An evolutionary perspective of regulatory landscape dynamics in development and disease
Trabajo aceptado en espera de su publicación. ; The organization of animal genomes into topologically associating domains (TADs) provides a structural scaffold in which cis-regulatory elements (CREs) operate on their target genes. Determining the position of CREs and genes relative to TADs has become instrumental to trace gene expression changes during evolution and in diseases. Here we will review recent studies and discuss TADs as structural units with respect to their conservation and stability during genome reorganization. Furthermore, we describe how TAD restructuring contributed to morphological novelties during evolution but also their deleterious effects associated with disease. Despite considering TADs as structural units, the nested and dynamic scaffold within TADs contribute to tissue-specific gene expression, implying that such changes can also contribute to gene expression differences during evolution. ; This work was supported by the Spanish government [grants BFU2016-74961-P and BFU2016-81887-REDT], the Andalusian Government [grant BIO-396] and the European Union's Horizon 2020 research and innovation programmes European Research Council (ERC) [grant agreement # 740041] to J.L.G.S. and the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement [#800396] to M.F. ; No