In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles : a potential approach for chronic diseases treatment
© 2020 Fonseca-Gomes et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. ; Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected. ; This work was financially supported by: 1) Base Funding - UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE – funded by national funds through the Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) (PIDDAC) funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES; 2) Santa Casa da Misericórdia de Lisboa (MB37-2017); 3) European Union's Horizon 2020 research and innovation programme under grant agreement No 810685 (DelNAM). FCT supported J.F.G. (SFRH/PD/BD/114441/2016); S.R.T. (SFRH/PD/BD/128091/2016) and J.A.L under the Scientific Employment Stimulus – Institutional Call – [CEECINST/00049/2018]. ; info:eu-repo/semantics/publishedVersion