Suchergebnisse

1. Preclinical Ischemia Model Systems -- 1. Primary Cultures for Testing Neuroprotective Drugs -- 2. Modeling Neurodegeneration and Neuroprotection in Hippocampal Slices -- 3. Stroke Models for Preclinical Trials of Neuroprotective Agents -- 4. Animal Models of Ischemia -- 5. Head Trauma Model Systems -- 2. Neuroprotective Approaches in Stroke and Head Trauma -- 6. Excitotoxicity, Cerebral Ischemia, and Neuroprotection by Competitive NMDA Receptor Antagonists -- 7. Excitatory Amino Acids and Neuroprotection -- 8. Calcium Channel Blockers and Neuroprotection -- 9. Self-Defense of the Brain: Adenosinergic Strategies in Neurodegeneration -- 10. Gangliosides: New Generation of Neuroprotective Agents -- 11. Lazaroids: Novel Cerebroprotective Antioxidants -- 12. Membrane-Derived Lipid Second Messengers as Targets for Neuroprotection: Platelet-Activating Factor -- 13. Protection Against Oxidative Damage to CNS by ?-Phenyl-tert-butyl Nitrone and Other Spin-Trapping Agents: A Novel Series of Nonlipid Free Radical Scavengers -- 14. Insulin, Hypoglycemia, and Ischemic Neuroprotection -- 15. Temperature Modulation of Neuronal Injury -- 3. Clinical Endpoints for Neuroprotective Drugs -- 16. Clinical Trial Issues in Stroke Therapy -- 17. Excitotoxicity and Neurodegenerative Disorders.

The protective structures required for performing critical operations are vulnerable to the blast and shock loads of advanced weapons. A blast valve is an important component of such structures for ventilation during normal conditions and for protection from blast/ shock during explosion. In this paper, various aspects of blast valve design and related studies are briefly reviewed. The concept and effects of blast wave, blast impact, numerical modelling and deformation of circular plate (one of the critical components of blast valve) have been discussed. The merits and demerits of sensing mechanisms viz. remote and direct sensing are discussed. The leakage of blast pressure during finite closing period of the valve (one of the critical problems) and the shock tube as a major experimental facility for testing of blast valves are briefly discussed.