Suchergebnisse

SUMARIO: 1. Introducción - 2. Fundamento de los derechos que asisten al paciente de los servicios públicos de sanidad – 3. Libertad de conciencia versus asistencia sanitaria pública - 4. ¿Tiene el Testigo de Jehová derecho al reintegro de los gastos médicos? – 4.a. La asistencia sanitaria concebida como un servicio público esencial – 4.b. Delimitación conceptual de la "denegación injustificada de asistencia sanitaria" – 4.c. La denegación injustificada de asistencia en el ordenamiento jurídico español - 4.d. La situación de los Testigos de Jehová: ¿un supuesto de denegación injustificada de asistencia médica? - 5. Valoración jurisprudencial del conflicto de derechos – 5.a. Resolución del conflicto por el Tribunal Constitucional – 5.b. Resolución del conflicto por el Tribunal Supremo – 5.c. Posicionamiento de los Tribunales Superiores de Justicia - 6. Conclusiones

<p>Migration processes suppose increasing challenges so not only related to the social integration of the people who star in, but also linked to the need to articulate coexistence in the framework of the cultural diversity that creates this phenomenon. To the person who migrates, their identity references are one of the most important elements in joining the new reality that is called to live and, in many cases, represent a fundamental piece for inclusion in the host society. Therefore, these hallmarks form a system of personal and group values have extraordinary importance for those who share and found recognition and protection of democratic systems.</p><p><strong>Published online</strong>: 11 December 2017</p>

onstatada la diferencia que existía entre el régimen de cotización a la Seguridad Social del clero diocesano y del resto de ministros de culto incorporados al sistema público de protección social a través de la figura de la asimilación a trabajadores por cuenta ajena, esta materia ha experimentado una profunda transformación a la luz de las últimas reformas legislativas operadas tras el pronunciamiento de TEDH. Esto ha dado lugar a una la progresiva equiparación de los ministros de culto y los dirigentes religiosos de las distintas confesiones por lo que se refiere al régimen de cotización para la percepción de determinadas prestaciones sociales, especialmente en relación a la pensión de jubilación y las de incapacidad permanente, muerte y supervivencia.

The cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, we administered synthetic nucleosides for varying periods of time to mice at different stages of postnatal development and monitored the rate of uptake of these nucleosides in the different mammary cell compartments. Here we show that most cell division in the adult virgin gland is restricted to the oestrogen receptor-expressing luminal cell lineage. Our data also demonstrate that the oestrogen receptor-expressing, milk and basal cell subpopulations have telomere lengths and cell division kinetics that are not compatible with these cells being hierarchically organized; instead, our data indicate that in the adult homeostatic gland, each cell type is largely maintained by its own restricted progenitors. We also observe that transplantable stem cells are largely quiescent during oestrus, but are cycling during dioestrus when progesterone levels are high. ; We thank the members of Stingl lab, Doug Winton, Jason Carroll, Robert Clarke, Phil Jones and Hamid Raza Ali for scientific discussions. We thank the core facilities at the Cancer Research UK-CI for enabling experiments. In particular, Loic Tauzin, Nina Lane and Mateuz Strzelecki for assistance with cell sorting; the Biological Resources Unit for animal husbandry; and Histopathology staff, in particular Leigh-Anne McDuffus and Cara Walters. J. Stingl's laboratory acknowledges the support of The University of Cambridge, Cancer Research UK (core grant number C14303/A17197) and Hutchison Whampoa Limited. M.A. Blasco's laboratory is funded by the Spanish Ministry of Economy and Competitiveness Project SAF2013-45111RETOS, the European Union FP7 Project EUROBATS, the European Research Council (ERC) Project TEL STEM CELL (GA#232854), the Regional Government of Madrid project 2+2 ReCaRe, the AXA Research Fund and the Fundación Botín. ; This is the final version of the article. It was first available from Nature via http://dx.doi.org/10.1038/ncomms9487

The cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, we administered synthetic nucleosides for varying periods of time to mice at different stages of postnatal development and monitored the rate of uptake of these nucleosides in the different mammary cell compartments. Here we show that most cell division in the adult virgin gland is restricted to the oestrogen receptor-expressing luminal cell lineage. Our data also demonstrate that the oestrogen receptor-expressing, milk and basal cell subpopulations have telomere lengths and cell division kinetics that are not compatible with these cells being hierarchically organized; instead, our data indicate that in the adult homeostatic gland, each cell type is largely maintained by its own restricted progenitors. We also observe that transplantable stem cells are largely quiescent during oestrus, but are cycling during dioestrus when progesterone levels are high. ; We thank the members of Stingl lab, Doug Winton, Jason Carroll, Robert Clarke, Phil Jones and Hamid Raza Ali for scientific discussions. We thank the core facilities at the Cancer Research UK-CI for enabling experiments. In particular, Loic Tauzin, Nina Lane and Mateuz Strzelecki for assistance with cell sorting; the Biological Resources Unit for animal husbandry; and Histopathology staff, in particular Leigh-Anne McDuffus and Cara Walters. J. Stingl's laboratory acknowledges the support of The University of Cambridge, Cancer Research UK (core grant number C14303/A17197) and Hutchison Whampoa Limited. M.A. Blasco's laboratory is funded by the Spanish Ministry of Economy and Competitiveness Project SAF2013-45111RETOS, the European Union FP7 Project EUROBATS, the European Research Council (ERC) Project TEL STEM CELL (GA#232854), the Regional Government of Madrid project 2 + 2 ReCaRe, the AXA Research Fund and the Fundacion Botin. ; Sí

14 páginas, 7 figuras. ; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. ; Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron–sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination. Increased oxidative damage or deficient DNA repair do not account for the observed genomic hyperrecombination. Impaired cell-cycle progression and genetic interactions of ZIM17 with components of the RFC-like complex involved in mitotic checkpoints indicate that replicative stress causes hyperrecombination in zim17Δ mutants. Furthermore, nuclear accumulation of pre-ribosomal particles in zim17Δ mutants reinforces the importance of iron–sulfur clusters in normal ribosome biosynthesis. We propose that compromised ribosome biosynthesis and cell-cycle progression are interconnected, together contributing to replicative stress and nuclear genome instability in zim17Δ mutants. ; European Union (EUROFAN II to A.A.); Spanish Ministry of Science and Innovation (BIO2003-07172 and BIO2006-08051 to R.E.W. and Consolider Ingenio 2010, CSD2007-0015); Junta de Andalucía (P08-CTS-04297 to R.E.W.); Pre-doctoral FPI fellowship from the Spanish Ministry of Science and Innovation (to M.D.L.). Funding for open access charge: Proyecto de investigación de excelencia (P08-CTS-04297) of the Junta de Andalucía. ; Peer reviewed

Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron–sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination. Increased oxidative damage or deficient DNA repair do not account for the observed genomic hyperrecombination. Impaired cell-cycle progression and genetic interactions of ZIM17 with components of the RFC-like complex involved in mitotic checkpoints indicate that replicative stress causes hyperrecombination in zim17Δ mutants. Furthermore, nuclear accumulation of pre-ribosomal particles in zim17Δ mutants reinforces the importance of iron–sulfur clusters in normal ribosome biosynthesis. We propose that compromised ribosome biosynthesis and cell-cycle progression are interconnected, together contributing to replicative stress and nuclear genome instability in zim17Δ mutants. ; European Union (EUROFAN II to A.A.); Spanish Ministry of Science and Innovation (BIO2003-07172 and BIO2006-08051 to R.E.W. and Consolider Ingenio 2010, CSD2007-0015); Junta de Andalucía (P08-CTS-04297 to R.E.W.); Pre-doctoral FPI fellowship from the Spanish Ministry of Science and Innovation (to M.D.L.). Funding for open access charge: Proyecto de investigación de excelencia (P08-CTS-04297) of the Junta de Andalucía.

Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select few tissues. Here we show that human mammary epithelial cells (HMECs) from BRCA1-mutation carriers (BRCA1(mut/+)) exhibit increased genomic instability and rapid telomere erosion in the absence of tumour-suppressor loss. Furthermore, we uncover a novel form of haploinsufficiency-induced senescence (HIS) specific to epithelial cells, which is triggered by pRb pathway activation rather than p53 induction. HIS and telomere erosion in HMECs correlate with misregulation of SIRT1 leading to increased levels of acetylated pRb as well as acetylated H4K16 both globally and at telomeric regions. These results identify a novel form of cellular senescence and provide a potential molecular basis for the rapid cell- and tissue- specific predisposition of breast cancer development associated with BRCA1 haploinsufficiency. ; This work was supported by grants from the Raymond and Beverly Sackler Foundation (M.S.), the Breast Cancer Research Foundation (B.K. and C.K.), the Silvian Foundation (C.K. and A.S.) and the NIH/NCI CA125554 (C.K.), CA092644 (C.K.). Research in the Blasco laboratory was funded by ERC Project Project TEL STEM CELL, FP7 Projects MARK-AGE and EuroBATS, Spanish Ministry of Economy and Competitiveness Projects SAF2008-05384 and CSD2007-00017, Regional of Government of Madrid Project S2010/BMD-2303, AXA Research Fund, Fundacion Botin (Spain) and Fundacion Lilly (Spain). We thank members of the Kuperwasser laboratory for valuable discussions as well as Benjamin Dake, Sarah Phillips and Agueda Tejera for their help with experiments. ; Sí