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Babies born during the pandemic are behind on communication at age two—but other developmental areas remain unaffected.

The Gaia-ESO Survey (GES) observed many open clusters as part of its programme to spectroscopically characterize the various Milky Way populations. GES spectroscopy and Gaia astrometry from its second data release are used here to assign membership probabilities to targets towards 32 open clusters with ages from 1 to 3800 Myr, based on maximum likelihood modelling of the 3D kinematics of the cluster and field populations. From a parent catalogue of 14 398 individual targets, 5032 stars with uniformly determined 3D velocities, Teff, log g, and chemistry are assigned cluster membership with probability >0.9, and with an average probability of 0.991. The robustness of the membership probabilities is demonstrated using independent membership criteria (lithium and parallax) in two of the youngest clusters. The addition of radial velocities improves membership discrimination over proper motion selection alone, especially in more distant clusters. The kinematically selected nature of the membership lists, independent of photometry and chemistry, makes the catalogue a valuable resource for testing stellar evolutionary models and investigating the time evolution of various parameters. ; This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant no. RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Università' e della Ricerca (MIUR) in the form of the grant 'Premiale VLT 2012'. The results presented here benefit from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. ; Peer reviewed

The combination of precise radial velocities from multi-object spectroscopy and highly accurate proper motions from Gaia DR2 opens up the possibility for detailed 3D kinematic studies of young star-forming regions and clusters. Here, we perform such an analysis by combining Gaia-ESO Survey spectroscopy with Gaia astrometry for ∼900 members of the Lagoon Nebula cluster, NGC 6530. We measure the 3D velocity dispersion of the region to be 5.35+0.39 -0.34 km s, which is large enough to suggest the region is gravitationally unbound. The velocity ellipsoid is anisotropic, implying that the region is not sufficiently dynamically evolved to achieve isotropy, though the central part of NGC 6530 does exhibit velocity isotropy that suggests sufficient mixing has occurred in this denser part. We find strong evidence that the stellar population is expanding, though this is preferentially occurring in the declination direction and there is very little evidence for expansion in the right ascension direction. This argues against a simple radial expansion pattern, as predicted by models of residual gas expulsion. We discuss these findings in the context of cluster formation, evolution, and disruption theories.© 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society. ; NJW acknowledges an STFC Ernest Rutherford Fellowship (grant number ST/M005569/1). RJP acknowledges support from the Royal Society in the form of a Dorothy Hodgkin Fellowship. AB acknowledges support from ICM (Iniciativa Cientifica Milenio) via the Nucleo Milenio de Formacion Planetaria. EJA acknowledges support from the Spanish Government Ministerio de Ciencia, Innovacion y Universidades though grant AYA2016-75 931-C2-1 and from the State Agency for Research of the Spanish MCIU through the 'Center of Excellence Severo Ochoa' award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709). ; Peer Reviewed

Regional and national legislation mandates the disclosure of "priority" allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen ("may contain") labels (PAL) which are frequently ignored by food allergic consumers. Attempts have been made to improve allergen risk management to better inform the use of PAL, but a lack of consensus has led to variety of regulatory approaches and non-uniformity in the use of PAL by food businesses. One potential solution would be to establish internationally-agreed "reference doses", below which no PAL would be needed. However, if reference doses are to be used to inform the need for PAL, then it is essential to characterize the hazard associated with these low-level exposures. For peanut, there are now published data relating to over 3000 double-blind, placebo-controlled challenges in allergic individuals, but a similar level of evidence is lacking for other priority allergens. We present the results of a rapid evidence assessment and meta-analysis for the risk of anaphylaxis to low-level allergen exposure for priority allergens. On the basis of this analysis, we propose that peanut can and should be considered an exemplar allergen for the hazard characterization at low-level allergen exposure.

Context. There have been conflicting results with respect to the extent that radial migration has played in the evolution of the Galaxy. Additionally, observations of the solar neighborhood have shown evidence of a merger in the past history of the Milky Way that drives enhanced radial migration. Aims. We attempt to determine the relative fraction of stars that have undergone significant radial migration by studying the orbital properties of metal-rich ([Fe/H] > 0.1) stars within 2 kpc of the Sun. We also aim to investigate the kinematic properties, such as velocity dispersion and orbital parameters, of stellar populations near the Sun as a function of [Mg/Fe] and [Fe/H], which could show evidence of a major merger in the past history of the Milky Way. Methods. We used a sample of more than 3000 stars selected from the fourth internal data release of the Gaia-ESO Survey. We used the stellar parameters from the Gaia-ESO Survey along with proper motions from PPMXL to determine distances, kinematics, and orbital properties for these stars to analyze the chemodynamic properties of stellar populations near the Sun. Results. Analyzing the kinematics of the most metal-rich stars ([Fe/H] > 0.1), we find that more than half have small eccentricities (e 7 kpc. We find that the highest [Mg/Fe], metal-poor populations have lower vertical and radial velocity dispersions compared to lower [Mg/Fe] populations of similar metallicity by ~10 km s. The median eccentricity increases linearly with [Mg/Fe] across all metallicities, while the perigalacticon decreases with increasing [Mg/Fe] for all metallicities. Finally, the most [Mg/Fe]-rich stars are found to have significant asymmetric drift and rotate more than 40 km s slower than stars with lower [Mg/Fe] ratios. Conclusions. While our results cannot constrain how far stars have migrated, we propose that migration processes are likely to have played an important role in the evolution of the Milky Way, with metal-rich stars migrating from the inner disk toward to solar neighborhood and past mergers potentially driving enhanced migration of older stellar populations in the disk.© ESO, 2018. ; The authors thank Ivan Minchev for a useful discussion and the anonymous referee for useful comments. M.R.H. and A.R.B. received financial support from ANR, reference 14-CE33-0014-01. S.F. and T.B. acknowledge support from the project grant >The New Milky Way> from the Knut and Alice Wallenberg Foundation. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under program ID 188.B-3002. These data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. These data have been obtained from the Gaia-ESO Survey Data Archive, prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council. This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Universita' e della Ricerca (MIUR) in the form of the grant >Premiale VLT 2012>. The results presented here benefit from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. This research has made use of the SIMBAD database, operated at CDS, Strasbourg, France and NASA's Astrophysics Data System.

Aims. We present observations from the Gaia-ESO Survey in the lines of Hα, [N II], [S II], and He I of nebular emission in the central part of the Carina nebula. Methods. We investigate the properties of the two already known kinematic components (approaching and receding), which account for the bulk of emission. Moreover, we investigate the features of the much less known low-intensity high-velocity (absolute RV >50 km s-1) gas emission. Results. We show that gas giving rise to Hα and He I emission is dynamically well correlated with but not identical to gas seen through forbidden-line emission. Gas temperatures are derived from line-width ratios, and densities from [S II] doublet ratios. The spatial variation of N ionization is also studied, and found to differ between the approaching and receding components. The main result is that the bulk of the emission lines in the central part of Carina arise from several distinct shell-like expanding regions, the most evident found around η Car, the Trumpler 14 core, and the star WR25. These "shells" are non-spherical and show distortions probably caused by collisions with other shells or colder, higher-density gas. Some of them are also partially obscured by foreground dust lanes, while very little dust is found in their interior. Preferential directions, parallel to the dark dust lanes, are found in the shell geometries and physical properties, probably related to strong density gradients in the studied region. We also find evidence that the ionizing flux emerging from η Car and the surrounding Homunculus nebula varies with polar angle. The high-velocity components in the wings of Hα are found to arise from expanding dust reflecting the η Car spectrum. ; This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541.

Context. In very young clusters, stellar age distribution is empirical proof of the duration of star cluster formation and thus it gives indications of the physical mechanisms involved in the star formation process. Determining the amount of interstellar extinction and the correct reddening law are crucial steps to derive fundamental stellar parameters and in particular accurate ages from the Hertzsprung-Russell diagram. Aims. In this context, we seek to derive accurate stellar ages for NGC 6530, the young cluster associated with the Lagoon Nebula to infer the star formation history of this region. Methods. We used the Gaia-ESO survey observations of the Lagoon Nebula, together with photometric literature data and Gaia DR2 kinematics, to derive cluster membership and fundamental stellar parameters. Using spectroscopic effective temperatures, we analysed the reddening properties of all objects and derived accurate stellar ages for cluster members. Results. We identified 652 confirmed and 9 probable members. The reddening inferred for members and non-members allows us to distinguish foreground objects, mainly main-sequence stars, and background objects, mainly giants, and to trace the three-dimensional structure of the nebula. This classification is in agreement with the distances inferred from Gaia DR2 parallaxes for these objects. Finally, we derive stellar ages for 382 confirmed cluster members for which we obtained the individual reddening values. In addition, we find that the gravity-sensitive γ index distribution for the M-type stars is correlated with stellar age. Conclusions. For all members with Teff The Gaia-ESO Survey>, P.I.: S. Randich). This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. ; Peer Reviewed

Aims: We present the first extensive spectroscopic study of the global population in star clusters Trumpler 16, Trumpler 14, and Collinder 232 in the Carina nebula, using data from the Gaia-ESO Survey, down to solar-mass stars. Methods: In addition to the standard homogeneous survey data reduction, a special processing was applied here because of the bright nebulosity surrounding Carina stars. Results: We find about 400 good candidate members ranging from OB types down to slightly subsolar masses. About 100 heavily reddened early-type Carina members found here were previously unrecognized or poorly classified, including two candidate O stars and several candidate Herbig Ae/Be stars. Their large brightness makes them useful tracers of the obscured Carina population. The spectroscopically derived temperatures for nearly 300 low-mass members enables the inference of individual extinction values and the study of the relative placement of stars along the line of sight. Conclusions: We find a complex spatial structure with definite clustering of low-mass members around the most massive stars and spatially variable extinction. By combining the new data with existing X-ray data, we obtain a more complete picture of the three-dimensional spatial structure of the Carina clusters and of their connection to bright and dark nebulosity and UV sources. The identification of tens of background giants also enables us to determine the total optical depth of the Carina nebula along many sightlines. We are also able to put constraints on the star formation history of the region with Trumpler 14 stars found to be systematically younger than stars in other subclusters. We find a large percentage of fast-rotating stars among Carina solar-mass members, which provide new constraints on the rotational evolution of pre-main-sequence stars in this mass range.© 2017 ESO. ; This work was partly supported by the European Union FP7 program through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. ; Peer Reviewed

Context. Open clusters are recognised as excellent tracers of Galactic thin-disc properties. At variance with intermediate-age and old open clusters, for which a significant number of studies is now available, clusters younger than ≲ 150 Myr have been mostly overlooked in terms of their chemical composition until recently (with few exceptions). On the other hand, previous investigations seem to indicate an anomalous behaviour of young clusters, which includes (but is not limited to) slightly sub-solar iron (Fe) abundances and extreme, unexpectedly high barium (Ba) enhancements. Aims. In a series of papers, we plan to expand our understanding of this topic and investigate whether these chemical peculiarities are instead related to abundance analysis techniques. Methods. We present a new determination of the atmospheric parameters for 23 dwarf stars observed by the Gaia-ESO survey in five young open clusters (τ < 150 Myr) and one star-forming region (NGC 2264). We exploit a new method based on titanium (Ti) lines to derive the spectroscopic surface gravity, and most importantly, the microturbulence parameter. A combination of Ti and Fe lines is used to obtain effective temperatures. We also infer the abundances of Fe » I, Fe » II, Ti » I, Ti » II, Na » I, Mg » I, Al » I, Si » I, Ca » I, Cr » I, and Ni » I. Results. Our findings are in fair agreement with Gaia-ESO iDR5 results for effective temperatures and surface gravities, but suggest that for very young stars, the microturbulence parameter is over-estimated when Fe lines are employed. This affects the derived chemical composition and causes the metal content of very young clusters to be under-estimated. Conclusions. Our clusters display a metallicity [Fe/H] between +0.04 ± 0.01 and +0.12 ± 0.02; they are not more metal poor than the Sun. Although based on a relatively small sample size, our explorative study suggests that we may not need to call for ad hoc explanations to reconcile the chemical composition of young open clusters with Galactic chemical evolution models. ; With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)

Regional and national legislation mandates the disclosure of "priority" allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen ("may contain") labels (PAL) that are frequently ignored by food-allergic consumers. Attempts have been made to improve allergen risk management to better inform the use of PAL, but a lack of consensus has led to variety of regulatory approaches and nonuniformity in the use of PAL by food businesses. One potential solution would be to establish internationally agreed "reference doses," below which no PAL would be needed. However, if reference doses are to be used to inform the need for PAL, then it is essential to characterize the hazard associated with these low-level exposures. For peanut, there are now published data relating to over 3000 double-blind, placebo-controlled challenges in allergic individuals, but a similar level of evidence is lacking for other priority allergens. We present the results of a rapid evidence assessment and meta-analysis for the risk of anaphylaxis to a low-level allergen exposure for priority allergens. On the basis of this analysis, we propose that peanut can and should be considered an exemplar allergen for the hazard characterization at a low-level allergen exposure.

Context. Open clusters are recognised as excellent tracers of Galactic thin-disc properties. At variance with intermediate-age and old open clusters, for which a significant number of studies is now available, clusters younger than ≲ 150 Myr have been mostly overlooked in terms of their chemical composition until recently (with few exceptions). On the other hand, previous investigations seem to indicate an anomalous behaviour of young clusters, which includes (but is not limited to) slightly sub-solar iron (Fe) abundances and extreme, unexpectedly high barium (Ba) enhancements. Aims. In a series of papers, we plan to expand our understanding of this topic and investigate whether these chemical peculiarities are instead related to abundance analysis techniques. Methods. We present a new determination of the atmospheric parameters for 23 dwarf stars observed by the Gaia-ESO survey in five young open clusters (τ < 150 Myr) and one star-forming region (NGC 2264). We exploit a new method based on titanium (Ti) lines to derive the spectroscopic surface gravity, and most importantly, the microturbulence parameter. A combination of Ti and Fe lines is used to obtain effective temperatures. We also infer the abundances of Fe » I, Fe » II, Ti » I, Ti » II, Na » I, Mg » I, Al » I, Si » I, Ca » I, Cr » I, and Ni » I. Results. Our findings are in fair agreement with Gaia-ESO iDR5 results for effective temperatures and surface gravities, but suggest that for very young stars, the microturbulence parameter is over-estimated when Fe lines are employed. This affects the derived chemical composition and causes the metal content of very young clusters to be under-estimated. Conclusions. Our clusters display a metallicity [Fe/H] between +0.04 ± 0.01 and +0.12 ± 0.02; they are not more metal poor than the Sun. Although based on a relatively small sample size, our explorative study suggests that we may not need to call for ad hoc explanations to reconcile the chemical composition of young open clusters with Galactic chemical evolution models. © ESO 2020. ; This work is based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002. These data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. These data have been obtained from the Gaia-ESO Survey Data Archive, prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council. This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Universita' e della Ricerca (MIUR) in the form of the grant "Premiale VLT 2012". The results presented here benefit from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. V.A. is supported by FCT -Fundacao para a Ciencia e a Tecnologia through national funds and by FEDER through COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao by these grants: Investigador FCT contract nr. IF/00650/2015/CP1273/CT0001; UID/FIS/04434/2019; PTDC/FIS-AST/28953/2017 & POCI-01-0145-FEDER-028953 and PTDC/FIS-AST/32113/2017 & POCI-01-0145-FEDER-032113. F.J.E. acknowledges financial support from the Spanish MINECO/FEDER through grant AyA2017-84089. T.B. was supported by the project grant "The New Milky Way" from the Knut and Alice Wallenberg Foundation. U.H. acknowledges support from the Swedish National Space Agency (SNSA/Rymdstyrelsen). S.G.S acknowledges the support by Fundacao para a Ciencia e Tecnologia (FCT) through national funds and a research grant (project ref. UID/FIS/04434/2013, and PTDC/FIS-AST/7073/2014). S.G.S. also acknowledge the support from FCT through Investigador FCT contract of reference IF/00028/2014 and POPH/FSE (EC) by FEDER funding through the program -Programa Operacional de Factores de Competitividade -COMPETE. ; Peer reviewed

Context. In the era of large spectroscopic surveys, massive databases of high-quality spectra coupled with the products of the Gaia satellite provide tools to outline a new picture of our Galaxy. In this framework, an important piece of information is provided by our ability to infer stellar ages, and consequently to sketch a Galactic timeline. Aims. We aim to provide empirical relations between stellar ages and abundance ratios for a sample of stars with very similar stellar parameters to those of the Sun, namely the so-called solar-like stars. We investigate the dependence on metallicity, and we apply our relations to independent samples, that is, the Gaia-ESO samples of open clusters and of field stars. Methods. We analyse high-resolution and high-signal-to-noise-ratio HARPS spectra of a sample of solar-like stars to obtain precise determinations of their atmospheric parameters and abundances for 25 elements and/or ions belonging to the main nucleosynthesis channels through differential spectral analysis, and of their ages through isochrone fitting. Results. We investigate the relations between stellar ages and several abundance ratios. For the abundance ratios with a steeper dependence on age, we perform multivariate linear regressions, in which we include the dependence on metallicity, [Fe/H]. We apply our best relations to a sample of open clusters located from the inner to the outer regions of the Galactic disc. Using our relations, we are able to recover the literature ages only for clusters located at RGC&Rlarr2; > &Rlarr2; 7 kpc. The values that we obtain for the ages of the inner-disc clusters are much greater than the literature ones. In these clusters, the content of neutron capture elements, such as Y and Zr, is indeed lower than expected from chemical evolution models, and consequently their [Y/Mg] and [Y/Al] are lower than in clusters of the same age located in the solar neighbourhood. With our chemical evolution model and a set of empirical yields, we suggest that a strong dependence on the star formation history and metallicity-dependent stellar yields of s-process elements can substantially modify the slope of the [s/α]-[Fe/H]-age relation in different regions of the Galaxy. Conclusions. Our results point towards a non-universal relation [s/α]-[Fe/H]-age, indicating the existence of relations with different slopes and intercepts at different Galactocentric distances or for different star formation histories. Therefore, relations between ages and abundance ratios obtained from samples of stars located in a limited region of the Galaxy cannot be translated into general relations valid for the whole disc. A better understanding of the s-process at high metallicity is necessary to fully understand the origin of these variations. © ESO 2020. ; The authors would like to thanks Dr. Leslie K. Hunt for her help in the statistical interpretation of our results. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002. These data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. These data have been obtained from the GES Survey Data Archive, prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council (STFC). This research has made use of the services of the ESO Science Archive Facility. This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Universita e della Ricerca (MIUR) in the form of the grant "Premiale VLT 2012". The results presented here benefit from discussions held during the GES workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. LM acknowledge the funding from the INAF PRIN-SKA 2017 program 1.05.01.88.04. LM and MVdS acknowledge the funding from MIUR Premiale 2016: MITIC. T.B. was supported by the project grant "The New Milky Way" from the Knut and Alice Wallenberg Foundation. M. acknowledges support provided by the Spanish Ministry of Economy and Competitiveness (MINECO), under grant AYA-2017-88254-P. L.S. acknowledges financial support from the Australian Research Council (Discovery Project 170100521) and from the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013. F.J.E. acknowledges financial support from the ASTERICS project (ID:653477, H2020-EU.1.4.1.1. - Developing new world-class research infrastructures). U.H. acknowledges support from the Swedish National Space Agency (SNSA/Rymdstyrelsen). T.B was partly funded by the project grant "The New Milky Way" from the Knut and Alice Wallenberg Foundation, and partly by grant No. 2018-04857 from the Swedish Research Council. ; Peer reviewed

Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate variations in the surface chemical composition of member stars of the old open clusterM67 as a possible consequence of atomic diffusion effects taking place during the main-sequence phase. The abundances used are obtained from high-resolution UVES/FLAMES spectra within the framework of the Gaia-ESO Survey. We find that the surface abundances of stars on the main sequence decrease with increasing mass reaching a minimum at the turn-off. After deepening of the convective envelope in subgiant branch stars, the initial surface abundances are restored.We found themeasured abundances to be consistent with the predictions of stellar evolutionary models for a cluster with the age and metallicity of M67. Our findings indicate that atomic diffusion poses a non-negligible constraint on the achievable precision of chemical tagging methods.© 2018 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society. ; This work was supported by Sonderforschungsbereich SFB 881 'The Milky Way System' (subproject B5) of the German Research Foundation (DFG). AB acknowledges support from the SFB 881 visitor program. CBM thanks Elisabetta Caffau for fruitful discussions and Don VandenBerg for providing the isochrones shown in Fig 1. The authors would like to thank the anonymous referee for the constructive comments that helped in improving the present work.r MTC acknowledges the financial support from the Spanish Ministerio de Economia y Competitividad, through grant AYA2016-75931. AD and GT acknowledge support by the Research Council of Lithuania (MIP-082/2015). UH acknowledges support from the Swedish National Space Board (SNSB/Rymdstyrelsen). TB was supported by the project grant 'The New Milky' from the Knut and Alice Wallenberg foundation. RS acknowledges support from the Polish Ministry of Science and Higher Education. SGS and VA acknowledge the support by Fundacao para a Ciencia e Tecnologia (FCT) through national funds and a research grant (project ref. UID/FIS/04434/2013, and PTDC/FISAST/7073/2014). SGS also acknowledges the support from FCT through Investigador FCT contract of reference IF/00028/2014 and POPH/FSE (EC) by FEDER funding through the program 'Programa Operacional de Factores de Competitividade - COMPETE'. VA acknowledges the support from FCT through Investigador FCT contract IF/00650/2015/CP1273/CT0001. EJA acknowledges partial support from the Spanish Ministry for Economy and Competitiveness and FEDER funds through grant AYA2013-40611-P. ARC is supported through an Australian Research Council Discovery Project under grant DP160100637. CL thanks the Swiss National Science Foundation for supporting this research through the Ambizione grant number PZ00P2 168065. AK acknowledges support from the Swedish National Space Board (SNSB). XF acknowledges financial support from Premiale 2015 MITiC (PI B/Garilli). SLM acknowledges support from the Australian Research Council through grant DE140100598. AB acknowledges support from the Millennium Science Initiative (Chilean Ministry of Economy).r Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002. These data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. These data have been obtained from the Gaia-ESO Survey Data Archive, prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council. This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Universita' e della Ricerca (MIUR) in the form of the grant 'Premiale VLT 2012', and through PRIN-INAF 2014 'The Gaia-ESO Survey'. The results presented here benefit from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. This research has made use of the SIMBAD data base, operated at CDS, Strasbourg, France and NASA's Astrophysics Data System.

Regional and national legislation mandates the disclosure of "priority" allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen ("may contain") labels (PAL) that are frequently ignored by food-allergic consumers. Attempts have been made to improve allergen risk management to better inform the use of PAL, but a lack of consensus has led to variety of regulatory approaches and nonuniformity in the use of PAL by food businesses. One potential solution would be to establish internationally agreed "reference doses," below which no PAL would be needed. However, if reference doses are to be used to inform the need for PAL, then it is essential to characterize the hazard associated with these low-level exposures. For peanut, there are now published data relating to over 3000 double-blind, placebo-controlled challenges in allergic individuals, but a similar level of evidence is lacking for other priority allergens. We present the results of a rapid evidence assessment and meta-analysis for the risk of anaphylaxis to a low-level allergen exposure for priority allergens. On the basis of this analysis, we propose that peanut can and should be considered an exemplar allergen for the hazard characterization at a low-level allergen exposure. (c) 2021 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

The typical methodology for comparing simulated galaxies with observational surveys is usually to apply a spatial selection to the simulation to mimic the region of interest covered by a comparable observational survey sample. In this work, we compare this approach with a more sophisticated post-processing in which the observational uncertainties and selection effects (photometric, surface gravity and effective temperature) are taken into account. We compare a 'solar neighbourhood analogue' region in a model MilkyWay-like galaxy simulated with RAMSES-CH with fourth release Gaia-ESO survey data. We find that a simple spatial cut alone is insufficient and that the observational uncertainties must be accounted for in the comparison. This is particularly true when the scale of uncertainty is large compared to the dynamic range of the data, e.g. in our comparison, the [Mg/Fe] distribution is affected much more than the more accurately determined [Fe/H] distribution. Despite clear differences in the underlying distributions of elemental abundances between simulation and observation, incorporating scatter to our simulation results to mimic observational uncertainty produces reasonable agreement. The quite complete nature of the Gaia-ESO survey means that the selection function has minimal impact on the distribution of observed age and metal abundances but this would become increasingly more important for surveys with narrower selection functions.© 2017 The Author(s). ; This is based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002 (the Gaia-ESO Public Spectroscopic Survey). We acknowledge the insightful comments and support provided by our colleagues Stefano Pasetto, Daisuke Kawata, Rob Thacker and Dimitris Stamatellos. We would thank the anonymous referee for a very constructive report of the work presented here. BBT acknowledges the support of STFC through its PhD Studentship Programme (ST/F007701/1). We also acknowledge the generous allocation of resources from the Partnership for Advanced Computing in Europe (PRACE) via the DEISA Extreme Computing Initiative (PRACE-3IP Project RI-312763 and PRACE-4IP Project 653838) and STFC's DiRAC Facility (COSMOS: Galactic Archaeology). CGF acknowledges funding from the European Research Council for the FP7 ERC starting grant project LOCALSTAR and the DiRAC Complexity system, operated by the University of Leicester IT Services, which forms part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). This equipment is funded by BIS National E-Infrastructure capital grant ST/K000373/1 and STFC DiRAC Operations grant ST/K0003259/1. DiRAC is part of the National E-Infrastructure. Continued access to the University of Hull's High Performance Computing Facility ('viper'), the HPC facility at the University of Central Lancashire and the computational facilities at Saint Mary's University are likewise gratefully acknowledged. TB was funded by the project grant 'The New Milky Way' from the Knut and Alice Wallenberg Foundation. SGS acknowledges the support by Fundacao para a Ciencia e Tecnologia (FCT) (ref: UID/FIS/04434/2013 & PTDC/FIS-AST/7073/2014 & Investigador FCT contract of reference IF/00028/2014) through national funds and by FEDER through COMPETE2020 (ref: POCI-01-0145-FEDER-007672 & POCI-01-0145-FEDER-016880). UH acknowledges support from the Swedish National Space Board (SNSB/Rymdstyrelsen). The Gaia-ESO Survey data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. These data have been obtained from the Gaia-ESO Survey Data Archive, prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council. This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Universita' e della Ricerca (MIUR) in the form of the grant 'Premiale VLT 2012'. The results presented here benefit from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. MTC acknowledge the financial support from the Spanish Ministerio de Economia y Competitividad, through grant AYA2013-40611-P. UH acknowledges support from the Swedish National Space Board (SNSB/Rymdstyrelsen). This work was supported by Sonderforschungsbereich SFB 881 'The Milky Way System' (subprojects A5, C9) of the German Research Foundation (DFG). This work benefited from discussions at GNASH workshop, Victoria supported by the National Science Foundation under Grant No. PHY-1430152 (JINA Center for the Evolution of the Elements). ARC is supported by Australian Research Council Grant DP160100637