo da vida. Sexo é expressão biológica que define um conjunto de características anatômicas e funcionais (genitais e extragenitais). A construção do que é pertencer a um ou outro sexo, se dá pelo tratamento diferenciado para meninos ou meninas, inclusive nas expressões diretamente ligadas à sexualidade e pelos padrões socialmente estabelecidos. Esses padrões são oriundos das representações sociais e culturais construídas a partir das diferenças biológicas dos sexos e transmitidas pela educação, o que atualmente recebe o nome de relações de gênero. O intuito deste trabalho é averiguar o quanto os alunos são influenciados pelos conceitos culturais que estabelecem o que é adequado em relação ao gênero e se agem em conformidade a eles. Trata-se de uma pesquisa quanti-qualitativa, por meio da aplicação de um questionário a alunos do sétimo ao nono anos de escolas públicas da Cidade de Cláudio. Os resultados apontam que esse tema tem que ser mais debatido e aprofundado em todos os segmentos educacionais. E a Educação Física especificamente deve cumprir um dos objetivos gerais da no ensino fundamental, que por meio de sua práxis deve levar os alunos a participar de atividades corporais, estabelecendo relações equilibradas e construtivas com os outros, reconhecendo e respeitando características físicas e de desempenho de si próprio e dos outros, sem discriminar por características pessoais, físicas, sexuais ou sociais.

Objective: Many studies point to the negative impact of discrimination on the psychological and social functioning of ethnic minority persons. The realization of these studies across multiple European countries enables a systematization of this knowledge, which is our goal in the present work. Method: This study presents a systematic review and a meta-analysis of the correlates of perceived ethnic discrimination among ethnic minority persons living in European countries. Results: The analyses of 121 effect sizes reveal that discrimination is positively associated with symptoms of psychiatric disturbances, depression, psychosis, perceived stress, and externalizing behavior. Discrimination is also negatively associated with the self-esteem, positive evaluation of life, self-efficacy/mastery, well-being, and psychological adaptation of migrants. The results show that the strength of these relationships is, in some cases, moderated by persons' gender, age, and ethnicity and countries' multicultural preference and countries' rating in the Migrant Integration Policies Index (MIPEX), namely, in regard to labor market mobility, permanent residence, and antidiscrimination policies. Conclusions: The detrimental effect of discrimination on many psychosocial dimensions emphasizes the need for governmental agencies to develop systemic and concrete interventions to decrease ethnic prejudice in Europe. Moreover, the results show that fostering multiculturalism, and implementing broad antidiscrimination policies has a protective function in the face of discrimination. Enforcing the implementation of these policies can be a fundamental way to promote the psychological adjustment of ethnic minority persons. ; info:eu-repo/semantics/acceptedVersion

AbstractThe COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural–geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

EU ; Fonds zur Forderung der wissenschaftlichen Forschung (FWF) of Austria ; Russian Foundation for Basic Research (RFBR) ; Fundação para a Ciência e a Tecnologia (FCT) ; FCT ; MEC ; FEDER ; DURSI ; European Union ; Spanish MCYT ; Junta de Andaluc a ; CICYT ; APART ; European Community through a Marie Curie Fellowship ; MEC Ramon y Cajal ; Science and Technology Facilities Council (STFC) ; Fermi Research Alliance ; LLC ; Belgian Federal Science Policy ; RFFI ; Bundesministerium für Bildung und Forschung (BMBF) ; EU: MRTN-CT2004-503369 ; EU: MRTN-CT-2006-035505 ; EU: HPRN-CT-2000149 ; EU: HPRN-CT-2000-00152 ; EU: MRTN-CT-2006-035482 ; Fonds zur Forderung der wissenschaftlichen Forschung (FWF) of Austria: P18959-N16 ; RFBR: 07-02-00256 ; Fundação para a Ciência e Tecnologia (FCT): SFRH/BD/13936/2003 ; Fundação para a Ciência e Tecnologia (FCT): SFRH/BD/18762/2004 ; FCT: POCI/FIS/59741/2004 ; FCT: SFRH/BPD/5575/2001 ; FCT: SFRH/BPD/23427/2005 ; FEDER: 2004-04582-C02-01 ; DURSI: 2005SGR00564 ; DURSI: 2001SGR-00188 ; European Union: MEIF-CT2003-500030 ; Spanish MCYT: FPA2003-09298-C02-01 ; Junta de Andaluc a: FQM-101 ; CICYT: FPA2002- 00648 ; LLC: DE-AC0207CH11359 ; Belgian Federal Science Policy: IAP 6/11 ; RFFI: N 07-02-00256 ; German Ministry of Education and Research (BMBF): 05HT6WWA ; This chapter of the "Flavor in the era of LHC" workshop report discusses flavor-related issues in the production and decays of heavy states at the LHC at high momentum transfer Q, both from the experimental and the theoretical perspective. We review top quark physics, and discuss the flavor aspects of several extensions of the standard model, such as supersymmetry, little Higgs models or models with extra dimensions. This includes discovery aspects, as well as the measurement of several properties of these heavy states. We also present publicly available computational tools related to this topic.

The Complete Calibration of the Colour-Redshift Relation survey (C3R2) is a spectroscopic e ffort involving ESO and Keck facilities designed specifically to empirically calibrate the galaxy colour-redshift relation - P(z jC) to the Euclid depth (iAB = 24 :5) and is intimately linked to the success of upcoming Stage IV dark energy missions based on weak lensing cosmology. The aim is to build a spectroscopic calibration sample that is as representative as possible of the galaxies of the Euclid weak lensing sample. In order to minimise the number of spectroscopic observations necessary to fill the gaps in current knowledge of the P(z jC), self-organising map (SOM) representations of the galaxy colour space have been constructed. Here we present the first results of an ESO@VLT Large Programme approved in the context of C3R2, which makes use of the two VLT optical and near-infrared multi-object spectrographs, FORS2 and KMOS. This data release paper focuses on high-quality spectroscopic redshifts of high-redshift galaxies observed with the KMOS spectrograph in the near-infrared H- and K-bands. A total of 424 highly-reliable redshifts are measured in the 1:3 2 galaxies. ; European Space Agency European Commission Academy of Finland European Commission Agenzia Spaziale Italiana (ASI) Belgian Federal Science Policy Office Canadian Euclid Consortium Centre National D'etudes Spatiales Helmholtz Association German Aerospace Centre (DLR) Danish Space Research Institute Fundacao para a Cienca e a Tecnologia Spanish Government National Aeronautics & Space Administration (NASA) Netherlandse Onderzoekschool Voor Astronomie Norvegian Space Center Romanian Space Agency State Secretariat for Education, Research and Innovation (SERI) at the Swiss Space Office (SSO) United Kingdom Space Agency ESO programme 199.A-0732 Helmholtz Association German Aerospace Centre (DLR) 50 QE 1101 Spanish Ministry of Science, Innovation and Universities ESP2017-89838-C3-1-R H2020 programme of the European Commission 776247 Swiss National Science Foundation (SNSF) European Commission PRIN MIUR 2015 "Cosmology and Fundamental Physics: Illuminating the Dark Universe with Euclid"