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Poverty is a challenge leading to food insecurity in people's minds. This article discusses food governance as a psychological mechanism to facilitate the sense of wellness in people's minds in the context of tourism poverty alleviation. Mainly, we argue that, when a government is implementing tourism poverty alleviation, not only are economic efforts, but also positive psychological feelings are required. We, thus, argue that sound food governance may increase the sense of wellness in the minds of people as food consumers by increasing food safety and security. This perspective paper contributes by explicating the influences of macrolevel governance design of safer and more secure food systems on people's psychological wellness, especially against the background of tourism poverty alleviation in developing countries.

Despite the volume of China's express delivery is huge, occasionally there will be a lot of security incidents. To this end, the State Post Bureau Office implements the real-name system on November 1, 2015. However, for the reasons that the express delivery enterprises believe the implementation costs are too high, consumers worry the leakage of personal information, the real-name system of express delivery has not been well implemented. The more fundamental reason is that the supervision and management of the government are not strict enough. This article believes that the real-name system can be more effective by strengthening the supervision and management of the real-name system, with high-tech equipment as well as improving relevant laws and regulations.

Ying-dong Cheng, Hua Yang, Guo-qing Chen, Zhi-cao Zhang Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China Abstract: The survival rate of patients with metastatic colorectal cancer (mCRC) has significantly improved with applications of molecularly targeted drugs, such as bevacizumab, and led to a substantial improvement in the overall survival rate. These drugs are capable of specifically targeting the inherent abnormal pathways in cancer cells, which are potentially less toxic than traditional nonselective chemotherapeutics. In this review, the recent clinical information about molecularly targeted therapy for mCRC is summarized, with specific focus on several of the US Food and Drug Administration-approved molecularly targeted drugs for the treatment of mCRC in the clinic. Progression-free and overall survival in patients with mCRC was improved greatly by the addition of bevacizumab and/or cetuximab to standard chemotherapy, in either first- or second-line treatment. Aflibercept has been used in combination with folinic acid (leucovorin)–fluorouracil–irinotecan (FOLFIRI) chemotherapy in mCRC patients and among patients with mCRC with wild-type KRAS, the outcomes were significantly improved by panitumumab in combination with folinic acid (leucovorin)–fluorouracil–oxaliplatin (FOLFOX) or FOLFIRI. Because of the new preliminary studies, it has been recommended that regorafenib be used with FOLFOX or FOLFIRI as first- or second-line treatment of mCRC chemotherapy. In summary, an era of new opportunities has been opened for treatment of mCRC and/or other malignancies, resulting from the discovery of new selective targeting drugs. Keywords: metastatic colorectal cancer (mCRC), antiangiogenic drug, bevacizumab, aflibercept, regorafenib, cetuximab, panitumumab, clinical trial, molecularly targeted therapy

High-quality data are the foundation to monitor the progress and evaluate the effects of road traffic injury prevention measures. Unfortunately, official road traffic injury statistics delivered by governments worldwide, are often believed somewhat unreliable and invalid. We summarized the reported problems concerning the road traffic injury statistics through systematically searching and reviewing the literature. The problems include absence of regular data, under-reporting, low specificity, distorted cause spectrum of road traffic injury, inconsistency, inaccessibility, and delay of data release. We also explored the mechanisms behind the problematic data and proposed the solutions to the addressed challenges for road traffic statistics.

Wu Xu,1 Guo-Qing Hu,1 Clive Da Costa,2 Jun-Hai Tang,3 Qing-Rui Li,4 Lei Du,5 Ya-Wen Pan,6 Sheng-Qing Lv31Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, People's Republic of China; 2Adult Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK; 3Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, People's Republic of China; 4Biobank of Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400037, People's Republic of China; 5Department of Neurosurgery, The 42nd Hospital of the Chinese People's Liberation Army, Leshan City, Sichuan 614100, People's Republic of China; 6Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou 730030, People's Republic of ChinaIntroduction: Brain glioma is the most common type of primary malignancy in the central nervous system (CNS), with high recurrence and mortality rate, especially glioblastoma (GBM). Recent evidence suggests a role for many long noncoding RNAs (lncRNAs) in the pathogenesis, proliferation, apoptosis, metastasis, and chemotherapeutic resistance of cancer cells. Although the functions of some lncRNAs in the occurrence and development of gliomas have been confirmed, detailed mechanisms of action are lacking. Furthermore, the biological roles of many other lncRNAs in glioma have not been reported at all.Methods: In this study, we identified a novel lncRNA, UBE2R2-AS1, which was dramatically downregulated in glioma compared with normal tissue, by performing microarray detection of six pairs of glioma samples and adjacent normal tissues. In vitro experiments demonstrated that UBE2R2-AS1 regulated glioma cell proliferation, apoptosis, and migration.Results: UBE2R2-AS1 acted as a competing endogenous RNA (ceRNA) to target Toll-like receptor 4 (TLR4) mRNA by binding to miR-877-3p. Furthermore, lncRNA UBE2R2-AS1 suppressed glioblastoma cell growth, migration, and invasion, as well as promoting cell apoptosis by targeting miR-877-3p/TLR4 directly.Conclusion: This information regarding UBE2R2-AS1 and its glioma-related molecular mechanisms will aid the future identification of new lncRNA-directed diagnostics and drug-targeting therapies.Keywords: apoptosis, brain glioma, lncRNA, miR-877-3p/TLR4, UBE2R2-AS1