Suchergebnisse

Aldosterone-to-renin ratio (ARR) is a screening test for primary aldosteronism, but it was impacted by a bunch of clinical covariates. The ARR is associated with chronic kidney disease (CKD), renal artery stenosis, renin adenoma. This study aims to investigate relationship between ARR and primary aldosteronism in CKD patients. A retrospective observational analysis involves 253 attendees from Urology Department of Chengdu Military General Hospital (China), comprising 146 patients with confirmed primary aldosteronism, 56 patients with essential hypertension, and 55 patients with chronic kidney disease accounting for primary kidney disease. Blood samples were drawn from patients with particular restriction for measuring serum aldosteronism, plasma renin activity, and serum potassium. Receiver operating characteristic (ROC) curve of ARR was tested to establish cutoff values and to assess sensitivity and specificity. The results showed that LogARR values were significantly higher (P < 0.001), and PRA and serum potassium values were significantly lower (P < 0.001) in primary aldosteronism patients. By contrast, significantly higher serum aldosterone and plasma renin were observed in CKDs compared with the other two groups (P < 0.001). There was a significantly positive correlation between LogARR and serum potassium (r = -0.0345, P < 0.001, R2 = 0.093). The AUC for plasma renin activity, logARR, and serum aldosterone are 0.855, 0.84, and 0.501, respectively. ROC curve of logARR and plasma renin activity in detection of primary aldosteronism with higher sensitivity and specificity. In conclusion, this study indicated that the ARR act as the biomarker for the primary aldosteronism, and could distinguish from chronic kidney disease.

The comprehensive description of the Russian language consciousness fragment, which is associated with the feeling of happiness, is introduced in conformity with the psycholinguistic approach to the analysis of linguistic facts. The article describes the associative field of the happiness lexeme in the Russian language. Some culturally rich cognitive features that form the content of the happiness as the feeling in the Russian linguistic consciousness have been identified with consideration of associative dictionaries. The analysis has resulted in determining some basic cognitive categories in the Russian language consciousness: emotion and feeling, belonging, object, evaluation, being, volume, space, time, state, action, characteristic, quality, expression, subject-person, reason, light, distance, goal, animals, desire, weight, color, place, food, value, attitude, degree, plant, others. The metaphorical models of the Happiness concept realization have been observed: happiness is a living being; happiness is light; happiness is a place to be; happiness is food; happiness is an object. They are characteristic and significant for the mentality of the Russian language native speakers. The algorithm suggested for the linguistic analysis of Happiness concept may be applied to the description of other emotive concepts. All the results obtained during the analysis, are relevant for the development of psycholinguistics and emotive linguistics.