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Queer-feminist engagements aim at transforming sexualized, gendered, classed, and racialized regimes. Given the current turn in the humanities and social sciences towards affect and emotions, how crucial is (reworking) affect for this endeavor and how does affect work in these contexts? Are affects and emotions spontaneous and unruly or are they molded by historically and socially specific dynamics and codes of intelligibility? In what ways are the social, the economic, and the political created, enforced or transformed, for example, by anger, despair, shame, or pleasure? This event interrogated queering affect as work, as something that works, and as something that we can work with.Marie-Luise Angerer is professor for media and cultural studies at the Academy of Media Arts Cologne. Her research and publications focus on affect and media technologies as well as on the entanglement of representation and materiality. Deborah Gould is associate professor of sociology at UC Santa Cruz, currently working on a project that looks at political affinities and reciprocities across chasms of difference. She was involved in ACT UP/Chicago for many years and is a founding member of the research/art/activism collaborative group, Feel Tank Chicago. Encarnación Gutiérrez Rodriguez is professor of sociology at the University Gießen. In her research and publications she engages with questions of the local face of global inequalities, queer-feminist decolonial epistemology, and critical intersectional approaches to migration and diaspora studies. ; Reworking Affect Queer-Feminist Engagements , workshop, ICI Berlin, 27 June 2013

This article belongs to the Special Issue Novel Biomarkers for Heart Disease. ; Restoration of epicardial coronary blood flow, achieved by early reperfusion with primary percutaneous coronary intervention (PPCI), is the guideline recommended to treat patients with ST-segment-elevation myocardial infarction (STEMI). However, despite successful blood restoration, increasing numbers of patients develop left ventricular adverse remodelling (LVAR) and heart failure. Therefore, reliable prognostic biomarkers for LVAR in STEMI are urgently needed. Our aim was to investigate the role of circulating microRNAs (miRNAs) and their association with LVAR in STEMI patients following the PPCI procedure. We analysed the expression of circulating miRNAs in blood samples of 56 patients collected at admission and after revascularization (at 3, 6, 12 and 24 h). The associations between miRNAs and left ventricular end diastolic volumes at 6 months were estimated to detect LVAR. miRNAs were also analysed in samples isolated from peripheral blood mononuclear cells (PBMCs) and human myocardium of failing hearts. Kinetic analysis of miRNAs showed a fast time-dependent increase in miR-133a, miR-133b, miR-193b, miR-499, and miR-320a in STEMI patients compared to controls. Moreover, the expression of miR-29a, miR-29b, miR-324, miR-208, miR-423, miR-522, and miR-545 was differentially expressed even before PPCI in STEMI. Furthermore, the increase in circulating miR-320a and the decrease in its expression in PBMCs were significantly associated with LVAR and correlated with the expression of miR-320a in human failing myocardium from ischaemic origin. In conclusion, we determined the time course expression of new circulating miRNAs in patients with STEMI treated with PPCI and we showed that miR-320a was positively associated with LVAR. ; This research was funded by the Institute of Carlos III [grant numbers: PI18/01197; PI15/00203; CB16/11/00431]; the Spanish Ministry of Economy and Competitiveness [grant number: BFU2016-74932-C2]; and the Andalusia Government [grant number: PI-0313-2016]. This study was co-financed by FEDER Funds.