Suchergebnisse

Cancer is one of the most common causes of death worldwide and will be responsible for almost 10 million deaths in 2020. In the same year, about 19 million new cases of cancer were diagnosed worldwide [1]. The incidence of all cancers increased between 1998 and 2012 in most countries and in all age groups worldwide [2]. However, at least in Europe, the USA and part of Asia, this trend was in line with demographic changes and population ageing [3,4]. Cancer risk increases with age, and more than 60% of cancers are diagnosed in people aged 65 or older [5]. However, recent studies suggest a sharp increase in the incidence of cancer in adults under 50 years of age [6-15]. In young people diagnosed with cancer, the disease is often more advanced at the time of diagnosis than in older people, partly due to delayed diagnosis [16].

The authors analyse the problem of low persistence in patients with rheumatoid arthritis and discuss the rationale and potential benefits of patient support programs.

Background: Suicide is one of the most important causes of deaths in the United Kingdom, and the numbers are currently increasing. Aim: There are numerous identified determinants of suicidality, and physical multimorbidity is potentially important but is currently understudied. Thus, this study aims to investigate the association of physical multimorbidity with suicidality. Methods: Cross-sectional data from the Adult Psychiatric Morbidity Survey 2007, which was conducted in England between October 2006 and December 2007 by the National Center for Social Research and Leicester University were analyzed. Respondents were asked about 20 physical health conditions, and suicidal ideation and suicide attempts were assessed. Results: Out of 7,403 individuals aged 16 years or over, the prevalence of physical multimorbidity, suicidal ideation, and suicide attempts were 35.1%, 4.3%, and 0.7%, respectively. After adjustment for potential confounders, compared to no physical conditions, 1, 2, 3, and ⩾4 conditions were associated with significant 1.79 (95% CI [1.25, 2.57]), 2.39 (95% CI [1.63, 3.51]), 2.88 (95% CI [1.83, 4.55]), and 6.29 (95% CI [4.12, 9.61]) times higher odds for suicidal ideation. Mediation analysis showed that cognitive problems (mediated percentage 39.2%) and disability (37.5%) explained the largest proportion between multimorbidity and suicidal ideation. Pain (38.0%) and cognitive problems (30.7%) explained the largest proportion between multimorbidity and suicide attempts. Conclusion: In this large sample of UK adults, physical multimorbidity was associated with significantly higher odds for suicidal ideation and suicide attempts. Moreover, several potential mediators were identified, and these may serve as future targets for interventions that aim to prevent suicidality among people with physical multimorbidity.