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PurposeThe purpose of this paper is to focus on a potential tradeoff between security and usability in people's use of online passwords – in general, complex passwords are secure and desirable but difficult to use (i.e. difficult to memorize) whereas simple passwords are easy to use, but are insecure and undesirable. Construal level theory (CLT) explains how high vs low construal level causes people to focus on "desirability" vs "feasibility" of an action, which in the research context can translate into the "security" vs "usability" of using passwords.Design/methodology/approachThe authors conducted a series of three laboratory experiments manipulating people's construal level and investigating its impact on password use.FindingsThe authors found that people who were induced to think at a high construal level created or showed intention to choose stronger passwords relative to people who were induced to think at a low construal level. Furthermore, this effect was also significantly different from the control group who did not receive any experimental treatment. In addition, the authors found that perspective taking targeted at the desirability of creating a strong password further strengthened the effect of a high construal level on intended password choice.Originality/valueThis research makes several contributions to existing literature on password security. First, this research offers CLT as a theoretical lens to explain an individual's thinking and behavior concerning online password use. Second, this research offers empirical evidence that a high construal level improves users' password use, a desirable feature for improved security. Third, this research contributes to the literature on how to apply nudging to influence human behavior toward more desirable, stronger, password use. Finally, our research identifies PT as a factor enhancing the positive effect of a high construal level on online users' password use.

Purpose– The purpose of this paper is to suggest that translating a design theory (DT) into practice (e.g. creating an instance design artifact (IDA)) is hardly straight-forward and requires substantial creativity. Specifically the authors suggest that adopting a DT embodies a creativity passdown effect in which the creative thinking of a team of design theorist(s) inherent in DT invokes a creative mind of a team of artifact instance designer(s) in creating an IDA. In this study, the authors empirically investigate the creativity passdown effect through an action case in which a DT (DT nexus) was applied in creating an IDA (multi-outsourcing decision-making tool).Design/methodology/approach– The case methodology applied here is described as an action case. An action case is a hybrid research approach that combines action research and interpretive case approaches. It combines intervention and interpretation in order to achieve both change and understanding. It is a form of soft field experiment with less emphasis on iteration and learning and more on trial and making. The approach is holistic in philosophy, and prediction is not emphasized. The intervention in the case was that of an instance designer team introducing a previously published DT as a basis for creating an IDA.Findings– The experience in the action case suggests that using a DT in creating an IDA may encourage design thinking, and in certain way increase its power and practical relevance by fostering the creative mind of instance designers. Indeed, DTs provide a scientific basis for dealing with an instance problem, and this evokes the creativity mind of instance designers. Without such a scientific basis, it is a lot more challenging for instance artifact designers to deal with instance problems.Research limitations/implications– This study contributes to the literature concerning design science research, as it challenges the notion that adopting scientific design knowledge limits creativity inherent in creating IDA by illustrating creative elements involved in adopting DT as a basis for creating IDAs.Practical implications– This study offers implications to practice, as it provides new insights regarding how DT can be used in instance design activities.Originality/value– A report of this research previously appeared as a conference paper. However, the attached journal version has been completely rewritten to additionally contribute to the literature concerning design science research beyond the conference version. More specifically, in this version, the authors conceptualize adopting a DT to build an IDA as a theoretical basis, and the authors challenge the notion that adopting scientific design knowledge limits creativity inherent in creating IDA by illustrating creative elements involved in executing DT as a basis for creating IDAs.

Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative stress in human dermal fibroblasts (HDFs). Our results showed that the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of CME was increased in a dose-dependent manner. We found that hydrogen peroxide treatment in HDFs increased ROS generation and cell death as compared with the control. However, CME improved the survival of HDFs against hydrogen peroxide-induced oxidative stress via inhibition of intracellular ROS production. CME treatment inhibited hydrogen peroxide-induced apoptotic cell death and apoptotic nuclear condensation in HDFs. In addition, CME prevented hydrogen peroxide-induced SA-β-gal-positive cells suggesting CME could inhibit oxidative stress-induced premature senescence. Therefore, these results suggest that CME might have protective effects against oxidative stress-induced premature senescence via scavenging ROS.

Korea has become the hub of clinical trials in the world. Korea Good Clinical Practice was legislated in 1995, with an amendment in 2001 to adopt ICH-GCP. New Clinical Trial Authorization (CFA) process, which was introduced in 2002 to streamline the regulatory process along with faster study start up, facilitated clinical trials registration in Korea. Following 2002, the number of multinational trials conducted in Korea began to increase rapidly. It was initially centered on late-phase trials, but subsequently moved on to early phase research incorporating translational research and pharmacokinetic (PK) and pharmamlynamic (PD) studies including ethnic difference research. Globally, Seoul National University Hospital Clinical Trials Center (SNUB CTC) is one of the most experienced clinical research facilities. In 2018, 33 phase III studies, 43 phase II studies, and 44 phase I studies were initiated at SNUB CTC oncology team. Oncology phase I clinical trials contributed 42.7% of newly started phase I clinical trials in SNUH CTC in 2018. One of the most important strengths of our oncology team is that SNUH and Seoul National University Bundang Hospital Clinical Trials Center (SNUBH CTC) is working together in one team for all solid tumor types. This collaborative work was very efficient to recruit patients for multi-cohort in early phase trials including basket trial, umbrella trial, and platform trials. One of the main focus of SNUH oncology team is to perform first in human phase I study. We believe target identification and enrichment through translational research is an important process in drug development. SNUH/SNUBH CTC will continue top-notch clinical trials for the global drug development. ; Y

For South Korean scholars, North Korea is a subject of research pregnant with the meaning of survival of the Korean Peninsula. Based on such a unique position, authors in this book raise and address questions such as how long stability will be maintained in the Kim Jong-un regime, who the power elites behind the system are, and if the North Korean economy is still a Communist planned economy.