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This paper aims to analyse the determinants of transport costs and to investigate their influence in international trade with a sample of disaggregate trade data. First, we estimate a transport cost function using cross-section data on maritime and overland transport for four sectors: agro-industry, ceramic tiles, motor vehicle parts and accessories, and electrical and mechanical household appliances, obtained from interviews held with Spanish exporters and logistics operators in 2001. Second, we study the relationship between transport costs and trade and estimate the elasticity of trade with respect to transport costs for each sector. Important differences for high and low value-added sectors are observed. The trade equation estimation shows that higher transport costs significantly deter trade, especially in high value-added sectors.

Solemos utilizar el concepto de éxito como antagónico de fracaso considerando solamente indicadores de fácil cuantificación, con la escasa autocrítica al reduccionismo que supone esta opción. Entonces, nos preguntamos ¿qué significa tener éxito escolar? El artículo pretende profundizar en la comprensión de éste fenómeno en nuestro contexto. En primer lugar, se analizan cuáles son los fines comunes de la educación expresados en los preámbulos de las diversas leyes de educación desarrolladas en el período democrático en nuestro país desde la Constitución española de 1978. En segundo lugar, centrándonos en trabajos de investigación sobre esta temática en nuestro territorio, identificamos las diferentes representaciones de los conceptos de éxito y fracaso escolar y cómo se llega a un criterio de medida para valorarlos. A partir de este doble análisis se pone de relieve que mayoritariamente los indicadores que se manejan para evaluar el éxito o el fracaso escolar se centran preferentemente en las calificaciones académicas o evaluaciones estandarizadas de diagnóstico de competencias, dejando en segundo término el resto de fines expresados en las leyes de educación, como pueden ser la adquisición de otras calidades personales y sociales. Por esta razón, concluimos el artículo con una propuesta metodológica para el análisis del fenómeno que enfatiza una aproximación multimétodo, para encontrar evidencias de los elementos-causa – en términos de indicadores – que contribuyen al éxito educativo teniendo en cuenta todos los objetivos explícitos en las leyes de educación ; Often educational success is understood as opposed to the concept of school failure. Usually quantifiable indicators are used to measure the phenomena, with little criticism of the reductionism this option poses. In this article we query about how we could assess educational success from a wider perspective in our context. First of all, this study analyses the common principles that appear in the forewords of the different Spanish Education Laws that have been in force during the democratic period in our country since 1978. Secondly, through several research articles about this subject, we identify the different conceptualizations and approaches to measure the phenomena in our territory. The analysis highlights that educational success or failure is mainly measured through indicators that use academic grades or standardized diagnostic tests. Our main finding is that there is a preference to link school success and failure to academic achievement, whereas other goals expressed in the Educational Laws are considered secondary. Therefore, we conclude the article with a methodological proposal to assess educational success from a multi-method approach that takes into account the different objectives explicit in the Educational Laws

The white paper on "Intelligence and Co-creation in Smart Specialisation Strategies" outlines some key conclusions from the Online S3 project, funded under the Horizon 2020 programme of the European Commission. The Online S3 project has produced an online platform composed of software applications and roadmaps that facilitate the design and implementation of Research and Innovation Strategies for Smart Specialisation (RIS3). Using a baseline set of methodologies for strategy design, Online S3 is advancing the understanding of RIS3 as a place-based and evidence-driven innovation policy, relying on large datasets and software for user engagement, co-creation and collective intelligence in policy design. In this white paper, the core building blocks of RIS3 are presented, as they appear in EU documents and related literature, such as ex ante conditionalities, stakeholder engagement, specialisation by diversification, entrepreneurial discovery, policy co-design, monitoring and assessment. This white paper also discusses weaknesses of the current period and what can be done better in the near future; thus, puts RIS3 in retrospect and prospect for 2021-2027. At the same time, it looks into critical dimensions for the next stage of RIS3, focusing on how strategies can be improved by datasets and software, enabling the implementation of complex methods; thus, facilitating collective intelligence and co-creation of solutions, which both are able to usher a transition from the triple to quadruple helix model of collaboration. Finally, the annex presents a short description of the 28 software applications and the 4 roadmaps hosted on the Online S3 Platform, which enable the use of datasets and sophisticated methodologies by policy-makers.

IntroductionInversion of the CD4:CD8 ratio (<1) has been identified as a hallmark of immunosenescence and an independent predictor of mortality in the general population. We aimed to assess the association between the CD4:CD8 ratio and intima‐media thickness (IMT) progression in treated HIV‐infected patients as a marker of early atherosclerosis.Materials and MethodsA longitudinal study during three years was conducted in 120 HIV‐infected patients receiving antiretroviral treatment (ART). We analyzed the associations between the CD4:CD8 ratio, cardiovascular risk factor and antiretroviral (ARV) treatment and progression of subclinical atherosclerosis assessed using carotid IMT at baseline and after three years.ResultsFinally, 96 patients completed the study. Seventy‐six (79.1%) patients were male, aged 44±10 years, 39 (40.6%) were on treatment with Protease inhibitors, 49 (51.04%) with non‐nucleoside reverse transcriptase inhibitors (NNRTI), 6 (6.25%) with integrase inhibitors, 3 (3.12%) with maraviroc and 2 (2.08%) only with nucleoside reverse transcriptase inhibitors (NRTI). The mean of ARV exposition was 6.9±5.9 years. Twenty six (27 %) patients had family history of ischemic heart disease, 51 (53.12%) were smokers, 12 (12.5%) hypertensive, 4 (4.16%) type 2 diabetes, 23 (23.9%) with dyslipidemia and 31 (32.3%) were infected with C hepatitis virus. Baseline IMT was significantly associated with age (rho=0.497; p<0.001), basal glucemia (rho=0.323; p=0.001), triglycerides (rho=0.232; p=0.023), Framingham score (rho=0.324; p=0.001), CD4:CD8 ratio (rho=−0.176; p=0.05) and dyslipidemia (0.72±0.16 mm vs 0.63±0.11 mm; p=0.029). In multivariable analysis where cardiovascular risk factor and ARV were included, IMT progression was inversely associated with CD4:CD8 ratio (OR=0.283; CI 95% 0.099–0.809; p=0.019) and treatment with NNRTI (OR=0.283; CI 95% 0.099–0.809; p=0.019).ConclusionsThe inversion of CD4:CD8 ratio in treated HIV‐infected patients is independently associated with IMT progression, a marker of age‐associated disease. Therefore, it might be clinically useful as predictor of cardiovascular events. Surprisingly, there was a positive correlation between receiving NNRTI and progression of IMT.

We describe the first experimental results in neural machine translation for Basque. As a synthetic language featuring agglutinative morphology, an extended case system, complex verbal morphology and relatively free word order, Basque presents a large number of challenging characteristics for machine translation in general, and for data-driven approaches such as attention-based encoder-decoder models in particular. We present our results on a large range of experiments in Basque-Spanish translation, comparing several neural machine translation system variants with both rule-based and statistical machine translation systems. We demonstrate that significant gains can be obtained with a neural network approach for this challenging language pair, and describe optimal configurations in terms of word segmentation and decoding parameters, measured against test sets that feature multiple references to account for word order variability. ; This work was supported by the Department of Economic Development and Competitiveness of the Basque Government via the MODELA project.

IntroductionNucleoside reverse transcriptase inhibitor (NRTI) is associated with endothelial dysfunction and proinflammatory effects. Maraviroc (MVC) is an antagonist of CCR5 receptor. CCR5 is the receptor of RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), a mediator of chronic inflammation and endothelial function. Our aim was to evaluate the maintenance of viral suppression and improvement of endothelial function in virologically suppressed HIV‐infected patients switched to an NRTI‐sparing combined antiretroviral therapy (cART) with MVC.Materials and MethodsThis observational, non‐interventional, multicenter study was performed at the Infectious Diseases Service of Santa Lucia, Morales Meseguer, Virgen de la Arrixaca and Reina Sofía University Hospital (Murcia, Spain). The selection criteria were to be asymptomatic on a regimen with undetectable viral load (<50 HIV‐RNA copies/mL) for at least six months, no previous treatment with R5 antagonists, no evidence of previous protease inhibitor (PI) failure and available R5 tropism test. Twenty‐one HIV‐infected patients were selected after the treatment regimen was changed to Maraviroc 150 mg/once daily plus ritonavir‐boosted PI therapy. Endothelial function was prospectively evaluated through flow‐mediated dilatation (FMD) of the brachial artery at baseline and at weeks 24.ResultsWe included 21 patients on treatment with PI in combination with 2 NRTI. The mean cART exposition was 133±68.9 months. Fourteen (66.6%) were males, aged 49±9 years, 15 (71.4%) smokers, 4 (19.04%) family history of coronary heart disease, 1 (5.76%) type 2 diabetes and 3 (14.28%) hypertensive, mean total cholesterol was 185.5±35 mg/dL, c‐LDL 100.2±37 mg/dL, tryglicerides 170.42±92.03 mg/dL, cHDL 52.6±15.5 mg/dL, CD4 779,5±383.28 cells/mL, nadir CD4 187,96±96 cells/mL. After 24 weeks of follow‐up of a switch to an NRTI‐sparing regimen, 95.2% of HIV‐patients on viral suppressive cART maintained viral suppression and CD4+ T cell count. This cART switch improve endothelial function in patients with lower baseline FMD levels after 24 weeks (baseline FMD −1.19±4.84 % to 24 weeks FMD 11.32±7.27%; p=0.002).ConclusionsThe results of our study show that a switch to an NRTI‐sparing bi‐therapy with MVC improves endothelial function and maintained the immune‐virologic efficacy. This regimen emphasizes the needs for further clinical studies to associate these achievements with the incidence of non‐AIDS‐defining illnesses.

We describe the European Language Resources Infrastructure project, whose main aim is the provision of an infrastructure to help collect, prepare and share language resources that can in turn improve translation services in Europe. ; Co-financed by the European Union Connecting Europe Facility.