Suchergebnisse

C.L.-O. is supported by grants from European Union (DeAge, ERC-Advanced Grant), Ministerio de Economía y Competitividad SAF2014-52413-R, Instituto de Salud Carlos III (RTICC), CIBERONC, Plan Feder, and EDP Foundation.

This work was supported by grants from Ministerio de Ciencia e Innovación-Spain, Fundación M. Botín, the European Union FP7-MicroEnviMet (to C.L.-O.)and the Intramural Research Programs of the National Human Genome Research Institute, National Institutes of Health, USA (to Y.S.)

This work has been supported by grants from Ministerio de Ciencia e Innovación-Spain, Fundación M. Botín, and European Union (FP7 MicroEnviMet). The Instituto Universitario de Oncología is supported by Obra Social Cajastur and Acción Transversal del Cáncer-RTICC.

This work was supported by grants from European Union (ERCAdvanced Grant, DeAge), Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (CIBERONC), Progeria Research Foundation, and EDP Foundation. We also acknowledge the generous support by J.I. Cabrera. The Instituto Universitario de Oncología is supported by Fundación Bancaria Caja de Ahorros de Asturias

This work was supported by the agency for the Innovation by Science and Technology in Flanders,the Research Council of Ghent University, the Research Foundation Flanders, and the Interuniversity Attraction Poles Program of the Belgian Science Policy (IAP-VI-18). Work at the laboratory of C.L.-O. was supported by grants from the Ministry of Education and Science of Spain,the M. Botín Foundation,the Lilly Foundation,and the European Union.Work at the laboratory of P.M.was supported by grants fromthe Dormeur Foundation. We thank Amin Bredan for editing the manuscript, British Biotech for providing BB-94, Dr. K. Devreese for coagulation tests, Dr. C. Gue´rin for suggestions concerning the confocal studies, Dr.W. Waelput for help with the histopathology, and Sophie Steel and for excellent technical assistance. ; Vandenbroucke, R.E., Dejonckheere, E., Van Lint, P., Demeestere, D., Van Wonterghem, E., Vanlaere, I., Puimège, L., Van Hauwermeiren, F., De Rycke, R., Mc Guire, C., Campestre, C., López-Otin, C., Matthys, P., Leclercq, G., Libert, C.

This study was supported by the Ministerio de Economía y Competitividad, Grant n. SAF2015-67633-R ,and PI16/00420 which are part of Plan Nacional de I+D+I and are co-financed by the European Regional Development Fund (FEDER-"Una manera de hacer Europa") and the CERCA program from Generalitat Catalunya. European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement n. 306240; Generalitat de Catalunya Suport Grups de Recerca AGAUR 2017-SGR1009, and Departament de Salut (SLT002-16-00350), Instituto de Salud Carlos III (ISCIII) International Cancer Genome Consortium for Chronic Lymphocytic Leukemia (ICGC-CLL Genome Project), and project PM15/00007, which is part of Plan Nacional de I+D+I and are co-financed by FEDER. NG is a recipient of a predoctoral fellowship from Agaur and EC is an Academia Researcher of the "Institució Catalana de Recerca i Estudis Avançats" (ICREA) of the Generalitat de Catalunya. ; Giménez, N., Martínez-Trillos, A., Montraveta, A., Lopez-Guerra, M., Rosich, L., Nadeu, F., Valero, J.G., Aymerich, M., Magnano, L., Rozman, M., Matutes, E., Delgado, J., Baumann, T., Gine, E., González, M., Alcoceba, M., Terol, M.J., Navarro, B., Colado, E., Payer, A.R., Puente, X.S., López-Otín, C., Lopez-Guillermo, A., Campo, E., Colomer, D., Villamor, N.

El pdf del artículo es la versión post-print.-- This is an open access article. ; The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), Calcitriol) is a major regulator of gene expression in higher organisms. Protein abundance is an endpoint of gene expression that results from the balance between induction and degradation and is essential for adequate cell function. Proteins are degraded by proteases whose activity is in turn controlled by a number of endogenous protease inhibitors. 1,25(OH)(2)D(3) regulates several proteases and protease inhibitors in different cell types, putatively contributing to its regulatory effects of cell physiology. We have recently shown that 1,25(OH)(2)D(3) strongly induces the expression of cystatin D, an inhibitor of several cysteine proteases of the cathepsin family. Cystatin D induction may contribute to the antitumor effect of 1,25(OH)(2)D(3) against colon cancer by mechanisms that are both dependent and independent of cathepsin inhibition. Transcriptomic studies suggest that 1,25(OH)(2)D(3) also modulates the function of the ubiquitin-proteasome system. Thus, proteases and protease inhibitors are candidates to mediate to a certain extent the complex action of 1,25(OH)(2)D(3) in cancer cells. ; The work in authors' laboratories is supported by Grants from the Ministerio de Ciencia e Innovación of Spain (SAF2007-60341, SAF2006-00476, ISCIII-RETIC RD06/0020/0009), Comunidad de Madrid (S-GEN-0266/2006) and the European Union (MRTN-CT-2005-019496, NucSys and Micoenvimet, FP7). The Instituto Universitario de Oncología is supported by Obra Social Cajastur and Acción Transversal del Cáncer-RTICC. ; Peer Reviewed

This work was supported by the National Institute of Health grant 2R24OD011198-04A1 (W.C.W., PI); National Institute of Environmental Health Sciences [ES016893 (J.W. Sr, PI)]; Army Research Office [W911NF-09-1-0296 (J.W. Sr, PI)]; Swiss National Science Foundation grant PP00P3_170664 (R.M.W.); Ministerio of Economia and Competitividad (Spain); and European Union (ERC-Advanced Grant DeAge) (C.L.-O., PI); the Campbell Foundation; the Ocean Foundation; Ocean Alliance; and the many individual and anonymous Wise Laboratory donors. ; Warren, W.C., Kuderna, L., Alexander, A., Catchen, J., Pérez-Silva, J.G., López-Otín, C., Quesada, V., Minx, P., Tomlinson, C., Montague, M.J., Farias, F.H.G., Walter, R.B., Marques-Bonet, T., Glenn, T., Kieran, T.J., Wise, S.S., Wise, J.P., Waterhouse, R.M., Wise, John Pierce

This work was supported by grants from Ministerio de Educación y Ciencia-Spain, Fundación La Caixa, Fundación M. Botín, and the European Union (FP6 CancerDegradome and FP7 Microenvimet). The Instituto Universitario de Oncología is supported by Obra Social Cajastur-Asturias.

Our study is supported by grants from Ministerio de Ciencia e Innovació n-Spain, Fundación 'M Botín', PCTI-FICYT Asturias and European Union (FP7 MicroEnviMet). The Instituto Universitario de Oncología is supported by Obra Social Cajastur and Acción Transversal del Cáncer-RTICC

G. Kroemer is supported by the Ligue Nationale contre le Cancer (Equipes labelisée), Agence Nationale pour la Recherche, the European Commission (Active p53, Apo-Sys, ChemoRes, and ApopTrain), Fondation pour la Recherche Médicale, Institut National du Cancer, and Cancéropôle Ile-de-France. N. Tavernarakis is supported by grants from the European Union Marie Curie actions and the European Research Council, and T. Eisenberg and F. Madeo are grateful to the European Commission for the grant Apo-Sys. M.V. Bennetzen is supported by the Danish Ministry of Science, Technology, and Innovation (the EliteResearch initiative). C. López-Otín is supported by grants from Ministerio de Ciencia e Innovación–Sp ; Morselli, E., Mariño, G., Bennetzen, M.V., Eisenberg, T., Megalou, E., Schroeder, S., Cabrera, S., Bénit, P., Rustin, P., Criollo, A., Kepp, O., Galluzzi, L., Shen, S., Malik, S.A., Maiuri, M.C., Horio, Y., López-Otín, C., Andersen, J.S., Tavernarakis, N., Madeo, F., Kroemer, G.

This work was supported by grants from Ministerio de Ciencia e Innovación-Spain, Fundación M. Botín, European Union (FP7 MicroEnviMet), Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII

This work was supported by grants from Ministerio de Ciencia e Innovación-Spain, Fundación M. Botín and European Union (FP7-MicroEnviMet); The Instituto Universitario de Oncología is supported by Obra Social Cajastur

Funding: European Union (CancerDegradome-FP6 and FP7); Ministerio de Ciencia e Innovación-Spain; Fundació M Botín; Fundación Lilly; Obra Social Cajastur (to the Instituto Universitario de Oncología). Funding for open access charge: Ministerio de Ciencia e Innovación-Spain.

National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: DK-101633; European Union (ERC Advanced Grant, DeAge); Ministerio de Economia y Competitividad-Spain and Instituto de Salud Carlos III (Feder, Ciberonc), Spain; Fundacion Bancaria Caja de Ahorros de Asturias