Results are presented from the first cohort of a music, imagery, and movement (MiM) treatment intervention study conducted with residents in a long-term care facility. The pre–post two-group treatment design randomly assigned participants to the 10-week MiM intervention or 10-week conversational social control group (N = 20). Cognitive functioning and depression were assessed for all study participants at baseline and the end of treatment. Quantitative data showed an impact of MiM on depression score reduction, and qualitative data suggested that participants engaged in meaningful interpersonal experiences within the MiM group. Together, the data suggest that creative arts participation enhances positive social engagement, which may be a key therapeutic mechanism of change acting on depression scores differentially across the MiM group versus the social control conversation group.