Suchergebnisse

Genetics and machine learning can improve blood transfusion outcomes
The availability of blood for blood transfusion support is critical for the delivery of medical care. When a person donates blood, it is separated into different components: red cells, platelets, white cells and plasma. Better blood transfusion outcomes for patients and better protection of the NHS blood supply can be achieved with machine learning, argue Drs Samuel McDermott, Nicholas Gleadall and Sara Trompeter. Red cell transfusion is used to treat patients who have lost red cells due to trauma or surgery or who are unable to make healthy red cells. To support over 500,000 transfusions annually, NHSBT issues 1.4 million blood units collected from 800,000 donors.

$\textit{Staphylococcus aureus}$ carriers are at higher risk of $\textit{S. aureus}$ infection and are a reservoir for transmission to others. Detection of nasal $\textit{S. aureus}$ carriage is important for both targeted decolonization and epidemiological studies. Self-administered nasal swabbing has been reported previously, but the effects of posting swabs prior to culture on $\textit{S. aureus}$ yield have not been investigated. A longitudinal cohort study was performed in which healthy volunteers were recruited, trained in the swabbing procedure and asked to take weekly nasal swabs for 6 weeks (median: 3 weeks, range 1-6 weeks). Two swabs were taken at each sampling episode and randomly assigned for immediate processing on arrival to the laboratory (Swab A) or second class postage prior to processing (Swab B). $\textit{S. aureus}$ was isolated using standard methods. A total of 95 participants were recruited, who took 944 swabs (472 pairs) over a median of 5 weeks. Of these, 459 swabs were positive for $\textit{S. aureus}$. We found no significant difference (P=0.25) between 472 pairs of nasal self-swabs processed immediately or following standard postage from 95 study participants (51.4 % vs. 48.6 %, respectively). We also provide further evidence that persistent carriers can be detected by two weekly swabs with high degrees of sensitivity [92.3 % (95 % CI 74.8-98.8 %)] and specificity [95.6 % (95 % CI 84.8-99.3 %)] compared with a gold standard of five weekly swabs. Self-swabbing and postage of nasal swabs prior to processing has no effect on yield of $\textit{S. aureus}$, and could facilitate large community-based carriage studies. ; This work was supported by UKCRC Translational Infection Research (TIR) Initiative and the Medical Research Council (Grant Number G1000803) with contributions to the Grant from the Biotechnology and Biological Sciences Research Council, the National Institute for Health Research on behalf of the Department of Health, and the Chief Scientist Office of the Scottish Government Health Directorate and by a Medical Research Council Partnership grant (G1001787/1) held between the Department of Veterinary Medicine, University of Cambridge (M. A. H.), the School of Clinical Medicine, University of Cambridge (S. J. P.), the Moredun Research Institute and the Wellcome Trust Sanger Institute.