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El presente documento contiene los resultados de un estudio realizado en San Cristóbal de Las Casas, Chiapas, México, con el objetivo de analizar las percepciones de la población respecto al deterioro ambiental y al concepto de desarrollo sustentable. El estudio se basó en el análisis de percepciones como fuente de datos. Los principales hallazgos fueron: 1) la población de estudio detecta cambios ambientales, pero los considera necesarios para el desarrollo, y 2) se define el desarrollo sustentable como "cuidado ambiental" que parte de los programas de gobierno, o bien como una modalidad que permite contar con un empleo para el bienestar familiar. La construcción de conceptos juega un papel importante para medir el impacto de las acciones ecologistas, aunque la conceptualización de "desarrollo sustentable" en la población actualmente no incide en el desarrollo y la valoración de programas ambientales.

Under the conditions of the increasing globalization of markets, changing consumer habits, frequent outbreaks of foodborne illnesses (FBI), social organizations and governments seeking production and food supply include the assurance of safeness in all links in the chain. One way to achieve it, is to implement a Quality Management System (QMS) for certification in agricultural production units, the process addresses the farm give the perspective of general systems theory, shaped by production subsystems and support; them develop both technical and management activities that seek to streamline processes while maintaining standards of sustainability and social responsibility to achieve food production with previously established quality criteria. the process of developing and implementing the QMS requires the construction and operation of support documents and manuals on issues of organization, and organization of producers, which are structured to meet the requirements of a standard, protocol or code of conduct; their compliance is verified through inspections that could lead to the granting of certification or seal of product quality or service, the process can be developed individually by a producer or a producer organization. ; En las condiciones de creciente globalización de los mercados, cambio en los hábitos de consumo, frecuente aparición de brotes de enfermedades transmitidas por alimentos (ETAS), las organizaciones sociales y los gobiernos buscan que la producción y provisión de alimentos incluya el aseguramiento de lainocuidad en todos los eslabones de la cadena. Una de las formas para lograrlo, es la implementación de un Sistema de Gestión de Calidad (SGC) con #nes de certi#cación en las unidades productivas agropecuarias; el proceso aborda la #nca desde la óptica de la teoría general de los sistemas, con#gurada por subsistemas productivos y de soporte; en ellos se desarrollan actividades tanto técnicas como administrativas que buscan optimizar los procesos, manteniendo criterios de sostenibilidad y ...

The aim of this study is to assess the potential effectiveness of GMES Space Component Sentinel Missions for land-based environmental policy support in the Azores Autonomous Region (Portugal). Sixteen different types of legal and spatial instruments are currently being applied in this region. Most of them require detailed and accurate Land-use/Land- cover cartography in order to deliver reliable outputs at municipal, island and archipelagic scales. Sentinel-2 Mission products can fulfill these requirements in a cost-effective way. A Spatial Data Infrastructure-based Regional GMES framework is proposed in order to process, assess, validate and integrate this GMES data into the decision support system of Azorean regional land policies. ; This research has been developed on the behalf of a Doctoral (M3.1.2/F/025/2007) and a Post-Doctoral (M3.1.7/F/005/2011) Research Project, both supported by the Azorean Regional Secretary of Science, Technology and Equipment (Azorean Regional Government). This work was partially funded by Portuguese National Funds through FCT – Fundação para a Ciência e Tecnologia (Foundation for Science and Technology), under the project "PTDC/AAC-AMB/098786/2008". ; Peer Reviewed

Objectives: To estimate, the impact of population ageing on the costs and burden of Heart Failure (HF) in Portugal over a twenty-year horizon, between 2014 and 2034. MethOds: HF costs were estimated using a prevalence-based approach. Costs and disability were assumed zero for patients in class I of the New York Heart Association (NYHA) Functional Classification. The prevalence rate was estimated using microdata from a previous epidemiological survey. Average direct costs per patient were estimated using: 1) a primary care national database with records of 25,337 patients registered with HF; 2) National DRG microdata; 3) expert panel; 4) national literature, reports and legislation. Indirect costs associated to patients' absenteeism and early exit from the labour force were considered. The burden was measured in Disability Adjusted Life Years (DALY) resulting from the sum of Years Lost due to Disability (YLD) and Years of Life Lost (YLL) due to premature death. For YLL, mortality rates reported in the European Detailed Mortality Database were considered. For YLD, disease duration and the overall incidence were estimated using the software DisMod II. Disability weights were retrieved from published literature. Population ageing was carried out by a shift-share analysis using the official demographic projections. Results: Considering only population ageing on a 20-year horizon, HF prevalence (class II-IV) is expected to increase by 25%, reaching over 312,000 patients in 2034. Total costs in 2014 and 2034 are estimated, respectively, at €289M and €364M (at today's prices), with an increase in the costs per inhabitant of 34%. In 2034, total DALY are expected to be 25% higher than in 2014, from 21,162 to 26,521. The contribution of YLL will increase from 54% to 61%. cOnclusiOns: Population ageing will substantially increase the burden of HF in Portugal. Health policy makers should consider new strategies to deal with this problem. ; info:eu-repo/semantics/publishedVersion

In 2009, genotypic drug resistance testing was introduced for HIV‐1 patients failing antiviral therapy in Cuba. The high prevalence of drug resistance in this population indicated the need for surveillance of transmitted drug resistance (TDR) in therapy‐naïve patients. Therefore, the objectives of this study were to analyze the level and patterns of TDR and subtype in therapy‐naïve HIV‐1 patients in Cuba from 2006 to 2011, and to compare it with reported data from 2004 that indicated 4% TDR, solely restricted to NRTI. 153 plasma from HIV‐1 therapy‐naïve patients were collected between June 2006 and December 2011 and subsequently extracted, amplified and sequenced. Drug resistance was interpreted according to HIVdb v.6.1.1 and WHO list for TDR surveillance (2009) using the CPR tool v.6.0. Phylogenetic analysis was performed using Neighbour Joining (Kimura 2) in Mega 4. The majority of patients was male (82.4%), MSM (68.6%) and originated from Havana province (68.1%). 8.4% were recent infections. Subtype B was the most prevalent subtype (31.3%) followed by CRF20‐23‐24_BG (28.1%), CRF19 (18.3%) and CRF18 (13.0%). The prevalence of subtype B declined from 43.7% in the 2004 study to 31.3% in the present study, whereas BG recombinants increased from 14.4% to 28.1%. Overall, 12.4% (19/154) had evidence of TDR. 3.9% carried at least one NRTI, 1.9% at least one NNRTI and 1.9% at least one PI mutation. Drug resistance mutations against both NRTI and NNRTI were observed in 3.9%, whereas triple class resistance was found in only 0.6%. The most frequent NRTI mutations were M184V (55.5%), T215F/Y/rev (16.6%) and K70R (16.6%). The most frequent NNRTI mutations were K103N (61.1%) and G190A (22.2%). The most common PI mutation was L90M (5.5%). From the 19 patients with TDR, 13 (68.4%) were diagnosed with a recent HIV‐1 infection. AZT/D4T + 3TC + NVP may be effective in 6 of the patients with TDR (31.5%), partially effective in 6 (31.5%) and ineffective in 7 (36.8%). AZT/D4T + 3TC + IDV would be effective in 9 of the patients with TDR (47.3%), partially effective in 8 (42.1%) and ineffective in 2 (10.5%). This analysis confirmed the further expansion of BG recombinants in Cuba and revealed that antiretroviral drug resistance in HIV‐1 therapy‐naïve patients has increased to 12.4% in 2006–2011. The current study emphasizes the need to perform surveillance studies for TDR in therapy‐naïve patients, as the extent of TDR might jeopardize the effectiveness of first‐line regimens prescribed in Cuba.

We evaluated genetic and environmental factors affecting age at first farrowing of sows in the Brazilian southeast. For this purpose, 466 observations regarding the age at first farrowing were made for Dalland-C40© animals belonging to two herds. The effects of the environmental factors on this trait were assessed by means of a model that included, as random effects, the influence of the sow's father and mother and, as fixed effects, the influence the year of birth, the herd and the birth season, along with the covariable litter size at birth. The variance components were estimated using the derivative-free restricted maximum likelihood method. The estimated mean was 354.8 ± 25.87 days, with a coefficient of variation of 7.29%. Significant effects on the trait were observed for the herd, the year and the season of birth; but a linear effect of litter size at birth on the age at first farrowing was not observed. The boar did not significantly contribute to the variation occurring among the sows, whereas the sow's mother caused significant variation. The heritability estimate for the age at first farrowing was 0.44 ± 0.15, which is considered high. We concluded that herd effect and year and season of birth should be taken into consideration for an accurate genetic comparison; consequently, the animals should be joined into contemporary groups. ; We acknowledge the collaboration of the Canalli brothers representing the pig farm São José in Monte Alto, SP, Brazil, and of Mr. Adriano Muniz representing the pig farm São José in Cabo Verde, MG, Brazil, who kindly provided the data that allowed this research to be performed. A. Calvacante-Neto was supported by a grant from Fundação para a Ciência e Tecnologia (FCT-MCT; SFRH/BD/47821/2008) and from the ALBAN Programme, the European Union Programme of High Level Scholarships for Latin America (Scholarship #E07D402597BR). ; published

Fundação para a Ciência e a Tecnologia (FCT) ; ALBAN ; European Union ; FCT: SFRH/BD/47821/2008 ; European Union: E07D402597BR ; We evaluated genetic and environmental factors affecting age at first farrowing of sows in the Brazilian southeast. For this purpose, 466 observations regarding the age at first farrowing were made for Dalland-C40 (c) animals belonging to two herds. The effects of the environmental factors on this trait were assessed by means of a model that included, as random effects, the influence of the sow's father and mother and, as fixed effects, the influence the year of birth, the herd and the birth season, along with the covariable litter size at birth. The variance components were estimated using the derivative-free restricted maximum likelihood method. The estimated mean was 354.8 +/- 25.87 days, with a coefficient of variation of 7.29%. Significant effects on the trait were observed for the herd, the year and the season of birth; but a linear effect of litter size at birth on the age at first farrowing was not observed. The boar did not significantly contribute to the variation occurring among the sows, whereas the sow's mother caused significant variation. The heritability estimate for the age at first farrowing was 0.44 +/- 0.15, which is considered high. We concluded that herd effect and year and season of birth should be taken into consideration for an accurate genetic comparison; consequently, the animals should be joined into contemporary groups.