Li sees through the media's white noise on the issue of same sex marriage to discover that opponents of Proposition 8 often made claims about the past to sway public perception. These arguments were based on claims evoking a historical sense of the institution of marriage, but to a certain extent they were untrue. This book attempts to dispel some of the misperceptions around the concept of marriage in a historical context. Li also shows that homosexual and heterosexual couples are not exactly the same, and marriage is differently understood. She goes above and beyond merely explicating how th.
Terrorism represents one of the most pressing contemporary security threats. As a consequence, governments provide information to the public on threat levels and on how to respond to terror incidents. To effectively reassure the public, and to increase their vigilance, it is essential that the information communicated is accessible, clear, actionable and engaging. This is the first study to explore the impact of information design principles and visualization of information on the communication of security-related information. Two different but complementary strands were devised: Strand 1 – compared whether more visualised information was more effective than text dense information at communicating to the public; Strand 2 – compared whether a motion graphics was more effective than an infographic at communicating to the public. A survey questionnaire and interview were used to identify problems and needs. Several usability tests and iterations were conducted to develop new design solutions. Empirical testing was then conducted for final evaluation and validation, collecting quantitative and qualitative data. Results show significant differences between pre- and post-knowledge of the Terror Threat Levels. Results also show significant differences between text dense information and more visualised information. Results further show no significant difference between communicating information via an infographic or motion graphics in situations where information needs to be assimilated as a crescendo (i.e. levels of severity) or as a series of steps to be followed (action in an emergency). This study provides important guidelines on how to effectively communicate security information to the public, with practical implications for security agencies.
Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the repertoire of somatic genetic alterations in PALB2-associated breast cancers (BCs), and whether PALB2-associated BCs display biallelic inactivation of PALB2 and/or genomic features of HR-deficiency (HRD). Twenty-four breast cancer patients with pathogenic PALB2 germline mutations were analyzed by whole-exome sequencing (WES, n = 16) or targeted capture massively parallel sequencing (410 cancer genes, n = 8). Somatic genetic alterations, loss of heterozygosity (LOH) of the PALB2 wild-type allele, largescale state transitions (LSTs) and mutational signatures were defined. PALB2-associated BCs were found to be heterogeneous at the genetic level, with PIK3CA (29%), PALB2 (21%), TP53 (21%), and NOTCH3 (17%) being the genes most frequently affected by somatic mutations. Bi-allelic PALB2 inactivation was found in 16 of the 24 cases (67%), either through LOH (n = 11) or second somatic mutations (n = 5) of the wild-type allele. High LST scores were found in all 12 PALB2-associated BCs with bi-allelic PALB2 inactivation sequenced by WES, of which eight displayed the HRD-related mutational signature 3. In addition, bi-allelic inactivation of PALB2 was significantly associated with high LST scores. Our findings suggest that the identification of bi-allelic PALB2 inactivation in PALB2- associated BCs is required for the personalization of HR-directed therapies, such as platinum salts and/or PARP inhibitors, as the vast majority of PALB2-associated BCs without PALB2 bi-allelic inactivation lack genomic features of HRD. ; . The authors thank Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (which has received funding from the NHMRC, the National Breast Cancer Foundation, Cancer Australia, and the National Institute of Health (USA)) for their contributions to this resource, and the many families who contribute to kConFab. Research reported in this paper was supported in part by the Breast Cancer Research Foundation and the Sarah Jenkins Fund, a Cancer Center Support Grant of the National Institutes of Health/National Cancer Institute (grant No. P30CA008748; MSK), a grant of the Ministry of Health of the Czech Republic (NV15-29959A), Charles University projects PROGRES Q28/LF1 and SVV2019/260367, an HIR Grant UM.C/HlR/ MOHE/06 from the Ministry of Higher Education, Malaysia, and the National Health and Medical Research Council, Australia (NHMRC, Project Grant APP1029974). kConFab is supported by a grant from the National Breast Cancer Foundation, and previously by the NHMRC, the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia, and the Cancer Foundation of Western Australia. W.D.F. was funded in part by Susan G Komen. A.L. was supported by the China Scholarship Council. T.N.-D. is an Early Career Fellow of the National Breast Cancer Foundation and M.S. is a NHMRC Senior Research Fellow of the National Health and Medical Research Council. M.T. was funded by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Addenbrooke's Hospital and European Union Seventh Framework Program (2007–2013)/European Research Council (310018). S.P. was supported by the Swiss National Science Foundation (Ambizione grant number: PZ00P3_168165). J.S.R-F. is partly funded by the Breast Cancer Research Foundation and Britta Weigelt by Cycle for Survival.
