Suchergebnisse

In recent years, a subgroup of B-cell precursor acute lymphoblastic leukemia (BCP ALL) without an established abnormality ("B-other") has been shown to be characterized by rearrangements of ABL1, ABL2, CSF1R, or PDGFRB (a.k.a. ABL-class genes). Using FISH with probes for these genes, we screened 55 pediatric and 50 adult B-other cases. Three (6%) of the adult but none of the childhood B-other cases were positive for ABL-class aberrations. RT-PCR and sequencing confirmed a rare SFPQ-ABL1 fusion in one adult B-other case with t(1;9)(p34;q34). Only six SFPQ-ABL1-positive BCP ALLs have been reported, present case included. A review of these shows that all harbored fusions between exon 9 of SFPQ and exon 4 of ABL1, that the fusion is typically found in adolescents/younger adults without hyperleukocytosis, and that IKZF1 deletions are recurrent. The few patients not treated with tyrosine kinase inhibitors (TKIs) and/or allogeneic stem cell transplantation relapsed, strengthening the notion that TKI should be added to the therapy of SFPQ-ABL1-positive BCP ALL. ; Funding Agencies|Swedish Childhood Cancer Foundation [PR2018-0004]; Swedish Cancer SocietySwedish Cancer Society [CAN 2017/291]; Swedish Research CouncilSwedish Research Council [2016-01084]; Governmental Funding of Clinical Research within the National Health Service; VetenskapsradetSwedish Research Council [2016-01084]

Presents some theoretical principles and empirical evidence
relating to the new Swedish production systems for final assembly of
motor vehicles. Contends that in these production systems it is possible
simultaneously to enhance efficiency and quality of working life.
Briefly sketches three production forms as they apply to the final
assembly of automobiles and discusses the societal environments in which
these different forms of production have evolved. Focuses on Volvo′s
Swedish Uddevalla plant as one of the main examples so far of a
reflective production system for final assembly of automobiles.
Amplifies the analysis of different production flow patterns for final
assembly and in particular addresses the issue of semi‐parallel
mechanistic production flow and parallel organic production flow as
alternatives to serial flow on a conventional line assembly.

n/a ; Funding Agencies|Swedish Cancer SocietySwedish Cancer Society [20 0792 PjF]; Swedish Childhood Cancer FoundationEuropean Commission [PR2018-0008, TJ2020-0024]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2020-01164]; Governmental Funding of Clinical Research within the National Health Service; LUNARC through Lund University [LSENS 2018/3-4]