The morphing of telecommuting from "home" to "anywhere"
In: Employment relations today, Band 26, Heft 3, S. 67-77
ISSN: 1520-6459
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In: Employment relations today, Band 26, Heft 3, S. 67-77
ISSN: 1520-6459
In: Employment relations today, Band 24, Heft 2, S. 23-32
ISSN: 1520-6459
In: Employment relations today, Band 17, Heft 4, S. 285-290
ISSN: 1520-6459
In: Exchange: The Organizational Behavior Teaching Journal, Band 4, Heft 4, S. 23-25
Cell polarization can be defined as the generation and maintenance of directional cellular organization. The spatial distribution and protein or lipid composition of the cell are not symmetric but organized in specialized domains which allow cells to grow and acquire a certain shape that is closely linked to their physiological function. The establishment and maintenance of polarized growth requires the coordination of diverse processes including cytoskeletal dynamics, membrane trafficking, and signaling cascade regulation. Some of the major players involved in the selection and maintenance of sites for polarized growth are Rho GTPases, which recognize the polarization site and transmit the signal to regulatory proteins of the cytoskeleton. Additionally, cytoskeletal organization, polarized secretion, and endocytosis are controlled by signaling pathways including those mediated by mitogen-activated protein kinases (MAPKs). Rho GTPases and the MAPK signaling pathways are strongly conserved from yeast to mammals, suggesting that the basic mechanisms of polarized growth have been maintained throughout evolution. For this reason, the study of how polarized growth is established and regulated in simple organisms such as the fission yeast Schizosaccharomyces pombe has contributed to broaden our knowledge about these processes in multicellular organisms. We review here the function of the Cdc42 GTPase and the stress activated MAPK (SAPK) signaling pathways during fission yeast polarized growth, and discuss the relevance of the crosstalk between both pathways. ; This work was supported by grants BIO2015-69958-P and BFU2017-82423-P from the Ministry of Science, Innovation and Universities (MICIU) and grants CSI068P17 and Escalera de Excelencia CLU-2017-03 from the Regional Government of Castilla y León (JCyL/FEDER) and the European Regional Development Fund (ERDF).
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In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 95, S. 136-150
ISSN: 1872-7107
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 95, S. 122-135
ISSN: 1872-7107
The aim of this work is to investigate the influence of the addition of Cu on the microstructure and on the microhardness of a laser powder bed fusion (L-PBF)-fabricated AlSi10MgCu alloy. With this goal, AlSi10Mg+4 wt%Cu pre-alloyed powder was produced by gas atomization. Following a parameter optimization study, dense as-built specimens with a high relative density of 99.8% were fabricated. An outstanding microhardness value, exceeding 180 HV, was obtained after aging at 160 °C for 16 h. This value is similar to that of the high strength Al 7075 in the T6 condition. With the aid of analytical transmission electron microscopy, it was concluded that the origin of the observed excellent mechanical behavior could be attributed to the beneficial effect of Cu in reducing the Al-matrix cell size, and in increasing the density and decreasing the size of the Si-based nanoprecipitates at cell interiors. More specifically, it is proposed that the maximum hardness is associated to the development of Cu-rich GP-I zones, which act as precursors of Si nanoprecipitates. Overaging leads to a reduction in microhardness due to transformation of these GP-I zones into coarser θ'' precipitates and thus to a smaller volume fraction of larger Si-based nanoparticles. ; This work was funded by the European Union's Horizon 2020 Clean Sky 2 research and innovation program under grant agreement No 755610, project AlForAMA. The authors acknowledge the support from the topic manager, Leonardo Aircraft. CYW acknowledges the financial support from the Fundamental Research Funds for the Central Universities in China (grant number 3102019QD0415). MTPP would like to acknowledge funding from the Madrid region under the program S2018/NMT-4381-MAT4.0-CM.
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The two PKC orthologs Pck1 and Pck2 in the fission yeast Schizosaccharomyces pombe operate in a redundant fashion to control essential functions, including morphogenesis and cell wall biosynthesis, as well as the activity of the cell integrity pathway and its core element, the MAPK Pmk1. We show here that, despite the strong structural similarity and functional redundancy of these two enzymes, the mechanisms regulating their maturation, activation, and stabilization have a remarkably distinct biological impact on both kinases. We found that, in contrast to Pck2, putative in vivo phosphorylation of Pck1 within the conserved activation loop, turn, and hydrophobic motifs is essential for Pck1 stability and biological functions. Constitutive Pck activation promoted dephosphorylation and destabilization of Pck2, whereas it enhanced Pck1 levels to interfere with proper downstream signaling to the cell integrity pathway via Pck2. Importantly, although catalytic activity was essential for Pck1 function, Pck2 remained partially functional independent of its catalytic activity. Our findings suggest that early divergence from a common ancestor in fission yeast involved important changes in the mechanisms regulating catalytic activation and stability of PKC family members to allow for flexible and dynamic control of downstream functions, including MAPK signaling. ; This work was supported by Ministerio de Economía y Competitividad Grants BFU2014-52828-P and BIO2015-69958-P, Fundación Séneca Grant 19246/PI/14, and European Regional Development Fund co-funding from the European Union. ; Peer reviewed
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BACKGROUND: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, proinflammatory cytokines change brain function in several ways, such as altering neurotransmitters, the glucocorticoid axis, and apoptotic mechanisms. This study aimed to evaluate the impact on mood of initiating IFN-alpha and ribavirin treatment in a cohort of patients with chronic hepatitis C. We investigated clinical, personality, and functional genetic variants associated with cytokine-induced depression. METHODS: We recruited 344 Caucasian outpatients with chronic hepatitis C, initiating IFN-alpha and ribavirin therapy. All patients were euthymic at baseline according to DSM-IV-R criteria. Patients were assessed at baseline and 4, 12, 24, and 48 weeks after treatment initiation using the Patient Health Questionnaire (PHQ), the Hospital Anxiety and Depression Scale (HADS), and the Temperament and Character Inventory (TCI). We genotyped several functional polymorphisms of interleukin-28 (IL28B), indoleamine 2,3-dioxygenase (IDO-1), serotonin receptor-1A (HTR1A), catechol-O-methyl transferase (COMT), glucocorticoid receptors (GCR1 and GCR2), brain-derived neurotrophic factor (BDNF), and FK506 binding protein 5 (FKBP5) genes. A survival analysis was performed, and the Cox proportional hazards model was used for the multivariate analysis. RESULTS: The cumulative incidence of depression was 0.35 at week 24 and 0.46 at week 48. The genotypic distributions were in Hardy-Weinberg equilibrium. Older age (p = 0.018, hazard ratio [HR] per 5 years = 1.21), presence of depression history (p = 0.0001, HR = 2.38), and subthreshold depressive symptoms at baseline (p = 0.005, HR = 1.13) increased the risk of IFN-induced depression. So too did TCI personality traits, with high scores on fatigability (p = 0.0037, HR = 1.17), impulsiveness (p = 0.0200 HR = 1.14), disorderliness (p = 0.0339, HR = 1.11), and low scores on extravagance (p = 0.0040, HR = 0.85). An interaction between HTR1A and COMT genes was found. Patients carrying the G allele of HTR1A plus the Met substitution of the COMT polymorphism had a greater risk for depression during antiviral treatment (HR = 3.83) than patients with the CC (HTR1A) and Met allele (COMT) genotypes. Patients carrying the HTR1A CC genotype and the COMT Val/Val genotype (HR = 3.25) had a higher risk of depression than patients with the G allele (HTR1A) and the Val/Val genotype. Moreover, functional variants of the GCR1 (GG genotype: p = 0.0436, HR = 1.88) and BDNF genes (Val/Val genotype: p = 0.0453, HR = 0.55) were associated with depression. CONCLUSIONS: The results of the study support the theory that IFN-induced depression is associated with a complex pathophysiological background, including serotonergic and dopaminergic neurotransmission as well as glucocorticoid and neurotrophic factors. These findings may help to improve the management of patients on antiviral treatment and broaden our understanding of the pathogenesis of mood disorders. ; This study was funded by the following Spanish grants: Instituto de Carlos III, Fondo de Investigaciones Sanitarias PSICOCITVHC-P110/01827 and PSIGEN-VHC-EC08/00201 (Dr MartínSantos). It was co-financed by the ERDF, European Union "One way to make Europe," Ministerio de Economía y Competitividad (MTM2012-38067-C02-01), and the support of the Generalitat de Catalunya (SGR2009/1435/SGR2014/1411; Dr Martín-Santos). Dr Grande has received a research grant from Río Hortega Contract (CM12/00062), Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness.
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FMSR (Austria) ; FNRS (Belgium) ; FWO (Belgium) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; MES (Bulgaria) ; CERN (China) ; CAS (China) ; MoST (China) ; NSFC (China) ; COLCIENCIAS (Colombia) ; MSES (Croatia) ; RPF (Cyprus) ; Academy of Sciences and NICPB (Estonia) ; Academy of Finland, ME, and HIP (Finland) ; CEA (France) ; CNRS/IN2P3 (France) ; BMBF (Germany) ; DFG (Germany) ; HGF (Germany) ; GSRT (Greece) ; OTKA (Hungary) ; NKTH (Hungary) ; DAE (India) ; DST (India) ; IPM (Iran) ; SFI (Ireland) ; INFN (Italy) ; NRF (Korea) ; LAS (Lithuania) ; CINVESTAV (Mexico) ; CONACYT (Mexico) ; SEP (Mexico) ; UASLP-FAI (Mexico) ; PAEC (Pakistan) ; SCSR (Poland) ; FCT (Portugal) ; JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan) ; MST (Russia) ; MAE (Russia) ; MSTDS (Serbia) ; MICINN ; CPAN (Spain) ; Swiss Funding Agencies (Switzerland) ; NSC (Taipei) ; TUBITAK ; TAEK (Turkey) ; STFC (United Kingdom) ; DOE (USA) ; NSF (USA) ; European Union ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at root s = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(ch)/d eta vertical bar(vertical bar eta vertical bar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date.
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FMSR (Austria) ; Fonds de la Recherche Scientifique (FNRS) ; FWO (Belgium) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; MES (Bulgaria) ; Organisation Européenne pour la Recherche Nucléaire (CERN) ; Chinese Academy of Sciences (CAS) ; MoST, (China) ; National Natural Science Foundation of China (NSFC) ; COLCIENCIAS (Colombia) ; MSES (Croatia) ; Research Promotion Foundation (RPF) ; Academy of Sciences (Estonia) ; National Institute of Chemical Physics and Biophysics (NICPB) ; Academy of Finland ; ME (Finland) ; Helsinki Institute of Physics (HIP) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; Institut national de physique nucléaire et de physique des particules (IN2P3/CNRS) ; Bundesministerium für Bildung und Forschung (BMBF) ; Deutsche Forschungsgemeinschaft (DFG) ; HGF (Germany) ; General Secretariat for Research and Technology (GSRT) ; Hungarian Scientific Research Fund (OTKA) ; NKTH (Hungary) ; Department of Atomic Energy (DAE) - India ; Department of Science and Technology (DST) - India ; Institute for Research in Fundamental Sciences (IPM) ; Science Foundation Ireland (SFI) ; Istituto Nazionale di Fisica Nucleare (INFN) ; National Research Foundation of Korea (NRF) ; WCU (Korea) ; LAS (Lithuania) ; Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV) ; Consejo Nacional de Ciencia y Tecnología (CONACYT) ; SEP, (Mexico) ; UASLP-FAI (Mexico) ; Pakistan Atomic Energy Commission (PAEC) ; SCSR (Poland) ; Fundação para a Ciência e a Tecnologia (FCT) ; Joint Institute for Nuclear Research (JINR) ; MST (Russia) ; MAE (Russia) ; MSTDS (Serbia) ; MICINN (Spain) ; Centro Nacional de Física de Partículas, Astropartículas y Nuclear (CPAN) ; Swiss Funding Agencies (Switzerland) ; NSC (Taipei) ; Scientific and Technological Research Council of Turkey (TUBITAK) ; Türkiye Atom Enerjisi Kurumu (TAEK) ; Science and Technology Facilities Council (STFC) ; DOE (USA) ; National Science Foundation (NSF) - USA ; European Union ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Associazione per lo Sviluppo Scientifico e Tecnologico del Piemonte (Italy) ; A study of forward energy flow and central charged-particle multiplicity in events with W and Z bosons decaying into leptons is presented. The analysis uses a sample of 7 TeV pp collisions, corresponding to an integrated luminosity of 36 pb(-1), recorded by the CMS experiment at the LHC. The observed forward energy depositions, their correlations, and the central charged-particle multiplicities are not well described by the available non-diffractive soft-hadron production models. A study of about 300 events with no significant energy deposited in one of the forward calorimeters, corresponding to a pseudorapidity gap of at least 1.9 units, is also presented. An indication for a diffractive component in these events comes from the observation that the majority of the charged leptons from the W(Z) decays are found in the hemisphere opposite to the gap. When fitting the signed lepton pseudorapidity distribution of these events with predicted distributions from an admixture of diffractive (POMPYT) and non-diffractive (PYTHIA) Monte Carlo simulations, the diffractive component is determined to be (50.0 +/- 9.3 (stat.) +/- 5.2 (syst.))%.
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