Exposure to In Utero Lipopolysaccharide Induces Inflammation in the Fetal Ovine Skin
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 18, Heft 1, S. 88-98
ISSN: 1933-7205
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In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 18, Heft 1, S. 88-98
ISSN: 1933-7205
In: Journal of the Society for Gynecologic Investigation: official publication of the Society for Gynecologic Investigation, Band 3, Heft 5, S. 250-258
ISSN: 1556-7117
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 23, Heft 1, S. 69-80
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 20, Heft 12, S. 1447-1454
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 18, Heft 11, S. 1128-1137
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 20, Heft 8, S. 946-956
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 18, Heft 11, S. 1092-1102
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 21, Heft 5, S. 623-631
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 24, Heft 1, S. 77-84
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 30, Heft 11, S. 3222-3234
ISSN: 1933-7205
AbstractDespite widespread use, dosing regimens for antenatal corticosteroid (ACS) therapy are poorly unoptimized. ACS therapy exerts a programming effect on fetal development, which may be associated with an increased risk of cardiovascular disease. Having demonstrated that low-dose steroid therapy is an efficacious means of maturing the preterm lung, we hypothesized that a low-dose steroid exposure would exert fewer adverse functional and transcriptional changes on the fetal heart. We tested this hypothesis using low-dose steroid therapy (10 mg delivered to the ewe over 36 h via constant infusion) and compared cardiac effects with those of a higher dose treatment (30 mg delivered to the ewe over 24 h by intramuscular injection; simulating currently employed clinical ACS regimens). Fetal cardiac function was assessed by ultrasound on the day of ACS treatment initiation. Transcriptomic analyses were performed on fetal myocardial tissue. Relative to saline control, fetuses in the higher-dose clinical treatment group had significantly lower ratios between early diastolic ventricular filling and ventricular filling during atrial systole, and showed the differential expression of myocardial hypertrophy-associated transcripts including βMHC, GADD45γ, and PPARγ. The long-term implications of these changes remain unstudied. Irrespective, optimizing ACS dosing regimens to maximize respiratory benefit while minimizing adverse effects on key organ systems, such as the heart, offers a means of improving the acute and long-term outcomes associated with this important obstetric therapy.
In: Bulletin of the World Health Organization: the international journal of public health = Bulletin de l'Organisation Mondiale de la Santé, Band 92, Heft 8, S. 605-612
ISSN: 1564-0604