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The combination of inspiration, science, and politics is a cornerstone precept for the common good of humanity, towards the fulfillment of social objectives. Based on this precept, this paper reviews core experiences of the Chilean Health Sector. Health sector key events taking place during the first half of the 20th century were the creation of the National Health Service and the development of mother and child healthcare policies. After the earthquake of 1939, the future President of Chile, Doctor Salvador Allende, set up the Special Sanitation Council, to balance policies.Also, he launched the Social Security reform process, which endured financing restrictions and the animosity of physicians opposing the socialization of medical care.ln 1951 the reform was approved, to extend coverage to blue collar workers and their families; separate health provision from healthcare security; emphasize preventive pediatric care in mother's health, and reproductive health. The basic tenets of healthcare reform were the right to health, solidarity, and equity, as the pillars of policy-making and healthcare programming. The question of whether the evolution of social security in Chile has been consistent with the original healthcare reform tenets is raised by the author. ; Partiendo de la premisa de que la conjunción de mística, ciencia y política escalones para un bien común destinado a la humanidad potencia la resolución de objetivos socialmente planteados, el presente documento revisa una parte medular de la experiencia en el Sector Salud en Chile, cuyos procesos hacia la primera mitad del siglo XX, como el nacimiento del Servicio Nacional de Salud y el desarrollo de políticas de atención materno infantil, figuran como parteaguas del actual sistema de salud chileno. Luego de la catástrofe ocasionada por el sismo de 1939, el futuro presidente de la nación, doctor Salvador Allende, establece el Consejo Especial de Salubridad, que equilibra políticas e impulsa una reforma a la Seguridad Social que enfrentó obstáculos de ...

Resumen.En este texto se indaga la participación de jóvenes de la población La Pincoya en la lucha armada desarrollada desde el Frente Patriótico Manuel Rodrí­guezn en los años ochenta, analizando cómo estos jóvenes construyeron un imaginario revolucionario, que los llevó a involucrarse en esta organización militar de izquierda desarrollando diversas acciones armadas para intentar derrocar al régimen. Al respecto, se afirma como hipótesis que en el escenario de amplias protestas sociales contra la dictadura, numerosos jóvenes de la población La Pincoya acogen el llamado del Partido Comunista de agudizar las formas de lucha, involucrándose en las recientemente creadas Unidades de Combate del FPMR.Este grupo armado se nutrió principalmente de miembros jóvenes de familias comunistas, quienes construyeron un imaginario revolucionario que los impulsó a participar en emblemáticas acciones que tení­an como propósito derrocar a Pinochet.Palabras clave: Población La Pincoya, Frente Patriótico Manuel Rodrí­guez, Dictadura militar, lucha armada. Creation of the revolutionary imaginary of pincoyanos youth and the armed struggle in Chile of the eighties.AbstractThis text analyzes the participation of La Pincoya settlement young people in the armed struggle developed by Frente Patriótico Manuel Rodrí­guez in the eighties and how these young people created a revolutionary imaginary whichled them to engage in this left wind military organization developing various armed actions trying to overthrow the regime. The hypotheses is that, in anenvironment of broad social protests against the dictatorship, many youngpeople from La Pincoya responded to the call of the Communist party forsharpening the struggle and engaged in the newly created Combat Units ofthe FPMR. This armed group was mainly fed by young members of communistfamilies, who built a revolutionary imaginary that prompted them to engagein symbolic actions intended to overthrow Pinochet.Keywords: La Pincoya settlement, Frente Patriótico Manuel Rodrí­guez,military dictatorship, armed struggle.

Abstract. The Upper Rhine Graben (URG), located in France and Germany, is bordered by north–south-trending faults, some of which are considered active, posing a potential threat to the dense population and infrastructures on the Alsace plain. The largest historical earthquake in the region was the M6.5±0.5 Basel earthquake in 1356. Current seismicity (M>2.5 since 1960) is mostly diffuse and located within the graben. We build upon previous seismic hazard studies of the URG by exploring uncertainties in greater detail and revisiting a number of assumptions. We first take into account the limited evidence of neotectonic activity and then explore tectonic scenarios that have not been taken into account previously, exploring uncertainties for Mmax, its recurrence time, the b value, and the moment released aseismically or through aftershocks. Uncertainties in faults' moment deficit rates, on the observed seismic events' magnitude–frequency distribution and on the moment–area scaling law of earthquakes, are also explored. Assuming a purely dip-slip normal faulting mechanism associated with a simplified model with three main faults, Mmax maximum probability is estimated at Mw 6.1. Considering this scenario, there would be a 99 % probability that Mmax is less than 7.3. In contrast, with a strike-slip assumption associated with a four-main-fault model, consistent with recent paleoseismological studies and the present-day stress field, Mmax is estimated at Mw 6.8. Based on this scenario, there would be a 99 % probability that Mmax is less than 7.6.

Introduction: The South American country Chile now boasts a life expectancy of over 80 years. As a consequence, Chile now faces the increasing social and economic burden of cancer and must implement political policy to deliver equitable cancer care. Hindering the development of a national cancer policy is the lack of comprehensive analysis of cancer infrastructure and economic impact. Objectives: Evaluate existing cancer policy, the extent of national investigation and the socio-economic impact of cancer to deliver guidelines for the framing of an equitable national cancer policy. Methods: Burden, research and care-policy systems were assessed by triangulating objective system metrics – epidemiological, economic, etc. – with political and policy analysis. Analysis of the literature and governmental databases was performed. The oncology community was interviewed and surveyed. Results: Chile utilizes 1% of its gross domestic product on cancer care and treatment. We estimate that the economic impact as measured in Disability Adjusted Life Years to be US$ 3.5 billion. Persistent inequalities still occur in cancer distribution and treatment. A high quality cancer research community is expanding, however, insufficient funding is directed towards disproportionally prevalent stomach, lung and gallbladder cancers. Conclusions: Chile has a rapidly ageing population wherein 40% smoke, 67% are overweight and 18% abuse alcohol, and thus the corresponding burden of cancer will have a negative impact on an affordable health care system. We conclude that the Chilean government must develop a national cancer strategy, which the authors outline herein and believe is essential to permit equitable cancer care for the country.

Abstract Introduction The South American country Chile now boasts a life expectancy of over 80 years. As a consequence, Chile now faces the increasing social and economic burden of cancer and must implement political policy to deliver equitable cancer care. Hindering the development of a national cancer policy is the lack of comprehensive analysis of cancer infrastructure and economic impact. Objectives Evaluate existing cancer policy, the extent of national investigation and the socio-economic impact of cancer to deliver guidelines for the framing of an equitable national cancer policy. Methods Burden, research and care-policy systems were assessed by triangulating objective system metrics – epidemiological, economic, etc. – with political and policy analysis. Analysis of the literature and governmental databases was performed. The oncology community was interviewed and surveyed. Results Chile utilizes 1% of its gross domestic product on cancer care and treatment. We estimate that the economic impact as measured in Disability Adjusted Life Years to be US$ 3.5 billion. Persistent inequalities still occur in cancer distribution and treatment. A high quality cancer research community is expanding, however, insufficient funding is directed towards disproportionally prevalent stomach, lung and gallbladder cancers. Conclusions Chile has a rapidly ageing population wherein 40% smoke, 67% are overweight and 18% abuse alcohol, and thus the corresponding burden of cancer will have a negative impact on an affordable health care system. We conclude that the Chilean government must develop a national cancer strategy, which the authors outline herein and believe is essential to permit equitable cancer care for the country.

Introduction: The South American country Chile now boasts a life expectancy of over 80 years. As a consequence, Chile now faces the increasing social and economic burden of cancer and must implement political policy to deliver equitable cancer care. Hindering the development of a national cancer policy is the lack of comprehensive analysis of cancer infrastructure and economic impact. Objectives: Evaluate existing cancer policy, the extent of national investigation and the socio-economic impact of cancer to deliver guidelines for the framing of an equitable national cancer policy. Methods: Burden, research and care-policy systems were assessed by triangulating objective system metrics - epidemiological, economic, etc. - with political and policy analysis. Analysis of the literature and governmental databases was performed. The oncology community was interviewed and surveyed. Results: Chile utilizes 1% of its gross domestic product on cancer care and treatment. We estimate that the economic impact as measured in Disability Adjusted Life Years to be US$ 3.5 billion. Persistent inequalities still occur in cancer distribution and treatment. A high quality cancer research community is expanding, however, insufficient funding is directed towards disproportionally prevalent stomach, lung and gallbladder cancers. Conclusions: Chile has a rapidly ageing population wherein 40% smoke, 67% are overweight and 18% abuse alcohol, and thus the corresponding burden of cancer will have a negative impact on an affordable health care system. We conclude that the Chilean government must develop a national cancer strategy, which the authors outline herein and believe is essential to permit equitable cancer care for the country. Keywords Author Keywords:Chile; Cancer policy; Investigation; Research and development; Statistics; Gallbladder cancer; Stomach cancer; Developing country

Background: Influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus are the most common viruses associated with acute lower respiratory infections in young children (<5 years) and older people (≥65 years). A global report of the monthly activity of these viruses is needed to inform public health strategies and programmes for their control. Methods: In this systematic analysis, we compiled data from a systematic literature review of studies published between Jan 1, 2000, and Dec 31, 2017; online datasets; and unpublished research data. Studies were eligible for inclusion if they reported laboratory-confirmed incidence data of human infection of influenza virus, respiratory syncytial virus, parainfluenza virus, or metapneumovirus, or a combination of these, for at least 12 consecutive months (or 52 weeks equivalent); stable testing practice throughout all years reported; virus results among residents in well-defined geographical locations; and aggregated virus results at least on a monthly basis. Data were extracted through a three-stage process, from which we calculated monthly annual average percentage (AAP) as the relative strength of virus activity. We defined duration of epidemics as the minimum number of months to account for 75% of annual positive samples, with each component month defined as an epidemic month. Furthermore, we modelled monthly AAP of influenza virus and respiratory syncytial virus using site-specific temperature and relative humidity for the prediction of local average epidemic months. We also predicted global epidemic months of influenza virus and respiratory syncytial virus on a 5° by 5° grid. The systematic review in this study is registered with PROSPERO, number CRD42018091628. Findings: We initally identified 37 335 eligible studies. Of 21 065 studies remaining after exclusion of duplicates, 1081 full-text articles were assessed for eligibility, of which 185 were identified as eligible. We included 246 sites for influenza virus, 183 sites for respiratory syncytial virus, 83 sites for parainfluenza virus, and 65 sites for metapneumovirus. Influenza virus had clear seasonal epidemics in winter months in most temperate sites but timing of epidemics was more variable and less seasonal with decreasing distance from the equator. Unlike influenza virus, respiratory syncytial virus had clear seasonal epidemics in both temperate and tropical regions, starting in late summer months in the tropics of each hemisphere, reaching most temperate sites in winter months. In most temperate sites, influenza virus epidemics occurred later than respiratory syncytial virus (by 0·3 months [95% CI −0·3 to 0·9]) while no clear temporal order was observed in the tropics. Parainfluenza virus epidemics were found mostly in spring and early summer months in each hemisphere. Metapneumovirus epidemics occurred in late winter and spring in most temperate sites but the timing of epidemics was more diverse in the tropics. Influenza virus epidemics had shorter duration (3·8 months [3·6 to 4·0]) in temperate sites and longer duration (5·2 months [4·9 to 5·5]) in the tropics. Duration of epidemics was similar across all sites for respiratory syncytial virus (4·6 months [4·3 to 4·8]), as it was for metapneumovirus (4·8 months [4·4 to 5·1]). By comparison, parainfluenza virus had longer duration of epidemics (6·3 months [6·0 to 6·7]). Our model had good predictability in the average epidemic months of influenza virus in temperate regions and respiratory syncytial virus in both temperate and tropical regions. Through leave-one-out cross validation, the overall prediction error in the onset of epidemics was within 1 month (influenza virus −0·2 months [−0·6 to 0·1]; respiratory syncytial virus 0·1 months [−0·2 to 0·4]). Interpretation: This study is the first to provide global representations of month-by-month activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus. Our model is helpful in predicting the local onset month of influenza virus and respiratory syncytial virus epidemics. The seasonality information has important implications for health services planning, the timing of respiratory syncytial virus passive prophylaxis, and the strategy of influenza virus and future respiratory syncytial virus vaccination. Funding: European Union Innovative Medicines Initiative Respiratory Syncytial Virus Consortium in Europe (RESCEU).