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Using the Atacama Large Millimeter/submillimeter Array, we observed the young Herbig star HD 100546, host to a prominent disk with a deep, wide gap in the dust. The high-resolution 1.3 mm continuum observation reveals fine radial and azimuthal substructures in the form of a complex maze of ridges and trenches sculpting a dust ring. The (CO)-C-12(2-1) channel maps are modulated by wiggles or kinks that deviate from Keplerian kinematics particularly over the continuum ring, where deviations span 90 degrees in azimuth, covering similar to 5 km s(-1). The most pronounced wiggle resembles the imprint of an embedded massive planet of at least 5 M-Jup predicted from previous hydrodynamical simulations. Such a planet is expected to open a deep gap in both gas and dust density fields within a few orbital timescales, yet the kinematic wiggles lie near ridges in the continuum. The lesser strength of the wiggles in the (CO)-C-13 and (CO)-O-18 isotopologues show that the kinematic signature weakens at lower disk heights, and suggests qualitatively that it is due to vertical flows in the disk surface. Within the gap, the velocity field transitions from Keplerian to strongly non-Keplerian via a twist in position angle, suggesting the presence of another perturber and/or an inner warp. We also present Very Large Telescope/SPHERE sparse aperture masking data that recover scattered light emission from the gap's edges but show no evidence for signal within the gap, discarding a stellar binary origin for its opening. ; government of Chile grant Millennium Scientific Initiative RC130007 government of Chile grant CONICYT-Gemini 32130007 government of Chile grant CONICYT-FONDECYT 1171624 1171246 1191934 Government of Chile CONICYT PAI 2017 PAI77170087 European Union (EU) 748544 Joint Committee of ESO

Please read abstract in the article. ; The authors of this Letter thank the following organizations and programs: the Academy of Finland (projects 274477, 284495, 312496); the Advanced European Network of E-infrastructures for Astronomy with the SKA (AENEAS) project, supported by the European Commission Framework Programme Horizon 2020 Research and Innovation action under grant agreement 731016; the Alexander von Humboldt Stiftung; the Black Hole Initiative at Harvard University, through a grant (60477) from the John Templeton Foundation; the China Scholarship Council; Comisión Nacional de Investigación Científica y Tecnológica (CONICYT, Chile, via PIA ACT172033, Fondecyt 1171506, BASAL AFB-170002, ALMA-conicyt 31140007); Consejo Nacional de Ciencia y Tecnología (CONACYT, Mexico, projects 104497, 275201, 279006, 281692); the Delaney Family via the Delaney Family John A. Wheeler Chair at Perimeter Institute; Dirección General de Asuntos del Personal Académico–Universidad Nacional Autónoma de México (DGAPA–UNAM, project IN112417); the European Research Council Synergy Grant "BlackHoleCam: Imaging the Event Horizon of Black Holes" (grant 610058); the Generalitat Valenciana postdoctoral grant APOSTD/2018/177; the Gordon and Betty Moore Foundation (grants GBMF-3561, GBMF-5278); the Istituto Nazionale di Fisica Nucleare (INFN) sezione di Napoli, iniziative specifiche TEONGRAV; the International Max Planck Research School for Astronomy and Astrophysics at the Universities of Bonn and Cologne; the Jansky Fellowship program of the National Radio Astronomy Observatory (NRAO); the Japanese Government (Monbukagakusho: MEXT) Scholarship; the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for JSPS Research Fellowship (JP17J08829); JSPS Overseas Research Fellowships; the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS, grants QYZDJ-SSWSLH057 QYZDJ-SSW-SYS008); the Leverhulme Trust Early Career Research Fellowship; the Max-Planck-Gesellschaft (MPG); the Max Planck Partner Group of the ...