Suchergebnisse

Reden und Schreiben, dieser vielseitige Gebrauch des Wortes als Waffe und als analytisches Werkzeug für große Bücher und Essays, zeichnen Helmut Schmidt aus vor vielen deutschen Kollegen des politischen Handwerks. Schreibende Politiker haben in Deutschland keine beständige Tradition. Erinnerungen wer den natürlich geschrieben, ebenso wie Bücher zu Wahlkampfzeiten oder auch längere Einwürfe zu jeweils aktuellen Streitfragen. Aber das ist nicht jenes Schreiben aus Leidenschaft, es ist nicht Schreiben, um selbst besser zu verstehen und verständlicher zu machen, was man erkannt hat. Diese Leidenschaft war und ist bei aktiven Politikern in Deutschland eher selten. Bebel fällt einem ein und Rathenau natürlich oder auch Willy Brandt. (...) Diese minutiöse Bibliographie seiner Schriften ist nicht nur eine Wegmarkierung des politischen Lebens von Helmut Schmidt; sie lässt sich auch als ein Kalender zeitgeschichtlicher Ereignisse seit 1947 lesen. Sie hilft zu verstehen, wie sich die politische Welt in den vergangenen sechzig Jahren entfaltete. Und sie lässt erkennen, dass Deutschland in diesen Jahrzehnten von einem tatkräftigen Politiker, politischen Denker und Schriftsteller wichtige Weichenstellungen, Ratschläge und Mahnungen erhielt, die lehrreich sein können auch für die kommenden Jahrzehnte.(Klaus von Dohnanyi im Vorwort).(Quelle: Rückentext Verlagseinband).

Measuring cortisol in hair is a promising method to assess long-term alterations of the biological stress response system, and hair cortisol concentrations (HCC) may be altered in psychiatric disorders and in subjects suffering from chronic stress. However, the pattern of associations between HCC, chronic stress and mental health require clarification. Our exploratory study: (1) assessed the association between HCC and perceived stress, symptoms of depression and neuroticism, and the trait extraversion (as a control variable); and (2) made use of the twin design to estimate the genetic and environmental covariance between the variables of interest. Hair samples from 109 (74 female) subjects (age range 12–21 years, mean 15.1) including 8 monozygotic (MZ) and 21 dizygotic (DZ) twin pairs were analyzed. Perceived stress was measured with the Perceived Stress Scale and/or the Daily Life and Stressors Scale, neuroticism, and extraversion with the NEO-Five Factor Inventory or the Junior Eysenck Personality Questionnaire, and depressive symptoms with the Somatic and Psychological Health Report. We found a modest positive association between HCC and the three risk factors — perceived stress, symptoms of depression, and neuroticism (r = 0.22–0.33) — but no correlation with extraversion (-0.06). A median split revealed that the associations between HCC and risk factors were stronger (0.47–0.60) in those subjects with HCC >11.36 pg/mg. Furthermore, our results suggest that the genetic effects underlying HCC are largely shared with those that influence perceived stress, depressive symptoms, and neuroticism. These results of our proof of principle study warrant replication in a bigger sample but raise the interesting question of the direction of causation between these variables.

This work was supported by Medical Research Council Centre grant MR/ L010305/1, Medical Research Council Program grant MR/P005748/1, and Medical Research Council Project grants MR/L011794/1 and MC_PC_17212 to Cardiff University and by the National Centre for Mental Health, funded by the Welsh Government through Health and Care Research Wales. This work acknowledges the support of the Supercomputing Wales project, which is partially funded by the European Regional Development Fund via the Welsh Government. Dr Pardiñas was supported by an Academy of Medical Sciences Springboard Award (SBF005\1083). Dr Andreassen was supported by the Research Council of Norway (grants 283798, 262656, 248980, 273291, 248828, 248778, and 223273); KG Jebsen Stiftelsen, South-East Norway Health Authority, and the European Union's Horizon 2020 Research and Innovation Programme (grant 847776). Dr Ajnakina was supported by an National Institute for Health Research postdoctoral fellowship (PDF-2018-11-ST2-020). Dr Joyce was supported by the University College London Hospitals/UCL University College London Biomedical Research Centre. Dr Kowalec received funding from the European Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement (793530) from the government of Canada Banting postdoctoral fellowship programme and the University of Manitoba. Dr Sullivan was supported by the Swedish Research Council (Vetenskapsrådet, D0886501), the European Union's Horizon 2020 programme (COSYN, 610307) and the US National Institute of Mental Health (U01 MH109528 and R01 MH077139). The Psychiatric Genomics Consortium was partly supported by the National Institute Of Mental Health (grants R01MH124873). The Sweden Schizophrenia Study was supported by the National Institute Of Mental Health (grant R01MH077139). The STRATA consortium was supported by a Stratified Medicine Programme grant to Dr MacCabe from the Medical Research Council (grant MR/L011794/1), which funded the research and supported Drs Pardiñas, ...