Suchergebnisse

Deckblatt; Titelseite; Impressum; Inhalt; 1. Vorwort; 2. Einleitung; Demografie in der Sozialwirtschaft; 3. Altersbilder und ihre Bedeutung für die Sozialwirtschaft; 4. Auswirkungen des demografischen Wandels auf die Personalentwicklung in der Diakonie; 5. Beschäftigungstrends in der Sozialwirtschaft und der Diakonie am Beispiel Jugendsozialarbeit und Jugendberufshilfe; 6. Arbeitsfeld Jugendsozialarbeit. Verlierer des Föderalismus oder Beruf(ung) mit Zukunft?; 7. Migration und demografischer Wandel. Interkulturelle Öffnung als Perspektive der Sozialwirtschaft; Kompetenz und Entwicklung

Die praktische Umsetzung des GHS-Gefahrstoffrechts bis Mitte 2015 drängt, gleichzeitig sind immer noch nationale Auslegungsvorschriften im Umbruch. Wie soll man damit umgehen? - Die 6. Auflage: - * berücksichtigt neuste rechtliche Änderungen der EG-CLP-Verordnung, Technischen Regeln für Gefahrstoffe (TRGS) und ApBetrO, - * beantwortet, was in der Apothekenpraxis sofort getan werden muss und wo Übergangsfristen genutzt werden können, - * vermittelt Lösungen, wie die Anforderungen in der Apotheke einfach bewältigt werden. - Dieses Werk hilft, die gefahrstoffrechtlichen Vorschriften zu verstehen und Schritt für Schritt einzuführen.

AbstractNeurofibromatosis type 1 (NF1) is the most frequent neurocutaneous disorder with autosomal dominant inheritance. Phenotype variability is high ranging from merely several café-au-lait spots to malignant peripheral nerve sheath tumors or severe disfigurement through plexiform neurofibromas. Identification of genetic factors that modify the NF1 phenotype would contribute to the understanding of NF1 pathophysiology and improve patient counselling. As even monozygotic (MZ) twins with NF1 may differ phenotypically, we wondered whether these variations might be inherited in a non-Mendelian fashion. Mitochondrial DNA (mtDNA) is inherited extrachromosomally through the cytoplasm of the oocyte and often harbours heteroplasmic sequence variations. At the time of blastomere separation, these variants may be skewedly distributed and effect phenotypic differences. Because of their co-localization with the tumor suppressor protein neurofibromin, which is mutated in NF1, mitochondria were particular attractive candidates for investigation. MtDNA was extracted from nucleated blood cells of four pairs of discordant MZ twins with NF1 and from cutaneous neurofibromas of one twin pair. We sequenced the entire mitochondrial genome and determined the state of heteroplasmy by investigating a microsatellite region of the mitochondrial D-loop (D310-tract). The clinical diagnosis was confirmed in all patients by detection of pathogenic mutations in the NF1 gene. Monozygosity was verified by genotyping. However, we did not detect evidence for mtDNA sequence differences or for different degrees of heteroplasmy between individuals of the same twin pair. The phenotypic discordance of MZ twins with NF1 cannot be explained by skewed distribution of mtDNA mutations or polymorphisms.

Der Band untersucht - ausgehend von den Impulsen der Wittenberger Reformation - den Zusammenhang zwischen der Rechtfertigungslehre und dem sozialen Engagement der Christen bzw. Kirchen. Luthers These war, dass Christen spontan Nächstenliebe üben würden. Aber ist das plausibel? Sind Christen folglich sozialer? Historische Beiträge heben in dieser Perspektive Entwicklungen in der Neugestaltung sozialer Versorgung nach 1517 hervor und beleuchten die Zusammenhänge mit der Entstehung des modernen Sozialstaats. Die Bedeutung von Nächstenliebe und Altruismus für die heutige Arbeit der Diakonie wird mit theoretischen und empirischen Analysen unterfüttert. Ergänzt durch Beiträge aus der diakonischen Praxis treten Vorzüge und Ambivalenzen von Nächstenliebe im professionellen sozialen Handeln deutlich hervor. [Ambivalences of Charity. Social Consequences of the Reformation] This volume examines - based on the ideas of the Wittenberg Reformation - the correlation between the doctrine of justification and the social commitment of Christians and Churches. Luther assumed that Christians would serve their neighbour spontaneously. Is this plausible? Are Christian people generally more socially-minded? Historic contributions highlight the development in the reorganisation of social care after 1517 and examine the interrelation with the formation of the modern welfare state. Theoretical and empirical studies acknowledge the significance of charity and altruism for the present-day work of diaconia. Supplementary comments from diaconic practice show the benefits as well as ambiguities of Christian charity within professional social work.

Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder caused by heterozygotic inactivation of the NF1 tumor suppressor gene at 17q11.2. The associated phenotypes are highly variable, and modifying genes have been proposed to explain at least in part the intriguing expressivity. Given that haploinsufficiency of the NF1 gene product neurofibromin is responsible for some of the clinical manifestations, variations in expression of the wildtype NF1 allele might modify the phenotype. We therefore investigated epigenetic molecular modifications that could result in variable expression of the normal NF1 allele. To exclude confounding by DNA sequence variations, we analyzed monozygotic twin pairs with NF1 who presented with several discordant features. We fine-mapped the methylation pattern of a nearly 1 kb NF1 promoter region in lymphocytes of 8 twin pairs. All twin pairs showed significant intra-pair differences in methylation, especially of specific promoter subregions such as 5'UTR, exon 1 and intron 1 (+7 to +622), transcription factor binding sites and promoter elements like NF1HCS. Furthermore, we detected significant intra-pair differences in cytosine methylation for the region from -249 to -234 with regard to discordance for optic glioma with a higher grade of methylation in glioma cases. In conclusion, our findings of epigenetic differences of the NF1 promoter in leukocytes within mono zygotic twin pairs may serve as a proof of principle for other tissues. The results point towards a role of methylation patterns of the normal NF1 allele for expression differences and for modification of the NF1 phenotype.