Suchergebnisse

Esta investigación surge de la necesidad de aportar una herramienta educativa para mejorar la convivencia en el aula, basada en la construcción de las normas del grupo clase con la participación de familias, alumnado y profesorado. Para ello, se construyó y validó un cuestionario formado por un inventario de conductas del alumnado que pueden alterar el adecuado desarrollo de la actividad educativa. Este fue cumplimentado en el pretest y en el postest por 16 alumnos y 8 profesores que conforman el grupo experimental y 18 alumnos y 8 profesores, que constituyen el grupo de control. Posteriormente, se ha desarrollado la intervención en el grupo experimental, consistente en un proceso de elaboración de las normas en el aula. Para ello se han realizado diversas actividades entre las que se incluye un grupo de discusión. Tras la intervención se volvió a pasar el cuestionario (postest), obteniéndose una mejora significativa de los comportamientos objeto de intervención. ; This research stems from the necessity to come up with an educational tool to improve the coexistence in the classroom. It is based on the building of the rules of the class group with the participation of families, students and teachers. For this, a questionary activity was built and validated. It was made up of some students' behaviors items which can upset the development of the educational activity properly. This was filled in the pretest and the postest by 18 students and 8 teachers that made up the experimental group and by 18 students and 8 teachers in the control group. The pretest aim is to characterize the behaviors in which the teachers and students agree in which are occurred more frequently in each group. Afterwards, an intervention was developed within the experimental group through a process of building the rules in the classroom. For this, some activities have been developed, among them a discussion group. After the intervention, the questionary was filled in newly (postest), resulting in a significant improvement of intervention . ; peerReviewed

The knowledge of the genetic variability of the local population is of utmost importance in personalized medicine and has been revealed as a critical factor for the discovery of new disease variants. Here, we present the Collaborative Spanish Variability Server (CSVS), which currently contains more than 2000 genomes and exomes of unrelated Spanish individuals. This database has been generated in a collaborative crowdsourcing effort collecting sequencing data produced by local genomic projects and for other purposes. Sequences have been grouped by ICD10 upper categories. A web interface allows querying the database removing one or more ICD10 categories. In this way, aggregated counts of allele frequencies of the pseudo-control Spanish population can be obtained for diseases belonging to the category removed. Interestingly, in addition to pseudo-control studies, some population studies can be made, as, for example, prevalence of pharmacogenomic variants, etc. In addition, this genomic data has been used to define the first Spanish Genome Reference Panel (SGRP1.0) for imputation. This is the first local repository of variability entirely produced by a crowdsourcing effort and constitutes an example for future initiatives to characterize local variability worldwide. CSVS is also part of the GA4GH Beacon network. CSVS can be accessed at: http://csvs.babelomics.org/. ; Spanish Ministry of Economy and Competitiveness [SAF2017-88908-R, PT17/0009/0006 to J.D.; PI19/00321 and CIBERER ACCI-06/07/0036 to C.A., PI14-948, PI171659 and CIBERER ACCI-06/07/0036 to M.A.M.P.]; Regional Government of Madrid, RAREGenomicsCM [B2017/BMD-3721 to C.A. and B2017/BMD3721 to M.A.M.P.]; all co-funded with European Regional Development Funds (ERDF) as well as EU H2020INFRADEV-1-2015-1 ELIXIR-EXCELERATE [676559]; University Chair UAM-IIS-FJD of Genomic Medicine and the Ramon Areces Foundation also supported this work. Funding for open access charge: Spanish Ministry of Economy and Competitiveness [SAF2017-88908-R]. ; Sí

The knowledge of the genetic variability of the local population is of utmost importance in personalized medicine and has been revealed as a critical factor for the discovery of new disease variants. Here, we present the Collaborative Spanish Variability Server (CSVS), which currently contains more than 2000 genomes and exomes of unrelated Spanish individuals. This database has been generated in a collaborative crowdsourcing effort collecting sequencing data produced by local genomic projects and for other purposes. Sequences have been grouped by ICD10 upper categories. A web interface allows querying the database removing one or more ICD10 categories. In this way, aggregated counts of allele frequencies of the pseudo-control Spanish population can be obtained for diseases belonging to the category removed. Interestingly, in addition to pseudo-control studies, some population studies can be made, as, for example, prevalence of pharmacogenomic variants, etc. In addition, this genomic data has been used to define the first Spanish Genome Reference Panel (SGRP1.0) for imputation. This is the first local repository of variability entirely produced by a crowdsourcing effort and constitutes an example for future initiatives to characterize local variability worldwide. CSVS is also part of the GA4GH Beacon network. CSVS can be accessed at: http://csvs.babelomics.org/. ; Spanish Ministry of Economy and Competitiveness [SAF2017-88908-R, PT17/0009/0006 to J.D.; PI19/00321 and CIBERER ACCI-06/07/0036 to C.A., PI14-948, PI17-1659 and CIBERER ACCI-06/07/0036 to M.A.M.P.]; Regional Government of Madrid, RAREGenomics-CM [B2017/BMD-3721 to C.A. and B2017/BMD3721 to M.A.M.P.]; all co-funded with European Regional Development Funds (ERDF) as well as EU H2020-INFRADEV-1-2015-1 ELIXIR-EXCELERATE [676559]; University Chair UAM-IIS-FJD of Genomic Medicine and the Ramon Areces Foundation also supported this work. Funding for open access charge: Spanish Ministry of Economy and Competitiveness [SAF2017-88908-R]. ; Peer reviewed