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The idea of"transparency" crosses epistemological, sociological, cultural and even political areas and it maintains, in contemporaneity, a privileged place for inquire and significance. Through the passage from opaque to transparency, by means of diverse and gradual degrees of translucence, it is possible to symbolise the creative process in contemporary art and architecture and its repercussions for a gnoseological domain. Interpreting transparency as a mediating and dynamic entity, we intend to research in modes of understanding for both its material (literal) and metaphorical (virtual) 'use' in art and architecture. These accomplish, by means of material choices and formal, functional and aesthetic transformations, a framework where it is possible to observe the passage from a crystalline state to an environmental one. The opacity/transparency duality addresses, through a plurality of meanings along time, the visible/invisible problem – or, in another reading, the one concerning appearance/meaning. Intrinsic question of both artistic and architectural creations and their meaning, transparency assumes a simultaneously dynamic and discrete statute, transcending what emerges from the work, and can be related to virtuality and even dissolution, from the visuality to others domains.

Abstract Human‐wildlife conflict has hindered the success of many management measures for the conservation of endangered species. Therefore, this study aims to establish which non-human species are in conflict with human beings and to understand how residents perceive
human‐wildlife conflict, and how they proceed when in conflict with non-human animals, in the municipality of Santa Comba Dão. The author conducted unstructured interviews with the residents of this county on the subjects of locally existing and extinct species, and problems
with amphibians, birds, fish, mammals and reptiles. In this study, the author found non-human species to be in conflict with human beings, with residents blaming them for economic losses. Foxes, for example, were accused of preying on farm animals. However, the residents also identified the
construction of roads and the introduction of exotic species as economic activities that adversely affected native species. Interviewees also reported conflicts of interest between local hunters and farmers as the hunters' associations had introduced wild boar to the area, a species that consumes
farmers' white potatoes and corn. Residents' perceptions were in part influenced by the local citizens' beliefs and values ‐ information not previously evaluated in this area. This type of information may be extremely useful during the planning of policy measures, given its importance
to establishing effective public policies that protect biodiversity and improve sustainable development.

Organised crime groups are traditionally understood as being composed of men, with a rigid hierarchical structure and well-divided tasks. However, recent studies have been showing that criminal networks (horizontal structure) are increasingly common and even an alternative to the typical rigid structure in organized crime, which allows for a more flexible, dynamic, and adaptive criminal group. Moreover, women are progressively present in such groups, especially in drug trafficking groups, and, in some cases, play relevant roles inside those criminal organisations. In this study, criminal court files related to trafficking organised crime groups involving one hundred defendants were analysed by applying criminal network analyses techniques. The objective was to examine the participation and centrality of women in the functioning of the drug trafficking groups. The findings show that women have a significant presence within these networks, play important roles inside the criminal networks and enjoy of high centrality positions, being some of them decisive key players in the functioning of the group.

"In the field of victimology, the landscape of victimization is constantly evolving, presenting new challenges and demands. The traditional approaches to understanding and addressing victimization are often inadequate in capturing the complex and nuanced experiences of victims. Furthermore, the justice system and victim support services struggle to keep pace with the changing forms of victimization, leading to gaps in protection and support for victims. There is a critical need for a contemporary approach that comprehensively examines victimization and provides practical insights and solutions for researchers, practitioners, and policymakers.Investigating and Combating Gender-Related Victimization offers a pioneering solution to the challenges posed by modern victimization. By focusing exclusively on qualitative studies, this handbook provides a deep and nuanced understanding of victim experiences, interactions with the justice system, and the impact of victimization. The qualitative approach allows for a more holistic examination of victimization, capturing the emotions, narratives, and coping mechanisms of victims often overlooked in quantitative studies."--

"The study of victimization is experiencing profound changes with the introduction of new challenges and demands. From emerging forms of victimization to the continuous evolution of perpetrators' methods, these shifts necessitate critical adjustments of the study at theoretical and practical levels. The scientific community, as well as public communities and institutions of justice grapple with the intricate connections between crime victims and the justice system. Amidst this urgency, there is a distinctive need for a comprehensive resource that not only delves into the complexities of victimology but also addresses the evolving theoretical and practical frameworks shaping the field.Victimization has transformed into unprecedented forms, impacting individuals, communities, and institutions. These changes create a demand for innovative solutions at multiple levels. The scientific community faces the challenge of adapting theoretical approaches, prevention, and intervention strategies to keep pace with evolving victimization methods. Communities and organizations require new protection strategies, particularly in the face of collective victimization. Within justice systems, constant vigilance and adaptation are essential to navigate the complexities of these transformations.Modern Insights and Strategies in Victimology serves as the definitive solution to the pressing challenges presented by the evolving landscape of victimology. Exclusively featuring qualitative studies, the book offers a unique perspective by delving deeply into the lived experiences, narratives, and emotions within the justice system. Through its contemporary and systematic approach, the handbook integrates theoretical approaches with recent empirical studies, emphasizing qualitative methodologies. The book is a testament to its commitment to enriching academic scholarship while providing invaluable insights to victim assistance professionals, policymakers, and decision-makers."--

This journal is © The Royal Society of Chemistry 2020. ; The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with unexploited topological pharmacophore patterns. Importantly, we reveal the first X-ray crystal structure of covalently inhibited BMX at Cys496, which displays key interactions with Lys445, responsible for hampering ATP catalysis and the DFG-out-like motif, typical of an inactive conformation. Molecular dynamic simulations also showed this interaction for two ligand/BMX complexes. Kinome selectivity profiling showed that the most potent compound is the strongest binder, displays intracellular target engagement in BMX-transfected cells with two-digit nanomolar inhibitory potency, and leads to BMX degradation PC3 in cells. The new inhibitors displayed anti-proliferative effects in androgen-receptor positive prostate cancer cells that where further increased when combined with known inhibitors of related signaling pathways, such as PI3K, AKT and Androgen Receptor. We expect these findings to guide development of new selective BMX therapeutic approaches. ; Funded under the Royal Society (URF to G. J. L. B., URF\R\180019), FCT Portugal (iFCT to G. J. L. B., IF/00624/2015, Postdoctoral Fellowship SFRH/BPD/95253/2013 to J. D. S., project PTDC/MED-QUI/28764/2017 to J. D. S., 02/SAICT/2017 grant 28333 to T. R., doctoral studentship SFRH/BD/143583/2019 to B. B. S., and DL 57/2016/CP1451/CT0025 to J. D. S.). This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreements No. 807281 and 702428. The authors acknowledge the Wellcome Trust (104633/Z/14/Z, to D. W. and C. V. R.), Ministerio de Economía y Competitividad (project RTI2018-099592-B-C21 to F. C.), the Royal G. and Mae H. Westaway Family Memorial Fund (A. N. K.), National Science Foundation Graduate Research Fellowship (Grant No ...

Funding: We thank Sabine Baxter for assistance with hybridoma and cell culture at the University of Pennsylvania Perelman School of Medicine Cell Center Services Facility. We acknowledge the use of cryo-EM instruments at Pfizer Inc. The cryo-EM work was supported by a grant from the National Institute of Health (R01GM103899 and R01GM129357 to V.Y.M.-B.). The TRPV2-flag-RFP construct cloned into the pEGFP-N2 vector was kindly provided by Prof. Kojima (Gunma University, Japan). The Developmental Therapeutics Program is acknowledged for screening PL against the NCI-60 cancer cell line panel. We are grateful to Carlos Custódia, Eunice Paisana, and Dr. Joao Barata for their assistance with cell-line modulation ̃ and the GBM tumor model, and to Dr. Vikki Cantrill for her assistance with the editing of this manuscript. Figure design by Claudia Flandoli (draw.science). The Histology and Comparative Pathology Laboratory of the Instituto de Medicina Molecular is acknowledged for technical support. We also thank FCT Portugal (FCT Investigator IF/00624/2015 to G.J.L.B., IF/01693/2014 to V.A.M. and IF/00595/2014 to N.L.B.-M., CEECIND/00436/2018 to N.L.B.-M., PhD studentship SFRH/BD/143583/2019 to B.B.S., PhD studentship PD/BD/128289/2017 to E.P.L., Postdoctoral fellowship SFRH/BPD/1187731/2016 to M.C.M.), Agencia Estatal Investigación of Spain (AEI, RTI-2018-099592-B-C21 to F.C.), EMBO (Installation Grant 3057 to N.L.B.-M.), and the Medical Research Council (MR/N010051/1 to P.F.). This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 630731, 675007, 807281, and 743640. G.J.L.B. is a Royal Society University Research Fellow (URF\R\180019). ; The use of computational tools to identify biological targets of natural products with anticancer properties and unknown modes of action is gaining momentum. We employed self-organizing maps to deconvolute the phenotypic effects of piperlongumine (PL) and establish a link to modulation of the human transient receptor potential vanilloid 2 (hTRPV2) channel. The structure of the PL-bound full-length rat TRPV2 channel was determined by cryo-EM. PL binds to a transient allosteric pocket responsible for a new mode of anticancer activity against glioblastoma (GBM) in which hTRPV2 is overexpressed. Calcium imaging experiments revealed the importance of Arg539 and Thr522 residues on the antagonistic effect of PL and calcium influx modulation of the TRPV2 channel. Downregulation of hTRPV2 reduces sensitivity to PL and decreases ROS production. Analysis of GBM patient samples associates hTRPV2 overexpression with tumor grade, disease progression, and poor prognosis. Extensive tumor abrogation and long term survival was achieved in two murine models of orthotopic GBM by formulating PL in an implantable scaffold/hydrogel for sustained local therapy. Furthermore, in primary tumor samples derived from GBM patients, we observed a selective reduction of malignant cells in response to PL ex vivo. Our results establish a broadly applicable strategy, leveraging data-motivated research hypotheses for the discovery of novel means tackling cancer. ; publishersversion ; published