Suchergebnisse

Foreign language classroom anxiety (FLCA) is a very critical affective factor for learners' language learning and development. The present study was designed to explore the features of Chinese university students' FLCA and to investigate the possible influencing factors on the fluctuations of Chinese university students' FLCA. Two female and two male Chinese university students were selected as the participants and their in-class performances were recorded. Data collection instrument included the classroom observation, the self-rated evaluation of FLCA, and the stimulated recall interview. To capture the micro-changes of the Chinese learners' FLCA per second, an idiodynamic approach was adopted to carry out the exploratory analysis for the learners' experiences of FLCA over the language instruction. Zooming in on the microdynamic variation of the participants' FLCA, the final results indicated that Chinese university students' FLCA, both within individuals and across individuals, is characterized of a dynamic system's features. Furthermore, a series of contributing factors were identified to trigger the participants' FLCA, with the classroom activity types and the teacher's feedback being the key external factors and the gender difference and self-efficacy being the major internal factors. The idiodynamic method shed new light on exploring the FLCA from an emic and dynamic perspective and some pedagogical implications were also put forward as well.

The environmental situation is not optimistic. Improving the level of enterprise green development behavior can help enterprises to comply with the trend of environmental protection. However, existing studies do not explain the factors influencing enterprise green development behavior. This research collects and screens 33 empirical studies related to enterprise green development behavior from multiple authoritative data platforms, which cover 10 different countries and regions. A quantitative approach is then used to comprehensively explore the influencing factors, deeply dig into their degree of influence, and explore the moderating effect of the moderators. The results show the following: (1) corporate tangible resources, corporate intangible resources, market environment, policy and institutional environment, and public supervision have positive effects on enterprise green development behavior, and there are differences in the degree of influence; (2) corporate intangible resources have the most significant influence on enterprise green development behavior; (3) the size, region, and industry of enterprise can moderate enterprise green development behavior. This research suggests four participants: society, enterprise, market, and government. The research results are intended to provide a basis for researchers to further study enterprise green development behavior for specific industries and promote enterprise green development.

Cong Zhou,1 Xiang He,1,2,* Qi Zeng,3 Peng Zhang,4 Chun-ting Wang5,* 1Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China; 2Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, People's Republic of China; 3Second Affiliated Hospital, Army Military Medical University, Chongqing 400037, People's Republic of China; 4Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu 610041, People's Republic of China; 5State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China*These authors contributed equally to this workCorrespondence: Xiang HeDepartment of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, 610041, P. R. China, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, No. 20, Section 3, People's Road, Chengdu, Sichuan Province 610041, People's Republic of ChinaTel +86-18180609069Fax +86-28-85559065Email popxiang@163.comChun-ting WangState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan Province 610041, People's Republic of ChinaTel +86-28-85164063Fax +86-28-85164060Email chtwang@scu.edu.cnObjective: Tumor growth is one of the most lethal attributes of human malignancy. The expression of CCDC7, a novel gene which has multiple functions, has been shown to be associated with tumor growth and poor prognosis in patients with cancer. However, the specific functions of CCDC7 remain unclear. Here, we investigated the molecular mechanisms underlying the effects of CCDC7 on proliferation in cervical cancer.Materials and Methods: The MTT and EdU assays were performed to evaluate the function of CCDC7. The immunohistochemical, quantitative real-time PCR (qRT-PCR), ELISA and Western blot assay were used to detect the gene and protein expression in tissues and cells. A xenograft test was conducted to detect the impact of CCDC7 on tumor development in vivo.Results: In immunohistochemical analysis of 193 cases, normal cervical tissue and cervical cancer tissue show that CCDC7 expression is closely correlated with the development of cervical cancer and was positively correlated with the clinical stage and histological grade. Overexpression or knockdown of CCDC7 affected cell proliferation in cervical cancer cells in vitro. In a nude mouse xenograft model in vivo, knockdown of CCDC7 inhibited cell proliferation and tumor growth. Furthermore, CCDC7 overexpression upregulated interleukin (IL)-6 and vascular endothelial growth factor (VEGF) at mRNA and protein levels, and treatment with recombinant IL-6 or VEGF proteins also increased CCDC7 expression. In a case set of 80 patients with cervical cancer, we found that CCDC7, IL-6, and VEGF affected patient prognosis. Finally, inhibition of various signaling pathways using specific inhibitors indicated that CCDC7 blocked the decrease in cell proliferation observed following suppression of the JAK-STAT3 pathway, suggesting that CCDC7 functioned via this critical signaling network.Conclusion: Those findings indicated that CCDC7 may be a novel target for the treatment of cervical cancer and may have applications as a predictive marker for tumor growth in cervical carcinoma.Keywords: CCDC7, IL-6, VEGF, tumor growth, cervical cancer, gene therapy