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In vitro biotransformation of pharmaceuticals and pesticides by trout liver S9 in the presence and absence of carbamazepine
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 183, S. 109513
ISSN: 1090-2414
Response to comment of Sierra Rayne on "Targeting aquatic microcontaminants for monitoring: exposure categorization and application to the Swiss situation [Götz et al., Environ Sci Pollut Res (2010) 17:341–354]"
In: Environmental science and pollution research: ESPR, Band 20, Heft 9, S. 6678-6680
ISSN: 1614-7499
Elucidating the spatial distribution of organic contaminants and their biotransformation products in amphipod tissue by MALDI- and DESI-MS-imaging
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 264, S. 115468
ISSN: 1090-2414
Characterization of acetylcholinesterase inhibition and energy allocation in Daphnia magna exposed to carbaryl
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 98, S. 28-35
ISSN: 1090-2414
Ecotoxicity of quinoline and hydroxylated derivatives and their occurrence in groundwater of a tar-contaminated field site
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 72, Heft 3, S. 819-827
ISSN: 1090-2414
Establish data infrastructure to compile and exchange environmental screening data on a European scale
In: Environmental sciences Europe: ESEU, Band 31, Heft 1
ISSN: 2190-4715
Abstract
Robust techniques based on liquid (LC) and gas chromatography (GC) coupled with high-resolution mass spectrometry (HR-MS) enable sensitive screening, identification, and (semi)quantification of thousands of substances in a single sample. Recent progress in computational sciences has enabled archiving and processing of HR-MS 'big data' at the routine level. As a result, community-based databases containing thousands of environmental pollutants are rapidly growing and large databases of substances with unique identifiers allowing for inter-comparison at the global scale have become available. A data-archiving infrastructure is proposed, allowing for retrospective screening of HR-MS data, which will help define the 'chemical universe' of organic substances and enable prioritisation of toxicants causing adverse environmental effects at the local, river basin, and national and European scale in support of the European water and chemicals management policy.
Removal of highly polar micropollutants from wastewater by powdered activated carbon
In: Environmental science and pollution research: ESPR, Band 20, Heft 6, S. 3607-3615
ISSN: 1614-7499
Targeting aquatic microcontaminants for monitoring: exposure categorization and application to the Swiss situation
In: Environmental science and pollution research: ESPR, Band 17, Heft 2, S. 341-354
ISSN: 1614-7499
Erfolgreiche Zweite Gemeinsame Jahrestagung von SETAC-GLB und GDCh-Fachgruppe 'Umweltchemie und Ökotoxikologie' unter dem Motto 'Grenzen finden, Grenzen überwinden-Molekulare Mechanismen und ökosystemare Prozesse' am 06.–08. Oktober 2004 in Aachen
In: Umweltwissenschaften und Schadstoff-Forschung: UWSF ; Zeitschrift für Umweltchemie und Ökotoxikologie ; Organ des Verbandes für Geoökologie in Deutschland (VGöD) und der Eco-Informa, Band 16, Heft 4, S. 281-282
ISSN: 1865-5084
Chlorothalonil transformation products in drinking water resources: Widespread and challenging to abate
© 2020 The Authors Chlorothalonil, a fungicide applied for decades worldwide, has recently been banned in the European Union (EU) and Switzerland due to its carcinogenicity and the presence of potentially toxic transformation products (TPs) in groundwater. The spread and concentration range of chlorothalonil TPs in different drinking water resources was examined (73 groundwater and four surface water samples mainly from Switzerland). The chlorothalonil sulfonic acid TPs (R471811, R419492, R417888) occurred more frequently and at higher concentrations (detected in 65–100% of the samples, ≤2200 ngL−1) than the phenolic TPs (SYN507900, SYN548580, R611968; detected in 10–30% of the samples, ≤130 ngL−1). The TP R471811 was found in all samples and even in 52% of the samples above 100 ngL−1, the drinking water standard in Switzerland and other European countries. Therefore, the abatement of chlorothalonil TPs was investigated in laboratory and pilot-scale experiments and along the treatment train of various water works, comprising aquifer recharge, UV disinfection, ozonation, advanced oxidation processes (AOPs), activated carbon treatment, and reverse osmosis. The phenolic TPs can be abated during ozonation (second order rate constant kO3 ∼104 M−1s−1) and by reaction with hydroxyl radicals ([rad]OH) in AOPs (kOH ∼109 M−1s−1). In contrast, the sulfonic acid TPs, which occurred in higher concentrations in drinking water resources, react only very slowly with ozone (kO3 <0.04 M−1s−1) and [rad]OH (kOH <5.0 × 107 M−1s−1) and therefore persist in ozonation and [rad]OH-based AOPs. Activated carbon retained the very polar TP R471811 only up to a specific throughput of 25 m3kg-1 (20% breakthrough), similarly to the X-ray contrast agent diatrizoic acid. Reverse osmosis was capable of removing all chlorothalonil TPs by ≥98%. ; ISSN:0043-1354 ; ISSN:1879-2448
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High-resolution mass spectrometry to complement monitoring and track emerging chemicals and pollution trends in European water resources
Currently, chemical monitoring based on priority substances fails to consider the majority of known environmental micropollutants not to mention the unexpected and unknown chemicals that may contribute to the toxic risk of complex mixtures present in the environment. Complementing component- and effect-based monitoring with wide-scope target, suspect, and non-target screening (NTS) based on high-resolution mass spectrometry (HRMS) data is recommended to support environmental impact and risk assessment. This will allow for detection of newly emerging compounds and transformation products, retrospective monitoring efforts, and the identification of possible drivers of toxicity by correlation with effects or modelling of expected effects for future and abatement scenarios. HRMS is becoming increasingly available in many laboratories. Thus, the time is right to establish and harmonize screening methods, train staff, and record HRMS data for samples from regular monitoring events and surveys. This will strongly enhance the value of chemical monitoring data for evaluating complex chemical pollution problems, at limited additional costs. Collaboration and data exchange on a European-to-global scale is essential to maximize the benefit of chemical screening. Freely accessible data platforms, inter-laboratory trials, and the involvement of international partners and networks are recommended. © 2019, The Author(s). ; This article has been prepared as an outcome of the SOLUTIONS project (European Union's Seventh Framework Programme for research, technological development and demonstration under Grant Agreement No. 603437). ; Peer reviewed
BASE
High-resolution mass spectrometry to complement monitoring and track emerging chemicals and pollution trends in European water resources
In: Environmental sciences Europe: ESEU, Band 31, Heft 1
ISSN: 2190-4715
Abstract
Currently, chemical monitoring based on priority substances fails to consider the majority of known environmental micropollutants not to mention the unexpected and unknown chemicals that may contribute to the toxic risk of complex mixtures present in the environment. Complementing component- and effect-based monitoring with wide-scope target, suspect, and non-target screening (NTS) based on high-resolution mass spectrometry (HRMS) data is recommended to support environmental impact and risk assessment. This will allow for detection of newly emerging compounds and transformation products, retrospective monitoring efforts, and the identification of possible drivers of toxicity by correlation with effects or modelling of expected effects for future and abatement scenarios. HRMS is becoming increasingly available in many laboratories. Thus, the time is right to establish and harmonize screening methods, train staff, and record HRMS data for samples from regular monitoring events and surveys. This will strongly enhance the value of chemical monitoring data for evaluating complex chemical pollution problems, at limited additional costs. Collaboration and data exchange on a European-to-global scale is essential to maximize the benefit of chemical screening. Freely accessible data platforms, inter-laboratory trials, and the involvement of international partners and networks are recommended.
Wide-scope target screening of >2000 emerging contaminants in wastewater samples with UPLC-Q-ToF-HRMS/MS and smart evaluation of its performance through the validation of 195 selected representative analytes
This study presents the development and validation of a comprehensive quantitative target methodology for the analysis of 2316 emerging pollutants in water based on Ultra-Performance Liquid Chromatography Quadrupole-Time-Of-Flight Mass Spectrometry (UPLC-Q-ToF-HRMS/MS). Target compounds include pesticides, pharmaceuticals, drugs of abuse, industrial chemicals, doping compounds, surfactants and transformation products, among others. The method was validated for 195 analytes, chosen to be representative of the chemical space of the target list, enabling the assessment of the performance of the method. The method involves a generic sample preparation based on mixed mode solid phase extraction, a UPLC-QTOF-MS/MS screening method using Data Independent Acquisition (DIA) mode, which provides MS and MS/MS spectra simultaneously and an elaborate strong post-acquisition evaluation of the data. The processing method was optimized to provide a successful identification rate >95 % and to minimize the number of false positive results (< 5 %). Decision limit (CCα) and detection capability (CCβ) were also introduced in the validation scheme to provide more realistic metrics on the performance of a HRMS-based wide-scope screening method. A new system of identification points (IPs) based on the one described in the Commission Decision 2002/657/EC was applied to communicate the confidence level in the identification of the analytes. This system considers retention time, mass accuracy, isotopic fit and fragmentation; taking full advantage of the capacities of the HRMS instruments. Finally, 398 contaminants were detected and quantified in real wastewater ; This project was implemented under the Operational Program "Education and Lifelong Learning" and funded by the European Union (European Social Fund) and Greek National Resources – ARISTEIA 624 (TREMEPOL project). Pablo Gago-Ferrero acknowledges the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement Smart-Workflow ...
BASE
Emerging pollutants in the EU: 10 years of NORMAN in support of environmental policies and regulations
In: Environmental sciences Europe: ESEU, Band 30, Heft 1
ISSN: 2190-4715