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Cover -- Title Page -- Copyright -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Lexington and Louisville -- 2. Cleveland -- 3. Alton -- Gallery of illustrations -- 4. Little Rock -- 5. Lake Village, Arkansas -- Conclusion -- Appendix: The Other Children -- Notes -- Bibliography -- Index -- About the Author -- Back Cover

"The fifth volume of The History of Evil covers the twentieth century from 1900-1950. The period saw the maturation of intellectual movements such as Pragmatism and Phenomenology, as well as the full emergence of several new academic disciplines; all these provided novel intellectual tools that were used to shed light on a human capacity for evil that was becoming increasingly hard to ignore. An underlying theme of the volume is the effort to reconstruct an understanding of human nature after confidence in its intrinsic goodness and moral character had been shaken by world events. The chapters in this volume cover globally relevant topics such as education, propaganda, power, oppression, and genocide, and include perspectives on evil drawn from across the world. Theological and atheistic responses to evil are examined in the volume. This outstanding treatment of approaches to evil at a determinative period of modernity will appeal to those with interests in the intellectual history of the era, as well as to those with interests in the political, philosophical and theological movements that matured within it.??"--Provided by publisher

Introduction: Atheisms and the power to be confrontedHarriet A. Harris1 A Quantum of Solace and a Heap of DoubtCarl Bråkenhielm2 Stepping Stone to Atheism?: The Instability of AgnosticismRobin le Poidevin3 A New Theist Meets Two AtheistsJeanine Diller4 Can an Atheist Display Religiously Significant AttitudesMax Baker-Hytch5 Doxastic and Nondoxastic AtheismsChristopher Jay6 Atheists and Idolaters: The Case of John Wren-Lewis (1923-2006)Stephen Clark7 How to Not think about GodMichael McGhee8 Atheist Aesthetics: A Critical ResponseDaniel Gustaffson9 Belief, Unbelief and MysteryKaren KilbyAppendix: Mapping Agnosticism: Comment inspired by Robin Le Poidevin's "Stepping Stone to Atheism? The Instability of Agnosticism"Jeanine Diller

This paper focuses on the process of self-transformation through which a person comes to embody the ideal of her religion's vision of the divine, as far as that ideal is expressible in a human life. The paper is concerned with the self as the subject of religious commitments, traits, religious aspirations and religiously inspired ideals. The self-transformative journey that people are invited to undertake poses a number of philosophical and practical difficulties; the paper explores some of these difficulties, concentrating on those that arise in connection with the notion of potential future selves. This paper suggests that imaginative reflection upon exemplary individuals provides one way through these difficulties, for these individuals can show us what it looks like when someone achieves, or draws close to, the ideal.

PurposePathogenic variants in SETD1B have been associated with a syndromic neurodevelopmental disorder including intellectual disability, language delay, and seizures. To date, clinical features have been described for 11 patients with (likely) pathogenic SETD1B sequence variants. This study aims to further delineate the spectrum of the SETD1B-related syndrome based on characterizing an expanded patient cohort.MethodsWe perform an in-depth clinical characterization of a cohort of 36 unpublished individuals with SETD1B sequence variants, describing their molecular and phenotypic spectrum. Selected variants were functionally tested using in vitro and genome-wide methylation assays.ResultsOur data present evidence for a loss-of-function mechanism of SETD1B variants, resulting in a core clinical phenotype of global developmental delay, language delay including regression, intellectual disability, autism and other behavioral issues, and variable epilepsy phenotypes. Developmental delay appeared to precede seizure onset, suggesting SETD1B dysfunction impacts physiological neurodevelopment even in the absence of epileptic activity. Males are significantly overrepresented and more severely affected, and we speculate that sex-linked traits could affect susceptibility to penetrance and the clinical spectrum of SETD1B variants.ConclusionInsights from this extensive cohort will facilitate the counseling regarding the molecular and phenotypic landscape of newly diagnosed patients with the SETD1B-related syndrome. ; We thank all patients and families for participation in this study. Part of this research was made possible through access to the data and findings generated by the 100,000 Genomes Project. The 100,000 Genomes Project is managed by Genomics England Limited (a wholly owned company of the Department of Health and Social Care). The 100,000 Genomes Project is funded by the National Institute for Health Research and NHS England. The Wellcome Trust, Cancer Research UK, and the Medical Research Council have also funded research infrastructure. The 100,000 Genomes Project uses data provided by patients and collected by the National Health Service as part of their care and support. Family 2 was collected as part of the SYNaPS Study Group collaboration funded by The Wellcome Trust and strategic award (Synaptopathies) funding (WT093205 MA and WT104033aIA) and research was conducted as part of the Queen Square Genomics group at University College London, supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. HH is funded by The MRC (MR/S01165X/1, MR/S005021/1, G0601943), The National Institute for Health Research University College London Hospitals Biomedical Research Centre, Rosetree Trust, Ataxia UK, MSA Trust, Brain Research UK, Sparks GOSH Charity, Muscular Dystrophy UK (MDUK), Muscular Dystrophy Association (MDA USA). G.M.M. was supported by Jordan's Guardian Angels, the Brotman Baty Institute, and the Sunderland Foundation. J.R.L. acknowledges support by the Baylor Hopkins Center for Mendelian Genomics funded by the US National Human Genome Research Institute (UM1 HG006542). The DECODE-EE project (Health Research Call 2018, Tuscany Region) provided research funding to R.G. The Epilepsy Society supported this work, with funding to S.M.S. S.M.S. acknowledges that his work was partly carried out at NIHR University College London Hospitals Biomedical Research Centre, which receives a proportion of funding from the UK Department of Health's NIHR Biomedical Research Centres funding scheme. A.J. is supported by Solve-RD. The Solve-RD project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement number 779257. STA, R.R., K.J.C.L., K.A.P.G., and F.J.G.V. were supported by funding from King Abdullah University of Science and Technology (KAUST) through the baseline fund and award numbers FCC/1/1976-25 and REI/1/4446-01 from the Office of Sponsored Research (OSR). T.S.B.'s lab is supported by the Netherlands Organisation for Scientific Research (ZonMW Veni, grant 91617021), a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation, an Erasmus MC Fellowship 2017, and Erasmus MC Human Disease Model Award 2018.