Suchergebnisse

Objective: Confirm the factor structure of the original 18-item Medical Outcome Study Social Support Survey (MOS-SSS) as well as two abbreviated versions in a sample of mothers with a child in mental health treatment. Method: The factor structure, internal consistency, and concurrent validity of the MOS-SSS were assessed using a convenience sample of 330 mothers. Results: A 12-item version that included subscales and a 4-item version maintained a good fit. Conclusion: 12- and 4-item versions of the MOS-SSS are psychometrically sound social support instruments and are appropriate for clinical and research uses. Given the diverse populations that social work serves, confirming instruments in various samples is important to legitimize an instrument's use and advance the evidence base for support interventions.

This study has been funded by Instituto de Salud Carlos III through the project PI13-02576 (co-funded by European Regional Development Fund "A way to make Europe") and Regional Government of Andalusia (SAS PI-0458-2016 and salud-2016-73581-tra). The work of alvaro Sierra-Sanchez was supported by a predoctoral fellowship (BOE 05/01/2018) funded by Instituto de Salud Carlos III (co-funded by European Social Fund "Investing in your future") with the dossier number FI18/00269. This study is part of his doctoral research in the Biomedicine's program of University of Granada. ; Wound healing is an important function of skin; however, after significant skin injury (burns) or in certain dermatological pathologies (chronic wounds), this important process can be deregulated or lost, resulting in severe complications. To avoid these, studies have focused on developing tissue-engineered skin substitutes (TESSs), which attempt to replace and regenerate the damaged skin. Autologous cultured epithelial substitutes (CESs) constituted of keratinocytes, allogeneic cultured dermal substitutes (CDSs) composed of biomaterials and fibroblasts and autologous composite skin substitutes (CSSs) comprised of biomaterials, keratinocytes and fibroblasts, have been the most studied clinical TESSs, reporting positive results for different pathological conditions. However, researchers' purpose is to develop TESSs that resemble in a better way the human skin and its wound healing process. For this reason, they have also evaluated at preclinical level the incorporation of other human cell types such as melanocytes, Merkel and Langerhans cells, skin stem cells (SSCs), induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs). Among these, MSCs have been also reported in clinical studies with hopeful results. Future perspectives in the field of human-TESSs are focused on improving in vivo animal models, incorporating immune cells, designing specific niches inside the biomaterials to increase stem cell potential and developing three-dimensional bioprinting strategies, with the final purpose of increasing patient's health care. In this review we summarize the use of different human cell populations for preclinical and clinical TESSs under research, remarking their strengths and limitations and discuss the future perspectives, which could be useful for wound healing purposes. ; Instituto de Salud Carlos III European Commission PI13-02576 BOE 05/01/2018 FI18/00269 ; European Regional Development Fund "A way to make Europe" ; Junta de Andalucia SAS PI-0458-2016 salud-2016-73581-tra ; European Social Fund "Investing in your future"