Suchergebnisse

Starting from a happy life where the human settlement and Komodo dragons live side by side. Generation to another generation, the people of Komodo village have believed in totemism from the legend of Princess Najo who gave birth to two male twins, one in the form of a human and one in the form of a Komodo dragon. At that time, humans shared their prey with the Komodo dragons. Now the Komodo village, whose life is in the tourism sector, will be allocated to another island by the government. When the Komodo people are restless, many dragons swim everywhere. There is a flesh and blood relationship between the Komodo dragon and humans. The residents balked and would rather die than have to move from the village which they called their "spilled blood". Plus the threat of a break in the Komodo dragon's food chain due to illegal poaching of Timor deer by illegal communities. The purpose of this research focuses on raising the nobility value of the Komodo village with the existence of the Komodo dragon due to the breaking of the traditional totemism chain and the scarcity of the Komodo dragon. This research uses a spatial machine method which aims to turn on the Komodo dragon's breathing space which is mutualized with the daily life of the village based on the legend of Putri Najo to its original locus in the past. The experience that the author shares is a thought in planning social systems and ecosystems on Komodo Island in response to "Beyond Ecology". A typology of conservation buildings that aims to protect, care for, breed where the Komodo dragon is not just an animal, but is a blood relative. Keywords: Komodo dragon; Putri Najo; Spatial Machine AbstrakBerawal dari kehidupan yang bahagia dimana perkampungan manusia dengan komodo hidup saling berdampingan. Secara turun-temurun, masyarakat desa Komodo memiliki kepercayaan totemisme dari kisah legenda Putri Najo yang melahirkan dua anak kembar laki-laki, yang satu berwujud manusia dan satu lagi berwujud komodo. Pada masa itu, manusia saling membagikan hasil buruannya kepada komodo. Sekarang kampung Komodo yang hidupnya pada sektor pariwisata akan dialokasikan ke pulau lain oleh pemerintah. Ketika orang Komodo gelisah, banyak komodo berenang kemana-mana. Terasa ada hubungan darah daging dan batin antara komodo dengan manusia. Warga menolak keras dan lebih baik mati daripada harus pindah dari desa yang mereka sebut 'tumpah darah' mereka. Ditambah ancaman putusnya rantai makanan komodo akibat perburuan liar rusa Timor oleh masyarakat ilegal. Tujuan dari penelitian ini berfokus dalam mengangkat nilai keluhuran desa Komodo dengan keberadaan komodo akibat putusnya rantai tradisi totemisme dan kelangkaan komodo. Penelitian ini menggunakan metode mesin keruangan bertujuan menghidupkan ruang nafas komodo yang bermutualisasi dengan keseharian desa diangkat dari kisah legenda Putri Najo ke lokus aslinya di masa lampau. Pengalaman yang penulis bagikan merupakan sebuah pemikiran perencanaan sistem sosial dan ekosistem di Pulau Komodo sebagai jawaban dari "Melampaui Ekologi". Tipologi bangunan konservasi yang bertujuan melindungi, merawat, mengembangbiakkan dimana komodo bukan sekadar hewan, tetapi saudara sedarah.

Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. Methods: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. Results: Thirty-nine lipids were associated with obesity and eight with dysglycemia in the FHS. Of 32 lipids that were available for replication for obesity and six for dyslipidemia, 28 (88%) replicated for obesity and five (83%) for dysglycemia. Four lipids were associated with longitudinal changes in body mass index and four were associated with changes in fasting blood glucose in the FHS. Conclusions: We identified and replicated several novel lipid biomarkers of key metabolic traits. The lipid moieties identified in this study are involved in biological pathways of metabolic risk and can be explored for prognostic and therapeutic utility. ; The Framingham Heart Study is funded by National Institutes of Health (NIH) contract N01-HC-25195. This study was made possible by a CRADA between BG Medicine, Inc., Boston University, and the NHLBI, and the laboratory work for this research was supported by the Division of Intramural Research of the National Heart, Lung, and Blood Institute (NHLBI). Analytical work was funded by the Division of Intramural Research of NHLBI as well as the Center for Information Technology, NIH, Bethesda, MD. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. The PESA study is supported by a non-competitive unrestricted grant shared between the National Center for Cardiovascular Research Carlos III (CNIC) and the Bank of Santander. The PESA study is a noncommercial study independent of the health and pharmaceutical industry. The CNIC is supported by the Spanish Ministry of Science, Innovation and Universities, the Instituto de Salud Carlos III, and the proCNIC Foundation. The study was partially funded by a grant from AstraZeneca (TANSNIP project). JMO is supported by the US Department of Agriculture, under agreement no. 8050-51000-098-00D. MPO and MJ acknowledge an Institute of Health Carlos III grant (PI 17-00134). This research was in part funded by the Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (PI14/00328), co-financed by FEDER funds from the European Union ('A way to built Europe'), and the Generalitat of Catalonia, Department of Health(SLT002/16/00250) and Department of Business and Knowledge(2017SGR696) to R.P. MJ is a Serra Húnter Fellow.

BACKGROUND: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. METHODS: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. RESULTS: Thirty-nine lipids were associated with obesity and eight with dysglycemia in the FHS. Of 32 lipids that were available for replication for obesity and six for dyslipidemia, 28 (88%) replicated for obesity and five (83%) for dysglycemia. Four lipids were associated with longitudinal changes in body mass index and four were associated with changes in fasting blood glucose in the FHS. CONCLUSIONS: We identified and replicated several novel lipid biomarkers of key metabolic traits. The lipid moieties identified in this study are involved in biological pathways of metabolic risk and can be explored for prognostic and therapeutic utility. ; The Framingham Heart Study is funded by National Institutes of Health (NIH) contract N01-HC-25195. This study was made possible by a CRADA between BG Medicine, Inc., Boston University, and the NHLBI, and the laboratory work for this research was supported by the Division of Intramural Research of the National Heart, Lung, and Blood Institute (NHLBI). Analytical work was funded by the Division of Intramural Research of NHLBI as well as the Center for Information Technology, NIH, Bethesda, MD. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. The PESA study is supported by a non-competitive unrestricted grant shared between the National Center for Cardiovascular Research Carlos III (CNIC) and the Bank of Santander. The PESA study is a noncommercial study independent of the health and pharmaceutical industry. The CNIC is supported by the Spanish Ministry of Science, Innovation and Universities, the Instituto de Salud Carlos III, and the proCNIC Foundation. The study was partially funded by a grant from AstraZeneca (TANSNIP project). JMO is supported by the US Department of Agriculture, under agreement no. 8050-51000-098-00D. MPO and MJ acknowledge an Institute of Health Carlos III grant (PI 17-00134). This research was in part funded by the Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (PI14/00328), co-financed by FEDER funds from the European Union ('A way to built Europe'), and the Generalitat of Catalonia, Department of Health(SLT002/16/00250) and Department of Business and Knowledge(2017SGR696) to R.P. MJ is a Serra Hunter Fellow. ; Sí