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Introduction. The measles virus is still one of the main causes of morbidity and mortality in children and adults and is a threat of infectious outbreaks in many countries around the world. The World Health Organization (WHO), at the 2015 meeting in Europe, set out to eliminate measles infection. To control the elimination of this disease requires the accumulation of genotyping data of the detected measles virus to interrupt the situation of endemic spread. All six WHO regions have set a target for combating measles. In order to monitor and evaluate the degree of endemic circulation of measles virus (MV), the transmission chains of the epidemiologically relevant variants of MV identified in Central and Western Europe are analyzed. More systematic molecular monitoring and recording of MV transmission data between many countries can help to create a meaningful picture of the process of eliminating the problem of the occurrence and spread of measles infection. Goal. To study whether molecular surveillance meets the challenge of eliminating measles infection with the assurance of molecular data quality, continuity and intensity of molecular monitoring and analysis of transmission chains in different geographical regions. Material & methods. Published articles, molecular program for external WHO quality assessment, WHO EUR central infectious disease information system, and WHO measles surveillance database. Results & discussion. According to the WHO standardized nomenclature using the nucleotide (nt) sequences of the N and H variable genes, wild-type measles viruses are currently divided into 24 genotypes. The most variable is the 450-nt variable coding sequence of the C-terminal portion of the N protein (N-450 region) and is used to differentiate detected MV for observation. Antigenic differences between measles virus strains - representatives of different genotypes are minimal, all known genotypes of the virus belong to one serotype. Since the beginning of molecular surveillance in Europe in the early ...

Introduction. Today, measles is one of the most common endemic infections, which in the modern world affects not only children but also adults. Fifty percent of the world's incidence of measles is in five countries: Madagascar, Somalia, Liberia, the Democratic Republic of the Congo (DRC), and Ukraine. It should be noted that according to the WHO, Ukraine is one of the five countries with the highest incidence of measles, and since 2018 Ukraine ranks second in the world in the incidence of measles. The sharp increase in the incidence began in 2017, when 4,782 people fell ill with measles. In 2018, more than 54,000 Ukrainians contracted a measles infection, which is almost 64% of all cases registered in Europe. In 2019, the number of patients reached 57 thousand people. During 2017-2019, a total of more than 115 thousand people fell ill, of whom 41 died (including 25 children) [2].As for the Kharkiv region, in 2017-2019 there was also a surge in the incidence of measles infection. Given the goal of the WHO and UNESCO (2015) program to address the elimination of measles infection in the world [3], the effectiveness of which determines the timeliness of specific prevention and surveillance, it remains urgent to monitor measles infection to assess the degree of endemic circulation of measles in Kharkiv region. Material & methods. The material of our work was statistical data and reporting forms on epidemiological, virological and serological tests for measles infection in the Kharkiv region for 2017-2019, provided by the State Institution "Kharkiv OLC of the Ministry of Health of Ukraine" under the agreement on scientific and practical cooperation from 02.01. 2017. Results & discussion. In 2017, 11 cases of measles were registered (8 children and 3 adults), including 6 residents of Kharkiv, 3 in Barvinkivskyi, and 1 each in Kharkiv and Lozivskyi districts. Among the sick are 7 people of Roma nationality who do not have measles vaccinations. The diagnosis was confirmed in the laboratory in 9 patients. Starting ...