Suchergebnisse

Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (Danio rerio) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems. ; This research was supported in part by the Spanish MICINN (project grant PID2019-104739GB-100/AEI/10.13039/501100011033) from the Government of Aragon (project DGA E13-20R). ; Peer reviewed

Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes. ; Istituto Italiano di Tecnologia (IIT) ; COST Action [CA 15107] ; People Program (Marie Curie Actions) of the European Union's Seventh Framework Program under REA [606713 BIBAFOODS] ; Portuguese Foundation for Science and Technology (FCT) [PTDC/AGR-TEC/4814/2014, IF/01005/2014] ; Fundacao para a Ciencia e Tecnologia [SFRH/BPD/99982/2014] ; Danish National Research Foundation [DNRF 122] ; Villum Foundation [9301] ; Italian Ministry of Instruction, University and Research (MIUR), PRIN [20109PLMH2] ; "Fondazione Beneficentia Stiftung" Vaduz ; Fondo di Ateneo FRA ; FRA ; info:eu-repo/semantics/publishedVersion