Plant catalases as NO and H2S targets
SGG acknowledges a 'Formación de Personal Investigador' contract from the Ministry of Economy and Competitiveness, Spain. ; Catalase is a powerful antioxidant metalloenzyme located in peroxisomes which also plays a central role in signaling processes under physiological and adverse situations. Whereas animals contain a single catalase gene, in plants this enzyme is encoded by a multigene family providing multiple isoenzymes whose number varies depending on the species, and their expression is regulated according to their tissue/organ distribution and the environmental conditions. This enzyme can be modulated by reactive oxygen and nitrogen species (ROS/RNS) as well as by hydrogen sulfide (H2S). Catalase is the major protein undergoing Tyr-nitration [post-translational modification (PTM) promoted by RNS] during fruit ripening, but the enzyme from diverse sources is also susceptible to undergo other activity-modifying PTMs. Data on S-nitrosation and persulfidation of catalase from different plant origins are given and compared here with results from obese children where S-nitrosation of catalase occurs. The cysteine residues prone to be S-nitrosated in catalase from plants and from bovine liver have been identified. These evidences assign to peroxisomes a crucial statement in the signaling crossroads among relevant molecules (NO and H2S), since catalase is allocated in these organelles. This review depicts a scenario where the regulation of catalase through PTMs, especially S-nitrosation and persulfidation, is highlighted. ; European Union (EU) ; Spanish Government AGL2015-65104-P PID2019103924GB-I00 ; Plan Andaluz de Investigacion, Desarrollo e Innovacion P18-FR-1359 ; Junta de Andalucia BIO 192 ; Health Strategy Action (Spain's National Plan for Science and Technology Research, Development and Innovation) PI18-01316