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Vitamin D is mainly obtained through sunlight ultraviolet-B (UVB) exposure of the skin, with a small amount typically coming from the diet.It is now clear that vitamin D has important roles beyond its well-known effects on calcium and bone homeostasis. Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D 75 nmol/L.

This article was published in the journal Exercise Immunology Review and is available here with the kind permission of the publisher. ; Vitamin D is mainly obtained through sunlight ultraviolet-B (UVB) exposure of the skin, with a small amount typically coming from the diet. It is now clear that Vitamin D has important roles beyond its well-known effects on calcium and bone homeostasis. Immune cells express the Vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active Vitamin D metabolite, 1, 25 dihydroxy Vitamin D. There has been growing interest in the benefits of supplementing Vitamin D as studies report Vitamin D insufficiency (circulating 25(OH)D 75 nmol/L.