Global Justice and the Motivation to Give
In: Fudan Journal of the humanities & social sciences, Band 15, Heft 2, S. 207-226
ISSN: 2198-2600
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In: Fudan Journal of the humanities & social sciences, Band 15, Heft 2, S. 207-226
ISSN: 2198-2600
published_or_final_version ; abstract ; Business ; Doctoral ; Doctor of Philosophy
BASE
In: All azimuth: a journal of foreign policy and peace
In: Substance use & misuse: an international interdisciplinary forum, Band 55, Heft 14, S. 2291-2304
ISSN: 1532-2491
In: Environmental science and pollution research: ESPR, Band 25, Heft 15, S. 15044-15056
ISSN: 1614-7499
In: APSUSC-D-22-01976
SSRN
In: JALCOM-D-22-02276
SSRN
In: Environmental science and pollution research: ESPR, Band 30, Heft 8, S. 21072-21080
ISSN: 1614-7499
AbstractAutoimmune thyroiditis (AIT) is increasingly common, and serological markers include thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). To determine if selected metals influence thyroiditis antibody positivity, this cross-sectional study investigated associations between metals and thyroiditis antibody status. Healthy individuals (n = 1104) completed a questionnaire and underwent checkups of anthropometric parameters, thyroid function status, and levels of seven metals in blood (magnesium, iron, calcium, copper, zinc, manganese, and lead). Associated profiles of glyco- and lipid metabolism were also established. Logistic regression and restricted cubic spline (RCS) regression analysis were applied to adjudge associations between metals and TPOAb and TgAb status. It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower serum concentrations of magnesium and iron. When serum magnesium levels were analyzed in quartiles, the odds ratios of quartile 4 were 0.329–fold (95% confidence interval (CI): 0.167–0647) and 0.259-fold (95% CI 0.177–0.574) that of quartile 1 regarding TPOAb and TgAb positivity (P = 0.004, 0.003). After adjustment, the RCS analysis detected nonlinear associations between iron and TPOAb and TgAb positivity (P < 0.01, both). In stratified analyses, these associations regarding magnesium and iron remained for women of reproductive age, but not for postmenopausal women and men. We conclude that lower serum levels of magnesium and iron are associated with incremental positivity of thyroiditis antibodies and may be among the most important metals contributing to AIT in women of reproductive age.