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Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward.

Following Richard Neustadt, scholarship on the presidency tends to focus on presidents as single‐minded seekers of political power. But, precisely because of the grandness of their political stage, presidents may, in fact, have constitutional ambitions concerning not how much power they will have but how they will wield their constitutional powers. James Madison's presidency provides an important case study of a president's constitutional ambitions. Entering office with constitutional concerns about the power of the presidency relative to the other branches, Madison used his own presidency and especially the War of 1812 to model a new type of constitutional office that he thought would fit better in the system of the separation of powers.

Even as he recommends it as the extra-constitutional solution to the inefficiencies and insufficiencies of legislative constitutionalism, Locke'sSecond Treatiseis far more aware of the dangers of executive prerogative than the more optimistic accounts in the recent scholarship have appreciated, making Locke pessimistic about the permanent sustenance of legislative constitutionalism. This pessimism stems from Locke's recognition that the people are far too constitutionally passive for the vigilance essential to 'umpire' well the necessity of executive action outside the laws. In fact, liberalism itself can contribute to such passivity: the people are content to allow an executive to act with a significant degree of discretion outside the laws so long as those actions do not interfere with their short-term interest in security and prosperity. Understanding Locke's pessimism regarding popular vigilance casts into new light his argument for a legislative constitutionalism based on fundamental laws that establish a clear separation of powers. Such fundamental laws provide legislative elites with the constitutional 'signals' by which they can alert the otherwise slumbering people about an executive intent on usurpation and tyranny.