Suchergebnisse

It was studied the effect of a lipid extract isolated from the marine green algae Codium fragile (Suringar) Hariot on the liver and blood biochemical indicators in mice under impact of acute stress (vertical fixation by the dorsal neck fold). The pharmacological effect of the C. fragile lipid extract was manifested in the restoration of lipid and carbohydrate metabolism, as well as in the normalization of the indicators of the endogenous antioxidant defense system under stress effect. The biological activity of the lipid extract of C. fragile, probably, is due to the action of its constituent polyunsaturated fatty acids of the ω-3 and ω-6 families. The lipid extract of C. fragile was not inferior to the reference Omega-3 preparation in restoring the body's metabolic reactions caused by the impact of the stress, however, it showed higher antioxidant activity.

The influence of the lipid complex isolated from the thallus of the red marine algaeAhnfeltia tobuchiensis(LCA) on the metabolic parameters of the blood and liver of rats under a high-fat diet was studied. It was shown that the administration of LCA had a pronounced lipid-correcting and antioxidant effect, which was superior to that of the reference preparation "Omega 3-6-9" in terms of its ability to restore lipid metabolism, the ratio of lipoprotein fractions and the indices of the endogenous antioxidant protection system, as so as prevent the development of hepatosis. The lipid-correcting and anti-oxidant effect of LCA is specified by the action of n-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, which are the part of the structure of phospholipids and glycolipids of marine origin, which make up the main part of the studied lipid complex.