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Despite the predominance of traditional teacher-centered approaches, educators are constantly changing paradigms and social boundaries, by stimulating criticism with active learning based approaches, which are centered on contexts and experiences. Viewing students as individuals enables paradigm changes and inspires new perspectives on established theories and facts. This chapter discusses education in Brazil, with a focus on humane education. Humane education strives to foster compassion and respect for humans, nonhuman animals (hereinafter referred to as animals), and the environment by creating awareness of the needs of others and the effects of our actions. In this chapter we describe the process of humane education in the context of animals used for teaching. We explore the possibilities of replacing animals and including ethical discussions in the curriculum; the history of Brazilian humane education, considering the Environmental Crimes Act that forbids animal use when alternative methods exist; and the legislation that controls the use of animals for research and teaching purposes in Brazil.