This surveillance report summarises the information from the I-MOVE-COVID-19 primary care surveillance networks to monitor the COVID-19 pandemic in seven European countries. The I-MOVE-COVID-19 surveillance in primary care aims to reinforce and complement the COVID-19 epidemiological data in the EU/EEA and the UK, compiled and reported by ECDC. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673
This document presents the core I-MOVE-COVID-19 European protocol for the hospital-based study of potential risk and protective factors for severe COVID-19 in hospitalised COVID-19 patients, outlining the agreed methods for collecting COVID-19 and SARS-CoV-2 in each of the individual studies, and including a plan for the pooled analysis. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673
Generic protocol for measuring COVID-19 vaccine effectiveness at primary care level in Europe - part of the I-MOVE-COVID-19 project ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673.
This document presents the core I-MOVE-COVID-19 European protocol for measuring risk and protective factors for COVID-19 at primary care level. The COVID-19 vaccine effectiveness is separate to this. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673 .
Generic protocol for measuring COVID-19 vaccine effectiveness at primary care level in Europe - part of the I-MOVE-COVID-19 project ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673.
This document presents the core I-MOVE-COVID-19 European protocol for the 2020 hospital-based study of vaccine effectiveness against COVID-19 in hospitalised SARI patients of all ages, outlining the agreed methods for collecting data on COVID-19 and SARS-CoV-2 in each of the individual studies, and including a plan for the pooled analysis. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673
This document presents the core I-MOVE-COVID-19 European protocol for the 2020 hospital-based study of vaccine effectiveness against COVID-19 in hospitalised SARI patients of all ages, outlining the agreed methods for collecting data on COVID-19 and SARS-CoV-2 in each of the individual studies, and including a plan for the pooled analysis. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673
This document presents the core European protocol for the hospital-based surveillance component of I-MOVE-COVID-19 for 2020, outlining the agreed methods for collecting COVID-19 and SARS-CoV2 data during this pandemic. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673
A generic protocol for COVID-19 surveillance at primary care level - from the I-MOVE-COVID-19 project. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101003673
I-MOVE/I-MOVE+ study team: Portugal - Baltazar Nunes, Ausenda Machado, Ana Paula Rodrigues, Verónica Gomez, Irina Kislaya, Mafalda Sousa Uva (Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo Jorge); Raquel Guiomar, Pedro Pechirra, Paula Cristóvão, Patrícia Conde, Inês Costa (Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Doutor Ricardo Jorge). ; I-MOVE/I-MOVE+study team - Portugal: Baltazar Nunes, Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge; Ausenda Machado, Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge; Ana Paula Rodrigues, Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge; Verónica Gomez, Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge; Irina Kislaya, Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge; Mafalda Sousa Uva, Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge; Raquel Guiomar, Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge; Pedro Pechirra, Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge; Paula Cristóvão, Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge; Patrícia Conde, Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo; Jorge Inês Costa, Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge. ; We measured early 2016/17 season influenza vaccine effectiveness (IVE) against influenza A(H3N2) in Europe using multicentre case control studies at primary care and hospital levels. IVE at primary care level was 44.1%, 46.9% and 23.4% among 0-14, 15-64 and ≥ 65 year-olds, and 25.7% in the influenza vaccination target group. At hospital level, IVE was 2.5%, 7.9% and 2.4% among ≥ 65, 65-79 and ≥ 80 year-olds. As in previous seasons, we observed suboptimal IVE against influenza A(H3N2). ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 634446. ; info:eu-repo/semantics/publishedVersion
Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. ; Funding: The five studies have received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed to fund some study sites of the EU-PC study under the Framework contract No ECDC/2014/026 for the individuals aged less than 65 years. All study teams are very grateful to all patients, general practitioners, paediatricians, hospital teams, laboratory teams, regional epidemiologists who have contributed to the studies. We acknowledge the authors, originating and submitting laboratories of the sequences from GISAID's EpiFlu Database used for this study. All submitters of data may be contacted directly via the GISAID website www.gisaid.org ; Sí
In the first five I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe) influenza seasons vaccine effectiveness (VE) results were relatively homogenous among participating study sites. In 2013-2014, we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in six European Union (EU) countries to measure 2013-2014 influenza VE against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. Influenza A(H3N2) and A(H1N1)pdm09 viruses co-circulated during the season. Practitioners systematically selected ILI patients to swab within eight days of symptom onset. We compared cases (ILI positive to influenza A(H3N2) or A(H1N1)pdm09) to influenza negative patients. We calculated VE for the two influenza A subtypes and adjusted for potential confounders. We calculated heterogeneity between sites using the I(2) index and Cochrane's Q test. If the I(2) was 49% we used a two-stage random effects model. We included in the A(H1N1)pdm09 analysis 531 cases and 1712 controls and in the A(H3N2) analysis 623 cases and 1920 controls. For A(H1N1)pdm09, the Q test (p=0.695) and the I(2) index (0%) suggested no heterogeneity of adjusted VE between study sites. Using a one-stage model, the overall pooled adjusted VE against influenza A(H1N1)pdm2009 was 47.5% (95% CI: 16.4-67.0). For A(H3N2), the I(2) was 51.5% (p=0.067). Using a two-stage model for the pooled analysis, the adjusted VE against A(H3N2) was 29.7 (95% CI: -34.4-63.2). The results suggest a moderate 2013-2014 influenza VE against A(H1N1)pdm09 and a low VE against A(H3N2). The A(H3N2) estimates were heterogeneous among study sites. Larger sample sizes by study site are needed to prevent statistical heterogeneity, decrease variability and allow for two-stage pooled VE for all subgroup analyses. ; Sí
European IVE Group - Portuguese Team: Verónica Gomez, Irina Kislaya, Baltazar Nunes, Ana Paula Rodrigues Ausenda Machado (Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo Jorge); Patrícia Conde, Inês Costa, Paula Cristóvão, Pedro Pechirra, Raquel Guiomar (Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Doutor Ricardo Jorge). ; Seasonal influenza vaccine is recommended in all European Union (EU) countries for older people and others at increased risk of severe influenza and its complications, including those with chronic diseases. In the United Kingdom (UK), incremental introduction of a universal childhood influenza vaccination programme began in 2013/14. The World Health Organization (WHO) recommendations for trivalent influenza vaccine strains for the 2018/19 northern hemisphere influenza season included an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Singapore/INFIMH-16–0019/2016 (H3N2)-like virus and a B/Colorado/06/2017-like virus from the B/Victoria lineage. The early 2018/19 influenza season in Europe was characterised by both influenza A virus subtypes circulating widely. There was co-circulation in some countries, with others reporting dominance of either A(H1N1)pdm09 or A(H3N2) viruses. The season started late in most countries compared with previous seasons, with few influenza B viruses detected in the WHO European Region. Since the 2008/09 season, the UK, Denmark, Spain, and several other EU countries conducting multicentre studies, have participated in I-MOVE (Influenza – Monitoring Vaccine Effectiveness in Europe), a network measuring influenza vaccine effectiveness each season. Interim results from six established influenza VE studies across Europe for the 2018/19 season indicate that VE against laboratory-confirmed influenza A ranged between 32% and 43% among all ages in primary care and hospital settings and was 59% in the target groups for vaccination. ; ECDC ; info:eu-repo/semantics/publishedVersion
Members of the I-MOVE+ working group - Portugal: B. Nunes, A. Machado, A.P. Rodrigues, V. Gómez, I. Kislaya, R. Guiomar, P. Pechirra, P. Cristóvão, I. Costa (National Health Institute Doutor Ricardo Jorge, Lisbon), A.Panarra, R. Côrte-Real (Centro Hospitalar de Lisboa Central, Lisbon), J. Poças, M.J. Peres (Centro Hospitalar de Setúbal, Setúbal). ; Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. ; The five studies have received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed to fund some study sites of the EU-PC study under the Framework contract No ECDC/2014/026 for the individuals aged less than 65 years. ; info:eu-repo/semantics/publishedVersion
Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2014/15. We undertook a multicentre case-control study in eight European countries to measure 2014/15 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed all or a systematic sample of ILI patients. We compared the odds of vaccination of ILI influenza positive patients to negative patients. We calculated adjusted VE by influenza type/subtype, and age group. Among 6,579 ILI patients included, 1,828 were A(H3N2), 539 A(H1N1)pdm09 and 1,038 B. VE against A(H3N2) was 14.4% (95% confidence interval (CI): -6.3 to 31.0) overall, 20.7% (95%CI: -22.3 to 48.5), 10.9% (95%CI -30.8 to 39.3) and 15.8% (95% CI: -20.2 to 41.0) among those aged 0-14, 15-59 and ≥60 years, respectively. VE against A(H1N1)pdm09 was 54.2% (95%CI: 31.2 to 69.6) overall, 73.1% (95%CI: 39.6 to 88.1), 59.7% (95%CI: 10.9 to 81.8), and 22.4% (95%CI: -44.4 to 58.4) among those aged 0-14, 15-59 and ≥60 years respectively. VE against B was 48.0% (95%CI: 28.9 to 61.9) overall, 62.1% (95%CI: 14.9 to 83.1), 41.4% (95%CI: 6.2 to 63.4) and 50.4% (95%CI: 14.6 to 71.2) among those aged 0-14, 15-59 and ≥60 years respectively. VE against A(H1N1)pdm09 and B was moderate. The low VE against A(H3N2) is consistent with the reported mismatch between circulating and vaccine strains. ; Sí
