Suchergebnisse

Abstract
Through the Mas receptor, angiotensin-(1-7) [Ang-(1-7)] has been shown to have a key role in the development of lung inflammation. This systematic review (SR) sought to identify the relationship between lung damage brought on by exposure to cigarette smoke (CS) and the ACE2-Ang-(1-7)–Mas pathway. In this investigation, relevant keywords were used to search PubMed (MEDLINE), Scopus (Elsevier), and Institute for Scientific Information (ISI) Web of Science up to December 2022. Nine studies were chosen because they satisfied the inclusion/exclusion criteria. The majority of research concluded that exposure to CS increased the risk of lung damage. Smoking cigarettes is the main cause of COPD because it causes massive amounts of reactive oxygen and nitrogen species to enter the lungs, which stimulate the production of inflammatory cytokines like IL-1 β, IL-6, and TNF-α, as well as the invasion of inflammatory cells like neutrophils and macrophages. These findings support the renin-angiotensin system's (RAS) involvement in the pathophysiology of smoking-induced damage. Additionally, via stimulating pro-inflammatory mediators, aberrant RAS activity has been linked to lung damage. Lung inflammation's etiology has been shown to be significantly influenced by the protective known RAS arm ACE2-Ang-(1-7)–Mas. In conclusion, these are important for informing policymakers to pass legislation limiting the use of smoking and other tobacco to prevent their harmful effects.

"Mental disorders clearly are among the major challenges of global health causing many concerns for health systems, health experts, and health policy makers. The present study was conducted to evaluate the mental health program in comprehensive health centers and health houses under the coverage of Ilam University of Medical Sciences in the West of Iran. The present study was conducted based on the reports obtained from the mental health program in 2019. The data were recorded into registration and evaluation forms of mental disorders with the codes 102-19-03 and 102-19-01 and then entered into the Excel software. The prevalence per 100 and 100,000 people, as well as their 95% confidence intervals were calculated using Formula 1 ROUND (Number of cases*100000/population) and Formula 2 ROUND (Prevalence ±1.96*SQRT (Prevalence *(1- Prevalence)/population). The results showed that the prevalence of depression was 19,100 [95% CI: 18999-19201] 19100), and the prevalence of anxiety was 304,66 [95% CI: 20348-30584] per 100,000 population. The highest prevalence among mental disorders was related to depression and anxiety. Considering the high average score of mental health status in people over 65 years old, it is necessary to implement measures and interventions to improve these individuals' mental condition and upgrade their mental health."

"Mental disorders clearly are among the major challenges of global health causing many concerns for health systems, health experts, and health policy makers. The present study was conducted to evaluate the mental health program in comprehensive health centers and health houses under the coverage of the Ilam University of Medical Sciences in the West of Iran. The present study was conducted based on the reports obtained from the mental health program in 2019. The data were recorded into registration and evaluation forms of mental disorders with the codes 102-19-03 and 102-19-01 and then entered into the Excel software. The prevalence per 100 and 100,000 people, as well as their 95% confidence intervals, were calculated using Formula 1 ROUND (Number of cases*100000/population) and Formula 2 ROUND (Prevalence ±1.96*SQRT (Prevalence *(1- Prevalence)/population). The results showed that the prevalence of depression was 19,100 [95% CI: 18999-19201] 19100), and the prevalence of anxiety was 304,66 [95% CI: 20348-30584] per 100,000 population. The highest prevalence among mental disorders was related to depression and anxiety. Considering the high average score of mental health status in people over 65 years old, it is necessary to implement measures and interventions to improve these individuals' mental conditions and upgrade their mental health."