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Introduction: Sexual pleasure has been a neglected issue in sexual health policies. Emerging trends in public health, however, emphasize the importance of sexual pleasure in preventing negative sexual health outcomes. Methods: Using data from the German Sexuality and Health Survey (GeSiD), we tested the assumption that sexual pleasure is associated with sexual health, including a special focus on the role of gender. Participants were interviewed about their sexual experiences and health between October 2018 and September 2019. The analytical sample included 3472 partnered and single women and men who had been sexually active with a partner in the past 12 months. We examined if sexual pleasure was associated with various sexual health indicators (i.e., communication about sexually transmitted infections (STIs), condom use, and absence of sexual problems). Results: Women reported less sexual pleasure than men. Results further indicate that sexual pleasure was associated with more sexual health indicators in women than in men. Conclusions: Supporting emerging trends in public health our results emphasize the importance of sexual pleasure in preventing negative sexual health outcomes. Policy Implications: To promote (especially women's) sexual health, our results call for the implementation of comprehensive sexuality education programs that focus on more positive aspects of sex, such as sexual pleasure and agency.

Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention. ; This work was supported by the Max Planck Society, the Max Planck Förderstiftung, the DFG (CNMPB), EXTRABRAIN EU-FP7, the Niedersachsen-Research Network on Neuroinfectiology (N-RENNT), and EU-AIMS. The research of EUAIMS receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n°115300, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007–2013), from the EFPIA companies, and from Autism Speaks. Moreover, support from Centro de Investigación en Red de Salud Mental (CIBERSAM); Instituto de Salud Carlos III (PI16/00998), Comissionat per a Universitats i Recerca del DIUE (2014SGR1636) and Spanish Ministry of Economy and Competitiveness (ES-EUEpiBrain, SAF2015-71526-REDT) is gratefully acknowledged. We thank all subjects for participating in the study, and all the many colleagues who have contributed over the past decade to the GRAS data collection.

Zum Jubiläum des Instituts für Sexualforschung des Universitätsklinikums Hamburg-Eppendorf setzen sich ehemalige und aktuelle Institutsmitglieder mit sexualwissenschaftlichen Forschungsfeldern und sexualpolitischen Kontroversen auseinander. In autobiografischen Berichten zeigen die renommierten Autorinnen und Autoren Verbindungen zwischen ihren individuellen Lebensläufen und Forschungswegen auf. Beiträge zu gegenwärtigen und zukünftigen Fragen des Feminismus, der Kriminalprognostik und der Sexualpädagogik runden diesen breiten Einblick in die Sexualforschung ab. Mit Beiträgen von Inga Becker, Nikolaus Becker, Wolfgang Berner, Maika Boehm, Peer Briken, Sabine Cassel-Bähr, Ulrich Clement, Martin Dannecker, Arne Dekker, Annika Flöter, Fritjof von Franqué, Johannes Fuß, Hans Giese, Margret Hauch, Andreas Hill, Judith Iffland, Reinhardt Kleber, Verena Klein, Thula Koops, Ute Lampalzer, Moritz Liebeknecht, Hannah Lietz, Silja Matthiesen, Timo Nieder, Will Preuss, Martin Rettenberger, Hertha Richter-Appelt, Gunter Schmidt, Eberhard Schorsch, Katinka Schweizer, Volkmar Sigusch, Andreas Spengler, Bernhard Strauß, Elisabeth Stück, Safiye Tozdan, Daniel Turner und Dalnym Yoon.