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The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world's population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A massive proteomic analysis has revealed that one of the structural proteins of the virus, the E protein, interacts with BRD2 and BRD4 proteins of the Bromodomain and Extra Terminal domain (BET) family of proteins. BETs are essential to cell cycle progression, inflammation and immune response and have also been strongly associated with infection by different types of viruses. The fundamental role BET proteins play in transcription makes them appropriate targets for the propagation strategies of some viruses. Recognition of histone acetylation by BET bromodomains is essential for transcription control. The development of drugs mimicking acetyl groups, and thereby able to displace BET proteins from chromatin, has boosted interest on BETs as attractive targets for therapeutic intervention. The success of these drugs against a variety of diseases in cellular and animal models has been recently enlarged with promising results from SARS-CoV-2 infection studies. ; Research at M.G.-D. lab is currently supported by grants PGC2018-094232-B-I00 from Ministry of Science, Innovation and Universities (MICIU), Spain, and CV20-93141 from regional government from Andalusia (both co-financed by the European Regional Development Fund). ; Peer reviewed

Etxaniz, Usue et al. ; Resident neural precursor cells (NPCs) have been reported for a number of adult tissues. Understanding their physiological function or, alternatively, their activation after tissue damage or in vitro manipulation remains an unsolved issue. Here, we investigated the source of human dermal NPCs in adult tissue. By following an unbiased, comprehensive approach employing cell-surface marker screening, cell separation, transcriptomic characterization, and in vivo fate analyses, we found that p75NTR+ precursors of human foreskin can be ascribed to the Schwann (CD56+) and perivascular (CD56-) cell lineages. Moreover, neural differentiation potential was restricted to the p75NTR+CD56+ Schwann cells and mediated by SOX2 expression levels. Double-positive NPCs were similarly obtained from human cardiospheres, indicating that this phenomenon might be widespread ; This work was financed by grants provided by Ministerio de Economía y Competitividad (Instituto de Salud Carlos III [PI13/02172; PI10/ 02871] and INNPACTO [IPT-300000-2010-17] programs), Diputacio´n Foral de Gipuzkoa (OF 30/2014, OF 98/2012, 53/2011, and 94/2008), the European Union (Poctefa-Interreg-IV-A; Refbio13/ Biod/009), and Gobierno Vasco (Saio12-PE12BN010; Saio10- PE10BF01). A.P.-S.V., U.E., and H.I. received studentships from the Department of Education, University and Research of the Basque Government (BFI08-150, BFI10-262, and PRE2013-1-1068, respectively). A.I. was supported by the ''Programa I3SNS'' (CES09/015) from Instituto de Salud Carlos III and by Osakidetza (Spain) ; Peer Reviewed