Suchergebnisse

Daniel Gibbs is a retired neurologist who was diagnosed with Alzheimer's Disease in 2015. This book presents a hopeful and humane collection of essays written over the past two years about his own experience of navigating the disease and advances in research.

AbstractI use a formal model to analyze the effect of civil service protections on bureaucratic performance. In a two‐period model, a public manager observes a bureaucrat's actions for a period and decides whether to retain or attempt to remove the bureaucrat. Bureaucrats vary in terms of their intrinsic motivation and choose between careers in government or the private sector. I show that bureaucratic performance is greater in any separating equilibrium in which motivated bureaucrats choose government than in all equilibria in which they do not. Stronger civil service protections reduce the amount of effort that motivated bureaucrats must exert to distinguish themselves from their unmotivated peers in order to ensure retention. This strengthens incentives for motivated bureaucrats to choose careers in government. Stronger civil service protections, however, also reduce the ability of public managers to remove unmotivated bureaucrats. These competing effects yield a non‐monotonic and discontinuous relationship between civil service protections and bureaucratic performance. I use the model to analyze recent reforms to U.S. state and federal personnel management that have significantly rolled back traditional job protections.

There is a pressing need to improve job satisfaction among child welfare caseworkers given historically high turnover rates that adversely affect family outcomes. Guided by the job demands-resources model, this study examined whether caseworkers' job satisfaction was associated with their quality of interprofessional collaboration (IPC). Linear regression models were estimated using cross-sectional data provided by the National Child Welfare Workforce Institute. The sample included caseworkers ( N = 1,489) in two states and one urban county in the United States. Results indicated that caseworker job satisfaction increased as their quality of IPC with service providers and court professionals improved. These findings suggest that agency leaders should foster and support IPC as a means of enhancing caseworker job satisfaction.

[EN] Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants. ; M.J.H., S.P.P., D.J.G., G.M.M., J.V.C., and C.S.C. were supported by UK Biotechnology and Biological Sciences Research Council (BBSRC) grants BB/G02488X/1, BB/G010595/1, BB/F006934/1, and BB/K000144/1 (including financial support from SAB Miller plc); J.E.G. was supported by BB/K000063/1; N.M.I. by a MARA PhD fellowship from the Malaysian government; S.B. by a University of Nottingham PhD fellowship; and M.M. by a University of Sheffield Faculty of Science Studentship. D.J.G. was supported by a Nottingham Advanced Research Fellowship for part of this work. J.L.-J., A.C., and J.L. were supported by grants CSD2007-00057 and BIO2011-27526 from the Spanish government. G.W.B. was supported by a Marie Curie IIF Fellowship. The work of A.B. was supported by the Austrian Science foundation FWF (grants P21215 and P25488). Rothamsted Research receives grant-aided support from the BBSRC. D.F.A.T. and J.B. were funded by BBSRC grant ...