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The new paradigm of sustainable development (SD) is examined, focusing on its consequence for European cities & the prospects for knowledge-based development. It is argued that the old model of industrial growth gave undue emphasis to science & technology, & that the paradigm of SD offers a policy framework for democratizing & humanizing science. It is further contended that the potential of the SD model will not be realized unless cities reassert their role as civilizing forces, which can be best accomplished by integrating local & global knowledge at the city & regional level. A model of knowledge-based development is presented & applied to the city of Delft, Netherlands. It is concluded that cities must become more responsible for locally-based knowledge, whether organizational or institutional, & that cities need to establish a knowledge infrastructure roundtable to identify & formulate strategies for strengthening their knowledge cultures. 2 Tables, 11 References. W. Howard