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Further to the publication by the London School of Economics and Political Science of the report Ending the Drug Wars, this editorial focuses on the mental health impact of the 'war on drugs' and on the need to end such policies in favour of evidence-based interventions to manage drug dependence as a health condition.

ZusammenfassungWährend einer Pandemielage sind Patienten mit Verdacht auf COVID-19 auch im Rahmen von Rettungsdienstalarmierungen zu versorgen. Um ein adäquates Vorgehen zu etablieren, ist die Entscheidungshilfe zur Patientenzuweisung bei Verdacht auf COVID-19 für die Rettungsdienstmitarbeiter sowie für die Notärzte im bayerischen Rettungsdienst erstellt worden. Die Entscheidungshilfe schließt die aktuellen Leitlinien und Empfehlungen zum Thema COVID-19 ein. Für die Darstellung der Entscheidungshilfe wurde ein Flussdiagramm in DIN-A4-Format gewählt, welches nach dem im Rettungsdienst etablierten ABCDE-Schema (A-Airway, B-Breathing, C-Circulation, D-Disability, E-Environment/Exposure)aufgebaut ist. Das Flussdiagramm ermöglicht eine Kategorisierung der Patienten in drei Stufen, welche anhand von (Vital‑)Parametern und Kriterien wie Risikofaktoren und spezifischen Rahmenbedingungen erfolgt. Ziel ist es, Notärzten und Rettungsdienstmitarbeitern eine Orientierungshilfe für die Beurteilung der Patienten sowie daraus entstehende Transportentscheidung mit gegebenenfalls geeigneter Zielklinik an die Hand zu geben.

Background: The rise of multi-morbidity constitutes a serious challenge in health and social care organisation that requires a shift from disease- towards person-centred integrated care. The aim of the current study was to develop a conceptual framework that can aid the development, implementation, description, and evaluation of integrated care programmes for multi-morbidity. Methods: A scoping review and expert discussions were used to identify and structure concepts for integrated care for multi-morbidity. A search of scientific and grey literature was conducted. Discussion: meetings were organised within the SELFIE research project with representatives of five stakeholder groups (5Ps): patients, partners, professionals, payers, and policy makers. Results: In the scientific literature 11,641 publications were identified, 92 were included for data extraction. A draft framework was constructed that was adapted after discussion with SELFIE partners from 8 EU countries and 5P representatives. The core of the framework is the holistic understanding of the person with multi-morbidity in his or her environment. Around the core, concepts were grouped into adapted WHO components of health systems: service delivery, leadership & governance, workforce, financing, technologies & medical products, and information & research. Within each component micro, meso, and macro levels are distinguished. Conclusion: The framework structures relevant concepts in integrated care for multi-morbidity and can be applied by different stakeholders to guide development, implementation, description, and evaluation.

__Background:__ The Palliative Care Consult Service (PCCS) programme was among the first initiations in Hungary to provide palliative care for patients admitted to hospital. The PCCS team provides palliative care for mainly cancer patients and their family members and manages the patient pathway after being discharged from the hospital. The service started in 2014 with 300-400 patient visits per year. The aim of this study is to give a comprehensive overview of the PCCS programme guided by a conceptual framework designed by SELFIE ("Sustainable intEgrated chronic care modeLs for multi-morbidity: delivery, FInancing, and performancE"), a Horizon2020 funded EU project and to identify the facilitators and barriers to its wider implementation. __Methods:__ PCCS has been selected by the SELFIE consortium for in-depth evaluation as one of the Hungarian integrated care models for persons with multi-morbidity. The qualitative analysis of the PCCS programme was based on available documents of the care provider and interviews with different stakeholders related to the programme. __Results:__ The integrated, multidisciplinary and patient-centred approach was well-received among the patients, family members and clinical departments, as verified by the increasing number of requests for consultations. As a result of the patient pathway management across providers (e.g. from inpatient care to homecare) a higher level of coordination could be achieved in the continuity of care for seriously-ill patients. The regulatory framework has only partially been established, policies to integrate care across organizations and sectors and adequate financial mechanism to support the enhancement and sustainability of the PCCS are still missing. __Conclusions:__ The service integration of palliative care

Background: The rise of multi-morbidity constitutes a serious challenge in health and social care organisation that requires a shift from disease- towards person-centred integrated care. The aim of the current study was to develop a conceptual framework that can aid the development, implementation, description, and evaluation of integrated care programmes for multi-morbidity. Methods: A scoping review and expert discussions were used to identify and structure concepts for integrated care for multi-morbidity. A search of scientific and grey literature was conducted. Discussion: meetings were organised within the SELFIE research project with representatives of five stakeholder groups (5Ps): patients, partners, professionals, payers, and policy makers. Results: In the scientific literature 11,641 publications were identified, 92 were included for data extraction. A draft framework was constructed that was adapted after discussion with SELFIE partners from 8 EU countries and 5P representatives. The core of the framework is the holistic understanding of the person with multi-morbidity in his or her environment. Around the core, concepts were grouped into adapted WHO components of health systems: service delivery, leadership & governance, workforce, financing, technologies & medical products, and information & research. Within each component micro, meso, and macro levels are distinguished. Conclusion: The framework structures relevant concepts in integrated care for multi-morbidity and can be applied by different stakeholders to guide development, implementation, description, and evaluation.

The neutrino mass experiment KATRIN requires a stability of 3 ppm for the retarding potential at − 18.6 kV of the main spectrometer. To monitor the stability, two custom-made ultra-precise high-voltage dividers were developed and built in cooperation with the German national metrology institute Physikalisch-Technische Bundesanstalt (PTB). Until now, regular absolute calibration of the voltage dividers required bringing the equipment to the specialised metrology laboratory. Here we present a new method based on measuring the energy difference of two [superscript 83m]Kr conversion electron lines with the KATRIN setup, which was demonstrated during KATRIN's commissioning measurements in July 2017. The measured scale factor M = 1972.449(10) of the high-voltage divider K35 is in agreement with the last PTB calibration 4 years ago. This result demonstrates the utility of the calibration method, as well as the long-term stability of the voltage divider. ; United States. Department of Energy (Grant DEFG02- 97ER41020) ; United States. Department of Energy (Grant DE-FG02-94ER40818) ; United States. Department of Energy (Grant DE-SC0004036) ; United States. Department of Energy (Grant DEFG02-97ER 41033) ; United States. Department of Energy (Grant DE-FG02-97ER41041) ; United States. Department of Energy (Grant DE-AC02-05CH11231) ; United States. Department of Energy (Grant DE-SC00 11091)

A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1.5°, b=0° and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S. RESULTS: No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given. ; The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the French Ministry for Research, the Centre National de la Recherche Scientifique-Institut National de Physique Nucléaire et de Physique des Particules and the Astroparticle Interdisciplinary Programme of the Centre National de la Recherche Scientifique, the United Kingdom Science and Technology Facilities Council (STFC), the Institute of Particle and Nuclear Physics of the Charles University, the Czech Science Foundation, the Polish Ministry of Science and Higher Education, the South African Department of Science and Technology and National Research Foundation, and the University of Namibia. We appreciate the excellent work of the technical support staff in Berlin, Durham, Hamburg, Heidelberg, Palaiseau, Paris, Saclay, and Namibia in the construction and operation of the equipment. R. C. G. Chaves Funded by European Union Seventh Framework Programme Marie Curie, Grant Agreement No. PIEF-GA-2012-332350. ; Peer-reviewed ; Publisher Version