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International audience ; The performance gap between the design and the as-built energy performance of buildings is considered a significant risk that may compromise the efforts on meeting the carbon reduction targets set by governments in Europe. The relative importance of irregularities or defects within building walls is more prominent when the thermal insulation level increases. It is thus necessary to quantify the global thermal insulation level of building walls (i.e., including thermal bridges). Classical contact measurement methods only allow local measurements and would thus require the use of a high number of sensors which would limit their applicability. Besides, the presence of thermal bridges prevents the use of contact heat flux measurements because of the 2D or 3D nature of the associated heat transfers through the building walls. To overcome these limitations, the present study proposes an alternative approach consisting in measuring the heat flux on one location and extrapolating its value on the whole building wall through the measurement of the total heat transfer coefficient. Therefore, we developed and/or further improved five different in situ measurement methods of the total heat transfer coefficient on building walls. The measurement methods were thoroughly tested indoor thanks to lab-scale experiments carried out both in steady-state and transient regimes. The results obtained demonstrated the accuracy and the robustness of the proposed methods, as well as their intrinsic limitations. These in situ methods can be used to assess the heat losses on a whole building wall, including the contribution of thermal bridges.

International audience ; The performance gap between the design and the as-built energy performance of buildings is considered a significant risk that may compromise the efforts on meeting the carbon reduction targets set by governments in Europe. The relative importance of irregularities or defects within building walls is more prominent when the thermal insulation level increases. It is thus necessary to quantify the global thermal insulation level of building walls (i.e., including thermal bridges). Classical contact measurement methods only allow local measurements and would thus require the use of a high number of sensors which would limit their applicability. Besides, the presence of thermal bridges prevents the use of contact heat flux measurements because of the 2D or 3D nature of the associated heat transfers through the building walls. To overcome these limitations, the present study proposes an alternative approach consisting in measuring the heat flux on one location and extrapolating its value on the whole building wall through the measurement of the total heat transfer coefficient. Therefore, we developed and/or further improved five different in situ measurement methods of the total heat transfer coefficient on building walls. The measurement methods were thoroughly tested indoor thanks to lab-scale experiments carried out both in steady-state and transient regimes. The results obtained demonstrated the accuracy and the robustness of the proposed methods, as well as their intrinsic limitations. These in situ methods can be used to assess the heat losses on a whole building wall, including the contribution of thermal bridges.

If misregulated, macrophage (M)T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-M (GM-CSF)- and M colony-stimulating factor (M-CSF)-dependent Ms have dichotomous effects on T cell activity. While GM-CSF-dependent Ms show a highly stimulatory activity typical for M1 Ms, M-CSF-dependent Ms, marked by folate receptor (FR), adopt an immunosuppressive M2 phenotype. We find the latter to be caused by the purinergic pathway that directs release of extracellular ATP and its conversion to immunosuppressive adenosine by co-expressed CD39 and CD73. Since we observed a misbalance between immunosuppressive and immunostimulatory Ms in human and murine arthritic joints, we devised a new strategy for RA treatment based on targeted delivery of a novel methotrexate (MTX) formulation to the immunosuppressive FR+CD39+CD73+ Ms, which boosts adenosine production and curtails the dominance of proinflammatory Ms. In contrast to untargeted MTX, this approach leads to potent alleviation of inflammation in the murine arthritis model. In conclusion, we define the M extracellular purine metabolism as a novel checkpoint in M cell fate decision-making and an attractive target to control pathological Ms in immune-mediated diseases. ; The research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Program under grant agreement No 683356 - FOLSMART and from the Seventh Framework Program (FP7/2007-2013) under grant agreement NMP4-LA-2009-228827 NANOFOL. RP was supported by the Boehringer Ingelheim Fonds and the Ph.D. program Cell Communication in Health and Disease supported by the Austrian Science Fund (FWF). VL was supported by the FWF (P22908), VEGA (2/0063/14), and APVV (16-0452). JH received support from the Vienna Science and Technology Fund (WWTF) LS14-031. ...