Suchergebnisse

Otkriće, sinteza i terapijska primjena kortizona predstavljaju paradigmu moderne translacijske medicine (Hillier 2007, Saenger 2010) jer združuju otkrića biokemičara Edwarda Calvina Kendalla i Tadeusa Reichsteina; otkriće kemijske sinteze za široku primjenu industrijskog kemičara Lewisa Hastingsa Saretta i otkriće terapijske primjene reumatologa Philipa Showaltera Hencha. Cilj je translacijske medicine ubrzati proces između bazičnog istraživanja i kliničke prakse te integrirati različite discipline da bi se razumjeli različiti ishodi (Zhang et al. 2014). U ovome radu predstavit ću uvjete koji su omogućili ovu suradnju bazičnog, primijenjenog i kliničkog istraživanja: uspon steroidne kemije, istovremena pojedinačna dostignuća, kao i kontinuirana suradnja između znanstvenika, vojna kompetitivnost i suradnja između farmaceutskih kompanija. ; A discovery, synthesis and therapeutic application of cortisone present a paradigm for modern translational medicine (Hillier 2007, Saenger 2010), since they represented a joint achievement of discoveries by biochemists, Edward Calvin Kendall and Tadeus Reichstein; large scale synthesis by an industrial chemist, Lewis Hastings Sarett, and therapeutic application by a rheumatologist, Philip Showalter Hench. The goal of translational medicine is to speed up the process between basic research and clinical practice, and to integrate multiple disciplines in order to understand diverse outcomes (Zhang et al. 2014). In this paper conditions that made this basic/applied/clinical research interface possible will be presented: the rise of steroid chemistry, simultaneous individual accomplishments as well as continuous cooperation among scientists, military competitiveness, and cooperation among pharmaceutical companies.